DRSC/TRiP Functional Genomics Resources

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Protein Alignment tok and clec-7

DIOPT Version :10

Sequence 1:NP_476879.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_504865.1 Gene:clec-7 / 184314 WormBaseID:WBGene00017364 Length:417 Species:Caenorhabditis elegans


Alignment Length:477 Identity:105/477 - (22%)
Similarity:166/477 - (34%) Gaps:165/477 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   863 LPNKECVWKITVPESYQVALK--------FQSFEVENHDSCVYDYVEVRDGPGQDAPL--IGVFC 917
            |.|.:|:...|.|.::..|.|        ..:.:.||.:..:..:.      |..|.|  ||::|
 Worm    31 LINNKCLKLFTTPANHSAAEKTCRKYGATLVTVKNENDNHAISTFA------GTSASLLWIGLYC 89

  Fly   918 GYKPPPNM---KSSGNS-MYVKFVSD-----------TSVQKAGFSAVFMKEVDECETQNHGCE- 966
            ....|...   .|:|:: :|..|.|.           .|||.| .:..::.|..:..::...|| 
 Worm    90 FGNDPSKCLWDDSTGSADVYDNFASGFPLVDIGKCVYYSVQGA-LTGKWLTENCDLSSKAFMCEL 153

  Fly   967 -----HECINTLGGYECSCRIGFELHSD------KKHCEDACGGVI----------------EYP 1004
                 ..||....||   |   ::.:::      :..||..||.:.                .||
 Worm   154 PTTFSDSCIYNYNGY---C---YDYYAEASFVVAQNTCEQFCGDLATIHTANENRYILTVAQHYP 212

  Fly  1005 NGTI-----TSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSK 1064
            :.||     |.|: ..:|..:....||            :.:.||.|.  :..||          
 Worm   213 SSTIVRIGATWPA-SNVYQWVDGLPWE------------YKNIDLTGP--RGGDC---------- 252

  Fly  1065 LGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHEC 1129
                       ...|:.||:..:                    |..:|         ...|..| 
 Worm   253 -----------MVMSTRPPSPVA--------------------AGYWF---------GASCTDE- 276

  Fly  1130 RNTIGSYICMCHNGYS------------MHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNA 1182
            ||    :||....|..            :.:|...|.    ...:.|| |.:.|||:|.:|..||
 Worm   277 RN----FICKRPAGLQCVGTPPSVTISPIQDNPSFCN----STNLLAP-GVVTSPNFPRNYNNNA 332

  Fly  1183 DCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQ 1247
            .|.:...|...:.|.|.|..|.:.     |.|.|.||||||.||.|:|.:.|..:||.:.|:||.
 Worm   333 FCTYQLSTLGSYNILLRFAPFSLG-----TSDYVIVYDGESASSPVIGNYSGTLVPFSLISSSNN 392

  Fly  1248 MYMVLKTDKNKQKNGFTASHST 1269
            :.:|...:...|  ||:|.:::
 Worm   393 LLVVFNGNTGGQ--GFSARYTS 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_476879.1 ZnMc_BMP1_TLD 520..721 CDD:239808
CUB 723..836 CDD:412131
CUB 840..951 CDD:395345 25/112 (22%)
FXa_inhibition 958..993 CDD:464251 7/46 (15%)
CUB 997..1111 CDD:395345 20/134 (15%)
FXa_inhibition 1118..1153 CDD:464251 8/46 (17%)
CUB 1158..1267 CDD:395345 40/108 (37%)
CUB 1271..1390 CDD:238001
clec-7NP_504865.1 CLECT 25..152 CDD:214480 26/127 (20%)
CLECT 165..282 CDD:214480 31/192 (16%)
CUB 308..412 CDD:238001 41/115 (36%)
Blue background indicates that the domain is not in the aligned region.

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