DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-14

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_502533.2	Gene:	nas-14 / 184247	WormBaseID:	WBGene00003533	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	82/243 - (33%)
Similarity:	128/243 - (52%)	Gaps:	20/243 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 VPEM---DLLKA---ETSKDEEPL----RHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALF 550
            |||:   |:||.   :...||:.:    .|.....|| ..:::|..|.:||.::...:...:...
Worm    83 VPEIEKSDILKRLRDDPLLDEDEIFRKPFHSALNLVT-YPDKLWPEGQVPYMLEEGMTNDQRTAI 146

  Fly   551 KLAMRHWENSTCIKFVER-DPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIG-RNCDKFGIVV 613
            ..|...::..||::||.: |.:....|:...| :.||.|:||:.| |.|.:|:. ..|...||:.
Worm   147 AQAFDEYKTKTCVRFVPKTDDDFDYIYVKRNV-AFGCSSYVGRAG-GNQTVSLEVDKCFSKGIIA 209

  Fly   614 HELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTF 678
            |||.|.:||:|||:|.||:..|.|..:||..|...||.......:|||||.|||:|:|||.:..|
Worm   210 HELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKIIDSLGMPYDYESVMHYHKLAF 274

  Fly   679 SKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRT 726
            |:.. ..||:|.:    ...::|||.:||:.|..:.|.||:|.:..:|
Worm   275 SRNG-KPTIIPKD----NEADVGQRYKLSEMDSKKVNKLYQCGEYSKT 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	71/202 (35%)
		Astacin	527..721	CDD:279708	69/195 (35%)
		CUB	723..836	CDD:294042	1/4 (25%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-14	NP_502533.2	Astacin	123..313	CDD:279708	70/196 (36%)
		ZnMc_astacin_like	128..309	CDD:239807	66/187 (35%)
		ShKT	380..414	CDD:214586
		ShK	468..503	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3510
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.760