DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-8

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_501114.2	Gene:	nas-8 / 183207	WormBaseID:	WBGene00003527	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	248	Identity:	73/248 - (29%)
Similarity:	119/248 - (47%)	Gaps:	19/248 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 FNQSQQAQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKE------------RIWDYGVIPYE 537
            |...::..:..||...:|..:..|..: :|.:.|..:..|..            |.|..|.|||.
Worm    66 FKNGEKLGEDHVPAGSILWKQVYKKGD-IRGKAAWKLDPKNSESLRRNGVITGTRKWPNGRIPYV 129

  Fly   538 IDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISI 602
            |...::...:|:...:.:.:.:.||::||.| ..:..:|: :..:..||.|.||:.| |.|.:|:
Worm   130 ISNQYNDRERAVLARSFQAYHDKTCVRFVPR-TAVDNDYL-YIGKIDGCYSDVGRAG-GRQELSL 191

  Fly   603 GRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDY 667
            ...|.::...:|||.|.|||:|||.|.||::|:.|..:||.:.....|..:...|....|..|||
Worm   192 DNGCLQYDTAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQFGKVDLAESSYYGQLYDY 256

  Fly   668 DSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKC 720
            .|||||....|||..: :|:  :..:......||..:..|..||.:.||:|:|
Worm   257 YSIMHYDSLAFSKNGF-ETM--VAKQSEMTAVIGAAIDFSPIDILKMNLMYQC 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	66/213 (31%)
		Astacin	527..721	CDD:279708	65/194 (34%)
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-8	NP_501114.2	Astacin	119..308	CDD:279708	65/194 (34%)
		ZnMc_astacin_like	123..304	CDD:239807	61/186 (33%)
		ShK	337..372	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810