DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-4

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001254938.1	Gene:	nas-4 / 182259	WormBaseID:	WBGene00003523	Length:	365	Species:	Caenorhabditis elegans

Alignment Length:	292	Identity:	98/292 - (33%)
Similarity:	143/292 - (48%)	Gaps:	34/292 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 EMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTC 562
            |.|:|.....|..|. .:::.|....:..|.|....|||.:...:....:::...||..:...||
Worm    74 EGDILLESPKKFVEE-NNKLGRNAIKQIYRRWPNNEIPYTLSSQYGSYARSVIANAMNEYHTKTC 137

  Fly   563 IKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHT 627
            :|||.|||..|.:|: :.....||.|.|||.| |.|.:|:...|.:.|.:||||.|.|||:||.:
Worm   138 VKFVARDPSKHHDYL-WIHPDEGCYSLVGKTG-GKQPVSLDSGCIQVGTIVHELMHAVGFFHEQS 200

  Fly   628 RPDREKHVVIEHNNIMKGQD-----YNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTI 687
            |.||:.::.:...|:|.|.|     ||.|::|     .|...|||.|||||....|| |:...|:
Worm   201 RQDRDSYIDVVWQNVMNGADDQFEKYNLNVIS-----HLDEPYDYASIMHYGPYAFS-GSGKKTL 259

  Fly   688 LPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQ-------ESSGIFASPSHYTAG-- 743
            :| :..|.:|  :|||::.|..|:.:.|.||.||.......       .|:.|...|....||
Worm   260 VP-KKSGSER--MGQRVKFSDIDVRKINKLYNCPGVSGNNNNNNNNQINSNSIVNHPQSRYAGLP 321

  Fly   744 -ALSNETEHCE---WRI----TATYGERVELK 767
             :.||:||.||   ||.    ..:|.:|.|::
Worm   322 LSTSNQTEPCEDLTWRCRFWSLFSYCQRREVR 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	74/205 (36%)
		Astacin	527..721	CDD:279708	74/198 (37%)
		CUB	723..836	CDD:294042	16/62 (26%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-4	NP_001254938.1	Astacin	102..290	CDD:279708	74/198 (37%)
nas-4	NP_001254938.1	ZnMc_astacin_like	106..287	CDD:239807	70/191 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910