DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-10

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001257126.1	Gene:	nas-10 / 181287	WormBaseID:	WBGene00003529	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	236	Identity:	68/236 - (28%)
Similarity:	106/236 - (44%)	Gaps:	33/236 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 IPYEIDGNFSGIHKALFKLAMRHWENSTCI--KFVERDPE-IHPNY-IVFTVRSCGCCSFVGK-R 593
            |||..|.:...:.:...:.|:...|..|||  |:....|: .|.|| .|.:...|| .|::|: .
Worm   311 IPYTFDSSLDNLDQNDVRGAISEIEQKTCIRFKYFASPPKGNHINYQKVNSPSFCG-LSYIGRVE 374

  Fly   594 GNGPQAISI----GRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLS 654
            ...|..:|.    ||     ||.|||..|.:|..|:|.|.||:||:.::.:|| ..|.|:..:::
Worm   375 PANPVYLSFQCGNGR-----GIAVHETMHALGVNHQHLRMDRDKHIKVDWSNI-NPQQYDAFVVA 433

  Fly   655 PDEV-DSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLY 718
            ..:: .:.|:.|.|||||||...|.:......|::|:..:......:|||.::|..|:...|.:|
Worm   434 DSKLYTTYGVKYAYDSIMHYNAYTGAVNIAKPTMIPLVNQQANIGLLGQRAKMSNADVEILNKMY 498

  Fly   719 KCPKCGRTFQESSGIFASPSHYTAGA-----LSNETEHCEW 754
             |...|          ....:...||     |.|...|..|
Worm   499 -CKSAG----------CDDKNVYCGAWALQDLCNNPNHNVW 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	60/196 (31%)
		Astacin	527..721	CDD:279708	60/196 (31%)
		CUB	723..836	CDD:294042	7/37 (19%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-10	NP_001257126.1	Astacin	303..501	CDD:396122	61/197 (31%)
nas-10	NP_001257126.1	ShK	503..540	CDD:396228	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910