DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and nas-37

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001024413.1	Gene:	nas-37 / 181208	WormBaseID:	WBGene00003553	Length:	765	Species:	Caenorhabditis elegans

Alignment Length:	849	Identity:	185/849 - (21%)
Similarity:	273/849 - (32%)	Gaps:	258/849 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 SVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWEN 559
            ::|:.:.|.:|::..      |..|.........|....|.||..|. ....:.|.:.|:||.|.
Worm    96 TLPQAESLLSESNSP------RSRRQAHPDPRNFWPNLTISYEFYGG-EETWRQLIRSAIRHVEQ 153

  Fly   560 STCIKFVE----RDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVV 620
            :.|.||.|    ||.       :...|..||.|.||:.| |.|.:|||..||..|||.||..|.:
Worm   154 NVCFKFKENGGDRDG-------LRYYRGNGCWSNVGRVG-GRQLVSIGYGCDSLGIVSHETLHAL 210

  Fly   621 GFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLD 685
            |.|||.:|.||:..:.|..:.|.:|.:.||...:....|:||..||..|:|||...:|:.....|
Worm   211 GLWHEQSRDDRDNFISIVADKITRGTEGNFAKRTAANSDNLGQPYDLGSVMHYGAKSFAYDWSSD 275

  Fly   686 TILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETE 750
            ||...:.  |.:..||||..||..|....|..|....|.|:....:..:..|         |...
Worm   276 TIKTRDW--RYQNTIGQRDGLSFKDAKMINTRYCSNVCQRSLPCLNEGYTDP---------NNCG 329

  Fly   751 HCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSR 815
            .|  |..:.||                                    |.:|..|:
Worm   330 RC--RCPSGYG------------------------------------GTYCETVE---------- 346

  Fly   816 MLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQV 880
                |.:                 |||.|:...:..::||....    |:..|||:|..|.. .|
Worm   347 ----YTS-----------------CGGSLTASSSYKKIESGIVQ----PDANCVWRIRNPGG-NV 385

  Fly   881 ALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYV--KFVSDTSVQ 943
            .:.|.....:..|.| ..||||:....:.:....:.|..  |..::|.|:.:.:  :...:|:|.
Worm   386 EVMFDQVNFQCADPC-QSYVEVKYLSQKTSTGARLCCSL--PSVIRSEGDDVIIILRGTPNTAVG 447

  Fly   944 KAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTI 1008
            ..||:..:.                                           |.||.      .|
Worm   448 WRGFTLKYR-------------------------------------------AIGGT------PI 463

  Fly  1009 TSPSFPEMYPLLKECIW--------EIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKL 1065
            |..:....|.......|        .|..||.::........|     .|.::..|.|..:|..
Worm   464 TPATVRPTYATTTRPYWTRTASGWIHIKNPPLYKPDGQIYTSD-----EQSAETKYSSEELYDP- 522

  Fly  1066 GENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDE------------- 1117
                    .||    :.|:::|.|.||.|.  ||.|.||........:.:.:
Worm   523 --------STF----LSPSSSSASPALLLP--SDASPQRPSAQEHDLSQLSQNALTRPTPTTTVA 573

  Fly  1118 --------------CAVNNGGCQHECRNTI---GSYICMCHNGYSMHENGHDC---KEGE-CKYE 1161
                          |:...|||..:.|...   |:.:|...|......|.|.|   |:|. |...
Worm   574 PDTASWSAWGEWSACSQPCGGCGTKTRVRACYGGNQVCPGSNLDRESCNAHACAKPKKGMICNGR 638

  Fly  1162 ISAP--------FGT--IFSPNYPDSYPPNADCVWHFITTPGHRI---KLIF-NEFDVESHQECT 1212
            :..|        ||:  ..:|....|....:.      |.|..||   |.:| ||.:|....|
Worm   639 LLLPCDLLAKLNFGSNNYLNPKLKQSGFARSS------TLPLPRISQRKPVFVNELEVHPPTE-- 695

  Fly  1213 YDNVAVYDGESESSS-------VLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTA 1270
                     ...|||       ...|||..:..:...:....:.|..|.|.....:.:...:...
Worm   696 ---------RFLSSSTRRVKRQTANRFCEKRFIYQCPTALLTIQMEYKPDTQGTNDAYFQQYPEC 751

  Fly  1271 CGGY 1274
            |.||
Worm   752 CSGY 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	71/204 (35%)
		Astacin	527..721	CDD:279708	71/197 (36%)
		CUB	723..836	CDD:294042	12/112 (11%)
		CUB	840..951	CDD:278839	28/112 (25%)
		FXa_inhibition	958..993	CDD:291342	0/34 (0%)
		CUB	997..1111	CDD:278839	27/121 (22%)
		FXa_inhibition	1118..1153	CDD:291342	10/37 (27%)
		CUB	1158..1267	CDD:278839	25/129 (19%)
		CUB	1271..1390	CDD:238001	3/4 (75%)
nas-37	NP_001024413.1	Astacin	122..309	CDD:279708	71/197 (36%)
		ZnMc_astacin_like	126..306	CDD:239807	69/190 (36%)
		CUB	370..455	CDD:214483	22/88 (25%)
		TSP1	579..626	CDD:214559	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910