DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-11

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001024789.1	Gene:	nas-11 / 180938	WormBaseID:	WBGene00003530	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	68/247 - (27%)
Similarity:	106/247 - (42%)	Gaps:	24/247 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 EMDLLKAETSKDEEPLRHRVARAVTAKKERI--------------WD-YGVIPYEIDGNFSGIHK 547
            |:.|..|:|..:::......|........|:              || ...|.|.:|.:...:.|
Worm   296 EIPLPDADTDDEDDDDSTNSASGAAPGSSRLKKSALYFEGNLIKKWDPSSPIRYVLDSSLEDLDK 360

  Fly   548 ALFKLAMRHWENSTCIKFVE-RDPEIHPNYIVFTVRS---CGCCSFVGKRG-NGPQAISIGRNCD 607
            ...:.|:...|.:|||:|.| ..|....:.:.:.|.|   || .|:||:.. ..|..:|.|  ||
Worm   361 NDVRAAIYEIEKNTCIRFKELSSPPTGSHIVYYKVDSPTFCG-LSYVGRADPANPVYLSFG--CD 422

  Fly   608 -KFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIM 671
             ..|:.:||..|.:|..|:|.|.||::.:.|..:||...|...|.::......|.|:.|.|||||
Worm   423 NNKGVAIHETMHALGVAHQHLRNDRDQFITINWSNIDPQQYDAFVVVDSKLYTSYGVKYAYDSIM 487

  Fly   672 HYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKC 723
            ||...|.::...:.|:.|..........:|||.::...||.....:|..|.|
Worm   488 HYNGYTAAQNIAIPTMNPKTNSAVNLKVLGQRQKMGTTDIELLKKMYCQPGC 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	61/221 (28%)
		Astacin	527..721	CDD:279708	61/214 (29%)
		CUB	723..836	CDD:294042	1/1 (100%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
nas-11	NP_001024789.1	Astacin	339..537	CDD:279708	60/200 (30%)
		ZnMc_astacin_like	346..534	CDD:239807	57/190 (30%)
		ShK	538..575	CDD:279838	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910