DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-38

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001359993.1	Gene:	nas-38 / 180407	WormBaseID:	WBGene00003554	Length:	727	Species:	Caenorhabditis elegans

Alignment Length:	755	Identity:	176/755 - (23%)
Similarity:	259/755 - (34%)	Gaps:	220/755 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 VNHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPL------RHRVARAVTAKKERIWD-YGVIP 535
            |:|.....|.:.:..|..|   ||.:.:....|:..      :.::.|....||   || .|.|.
Worm    73 VHHDELAVNNADEYFQGDV---DLSEQQVKIIEDQFTQGKREKRKIGRNPLYKK---WDTRGPIS 131

  Fly   536 YEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAI 600
            ::...:.....:...:.||..|:..||::|.|..|.:  :.:.| ....||.||||:.| |.|.|
Worm   132 FDYAESIPFQTRQKIRSAMLLWQQHTCLRFEEGGPNV--DRLEF-FDGGGCSSFVGRVG-GTQGI 192

  Fly   601 SIGR-NCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMA 664
            ||.. .||..||:.||:||.:|.:||..|||:|:|:.|.:|||...:..||..:..:..::..:.
Worm   193 SISTPGCDVVGIISHEIGHALGIFHEQARPDQERHIAINYNNIPLSRWNNFQAVGENHAETYNLP 257

  Fly   665 YDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQE 729
            ||..|:|||....|:...|..||..:|..  ::..||||...|..|....|:.|.|
Worm   258 YDTGSVMHYGPYGFASDPYTPTIRTLERV--QQSTIGQRAGPSFLDYQAINMAYGC--------- 311

  Fly   730 SSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKS 794
                               ||.|           .:|..........|||  ......:|
Worm   312 -------------------TESC-----------ADLPCLRNGYTHPNNC--SMCACPEG----- 339

  Fly   795 PLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYP 859
             |.||:|.:|               |.:              :..|||.:.....|..:.|||||
Worm   340 -LSGRYCEQV---------------YPS--------------NAQCGGVIFATKEVKYITSPNYP 374

  Fly   860 LDYLPNKECVWKITVPESYQVALKFQ-SFEVENHDSCVYDYVEVRDGPGQDAPLIGV--FCGYKP 921
            ..:..:.||.|.|..|...:|.::|: .|:....|:|...||||:  ...|..|.|.  .|...|
Worm   375 DKFPIDTECNWIIAAPIEGRVFMEFEGDFDFLCEDTCDKAYVEVK--YHSDKRLTGARYCCSLLP 437

  Fly   922 PPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFEL 986
            .....|..|.|.: .:.......|||.|.|...:.|
Worm   438 KNRFISFKNEMII-IMRGYRSSGAGFKAKFWSNLGE----------------------------- 472

  Fly   987 HSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKH---RISLNFTHFDLEGTA 1048
                             |.| :::|..|...||.:  |.|....|:.   :.:..:|......||
Worm   473 -----------------PEG-VSTPLPPTTAPLPE--ISETTQKPEPTTVQSTTTYTTAIPRRTA 517

  Fly  1049 HQQ----------------SDCGYDSVTVYS--------------KLGENRL----KRIGTFCG- 1078
            .:|                |....:|.||.|              ..||..:    ..|..|..
Worm   518 KKQFFTRKPITIPLTPLTSSSTTTESTTVSSTTQSTTWLPTEPSFATGETEITTASPTITLFPSL 582

  Fly  1079 SSIPPTATSESNALRLEFHSD--KSIQRSGFAAVFFTDID-ECAVNNGGCQHECRNTIGSYICMC 1140
            |:|.|...|.:..|......|  .|:...|..|  :::.. ||:...|||.|..|.
Worm   583 STILPPINSLAGVLPSTQAPDIINSVLECGCGA--WSEWQGECSQQCGGCGHRLRK--------- 636

  Fly  1141 HNGYSMHENGHDCKEGECKYE-------ISAPFGTIFSPN 1173
                      .:||:..|:.|       .:.|.||.|..|
Worm   637 ----------RECKKEACRKEEKRPCNFSACPDGTNFLIN 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	68/202 (34%)
		Astacin	527..721	CDD:279708	66/195 (34%)
		CUB	723..836	CDD:294042	14/112 (13%)
		CUB	840..951	CDD:278839	35/113 (31%)
		FXa_inhibition	958..993	CDD:291342	0/34 (0%)
		CUB	997..1111	CDD:278839	31/153 (20%)
		FXa_inhibition	1118..1153	CDD:291342	6/34 (18%)
		CUB	1158..1267	CDD:278839	7/23 (30%)
		CUB	1271..1390	CDD:238001
nas-38	NP_001359993.1	Astacin	122..313	CDD:366617	69/227 (30%)
		CUB	367..466	CDD:214483	31/101 (31%)
		TSP1	613..658	CDD:214559	12/65 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810