DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and dpy-31

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_001022731.1	Gene:	dpy-31 / 176014	WormBaseID:	WBGene00006592	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	673	Identity:	172/673 - (25%)
Similarity:	254/673 - (37%)	Gaps:	171/673 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 DDEVDFLHSRGVVRRRHRRGPKQRRSNQHLEHEVKLQRLREELSRPVIEAHHHQSHHQKQAQHRQ 450
            |:|.....:.||.:||......|:..:.:::   ||.:|.:|                      :
Worm    26 DEEDPPSSAPGVRKRRMMSEEDQKTVDYYMD---KLNKLADE----------------------K 65

  Fly   451 HHQSHHRKKHRRQQQHHRRRGQSTTQYVNHSPPG-FNQSQ----QAQQQSVPEMDLLKAETSKDE 510
            |.:...|.|:.......|:|    ...:|....| |.|..    ..|.:::.|..|.:.:|
Worm    66 HPEEIERHKNPELVAWDRKR----DSVLNPEEQGKFFQGDIVLYPEQAKALYEQALTEGKT---- 122

  Fly   511 EPLRHRVARAVTAKKERIWDYG-VIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHP 574
                 ||.|.......|.||.. .|.|..||:.:...:.:.:||:.||.|.||:.|...|.....
Worm   123 -----RVKRKFIGSNLRRWDASRPIIYAFDGSHTQREQRIIELALEHWHNITCLNFQRNDQANSG 182

  Fly   575 NYIVFTVRSCGCCSFVGKRGNG-PQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIE 638
            |.||||... ||.|.||:...| .|.:|:...|.:.|::.||:.|.:|||||.:||||:::|.:.
Worm   183 NRIVFTDVD-GCASNVGRHPLGEEQLVSLAPECIRLGVIAHEVAHALGFWHEQSRPDRDQYVTVR 246

  Fly   639 HNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQR 703
            ..||.|.....|....||:||:.|:.|||.|||||....|||...|.||.......:|  .||||
Worm   247 WENIDKDSKGQFLKEDPDDVDNAGVPYDYGSIMHYRSKAFSKFDDLYTISTYVTDYQK--TIGQR 309

  Fly   704 LRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKL 768
            .:||..||...|.:|....|........|.:..|
Worm   310 DQLSFNDIRLMNKIYCSAVCPSKLPCQRGGYTDP------------------------------- 343

  Fly   769 ENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFK 833
                    ..|  |.....||:      .|::|.:|                        ..|:.
Worm   344 --------RRC--DRCRCPDGF------TGQYCEQV------------------------MPGYG 368

  Fly   834 AEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKF-QSFEVE---NHDS 894
            |    .|||::|:..:..|:.||.||.::...:||.|.:..|..:.|..:| ..||:.   .|..
Worm   369 A----TCGGKISLTRSTTRISSPGYPREFKEGQECSWLLVAPPGHIVEFQFIGEFEMYCKIRHSL 429

  Fly   895 CVYDYVEVRDGPGQDAPLIGV-FCGY-KPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDE 957
            |: ||||||:  ..|....|: :|.| .||..::|:...|.|.|.|.....| ||.| ..:.|.|
Worm   430 CM-DYVEVRN--STDFANTGMRYCCYGTPPTRIRSATTDMVVLFRSFYRGGK-GFEA-RARAVPE 489

  Fly   958 CETQN---------------------------HGCEHECINTLGGYECSCRIGFELHSDKKHCED 995
            ....|                           :.|..|.:.|   ..|:.:....:.:.|:..|.
Worm   490 AGNWNSWSPWTACSATCGACGSRMRTRTCPPGNACSGEPVET---QICNTQACTGMCAQKREEEG 551

  Fly   996 ACGGVIEYPNG-------TITSP 1011
            .|||.:....|       |:.:|
Worm   552 QCGGFLSLLRGVRCRQEKTVMAP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	78/202 (39%)
		Astacin	527..721	CDD:279708	78/195 (40%)
		CUB	723..836	CDD:294042	12/112 (11%)
		CUB	840..951	CDD:278839	40/116 (34%)
		FXa_inhibition	958..993	CDD:291342	6/61 (10%)
		CUB	997..1111	CDD:278839	6/22 (27%)
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
dpy-31	NP_001022731.1	Astacin	134..327	CDD:279708	78/195 (40%)
		ZnMc_astacin_like	139..324	CDD:239807	74/187 (40%)
		CUB	383..483	CDD:214483	36/104 (35%)
		TSP1	493..539	CDD:214559	5/48 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910