DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and toh-1

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_497769.3	Gene:	toh-1 / 175491	WormBaseID:	WBGene00006591	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	386	Identity:	112/386 - (29%)
Similarity:	165/386 - (42%)	Gaps:	80/386 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 VPEMDLLKA---------ETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEI---DGNFSGIHKA 548
            :|.::::.:         ||....:..|||  |.|.|.:...|:...||::|   |.||    ::
Worm    31 IPGLEVMASDKYPHFTTIETVSRTKVHRHR--REVIAGQIYDWNSYEIPFQIWGGDYNF----QS 89

  Fly   549 LFKLAMRHWENSTCIKFVE----RDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKF 609
            |.:..:|.||:|||::|.|    ||.   ..|::....|| ...::|:.| |.|.|.||..|.:.
Worm    90 LIRRGIRMWEDSTCLRFKENQQSRDA---IRYVLEKGDSC-FTEYIGRNG-GHQDIIIGSECAEE 149

  Fly   610 GIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKG------------QDYNFNMLSPDEVDSLG 662
            .:|.||.||.:||||.|.||||::|:.|...|:|:.            |.:....:||..|
Worm   150 YVVAHETGHALGFWHTHQRPDRDRHISINWKNVMEEATASFMPFRSMLQAFGIRQVSPRRV---- 210

  Fly   663 MAYDYDSIMHYARNTFSKGTYLDTILPIEMK-----GRKR--------------PEIGQ---RLR 705
             .|||.|:|||.....:......||:|.|:|     |.::              |...|   .|.
Worm   211 -PYDYGSLMHYHAVAHAVKVSDFTIVPKELKYVTTMGTEKMAFLDAKVINDIYCPNACQGRNHLN 274

  Fly   706 LSQGDIAQANLLYKC--------PKCGRTFQESSG--IFASPSHYTAGALSNETEHCEWRITATY 760
            ...|.....|....|        |.|||......|  |.||....|..:.|....||.|||:...
Worm   275 CLAGGYPDPNNCNVCRCPEGLGGPDCGRLQPSPCGGEIHASDQWQTLSSPSGRDVHCYWRISVPE 339

  Fly   761 GERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIG-RFCGKVDKEVIRTESSRMLLTY 820
            |.||..:|.:.....|..|:: |:||:.....:  |.| |.|....||...:||:::.:.|
Worm   340 GSRVRFRLSDGEFPCSYGCQS-YVEIKHKLDVR--LTGFRSCCYRPKEDTVSESNQIFVIY 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	72/249 (29%)
		Astacin	527..721	CDD:279708	70/242 (29%)
		CUB	723..836	CDD:294042	32/101 (32%)
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
toh-1	NP_497769.3	Astacin	71..265	CDD:279708	64/207 (31%)
		ZnMc_astacin_like	73..262	CDD:239807	63/202 (31%)
		CUB	320..410	CDD:214483	25/81 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810