Protein Alignment tok and Mep1a

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_032611.2
• Gene: Mep1a / 17287
• MGIID: 96963
• Length: 760
• Species: Mus musculus
• Alignment Length: 811
• Identity: 181/811 - (22%)
• Similarity: 272/811 - (33%)
• Gaps: 285/811 - (35%)

  Fly   492 QQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRH 556
            :|:.:.|::|.........:.|..|...|:.....| |.. .|||.:..|.....|.....|...
Mouse    51 EQKDIFEINLAAGLNLFQGDILLPRTRNAMRDPSSR-WKL-PIPYILADNLELNAKGAILHAFEM 113

  Fly   557 WENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVG 621
            :...:|:.|...:.|  .:||:|...| ||.|.:|.:..| |.||||..||....:.||:.|.:|
Mouse   114 FRLKSCVDFKPYEGE--SSYIIFQKLS-GCWSMIGDQQVG-QNISIGEGCDFKATIEHEILHALG 174

  Fly   622 FWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDT 686
            |:||.:|.||:.:|.|..:.|:...::|||....:.:..|...|||:|:|||...:|:|...:.|
Mouse   175 FFHEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPT 239

  Fly   687 ILPIEMKGRKRPE----IGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSN 747
            |.      .|.||    |||....|..|:.:.|.:|.|.                      |...
Mouse   240 IT------TKIPEFNTIIGQLPDFSAIDLIRLNRMYNCT----------------------ATHT 276

  Fly   748 ETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCG-KVDKEVIRT 811
            ..:||:                                     |||:.:.|...| :.|.:....
Mouse   277 LLDHCD-------------------------------------FEKTNVCGMIQGTRDDADWAHG 304

  Fly   812 ESS---RMLLTYVNTHRIEGFRGFKAEFDVVCG--GELSVDDAVGRLESPNYPLDYLPNKECVWK 871
            :||   ::..|.|...:..|:..|   |:...|  ||.::      |||               :
Mouse   305 DSSQPEQVDHTLVGQCKGAGYFMF---FNTSLGARGEAAL------LES---------------R 345

  Fly   872 ITVPESYQVALKF---------QSFEVENHDSCVYDYVEVRDGPGQDAPL--IGVFCGYKPPPNM 925
            |..|:..|..|:|         ..|||         :|...|..|:...|  |..|.|
Mouse   346 ILYPKRKQQCLQFFYKMTGSPADRFEV---------WVRRDDNAGKVRQLAKIQTFQG------- 394

  Fly   926 KSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGY--------ECSCRI 982
             .|.::..:..|:....:|  |..||:           |.:.:..|:.||.        |..|..
Mouse   395 -DSDHNWKIAHVTLNEEKK--FRYVFL-----------GTKGDPGNSSGGIYLDDITLTETPCPA 445

  Fly   983 GF-----------------ELHSDKKHCEDACG-GVIEYPNGTITSPS------FPEMYPLLKEC 1023
            |.                 :|.|.:.:..:..| ||..||||.|||.|      | .:|....:.
Mouse   446 GVWTIRNISQILENTVKGDKLVSPRFYNSEGYGVGVTLYPNGRITSNSGFLGLTF-HLYSGDNDA 509

  Fly  1024 I--WEI------------VAPPKHRISLN--FTHFDLEGTAHQQSDCGYD---------SVTVYS 1063
            |  |.:            .|..::|:||.  ||      |:..|:....:         .|.||.
Mouse   510 ILEWPVENRQAIMTILDQEADTRNRMSLTLMFT------TSKNQTSSAINGSVIWDRPSKVGVYD 568

  Fly  1064 K---------------LGENRLKRIGTFCGSS-----------------IPPTATS--------- 1087
            |               :....|||.....|.|                 :|.:|.|
Mouse   569 KDCDCFRSLDWGWGQAISHQLLKRRNFLKGDSLIIFVDFKDLTHLNRTEVPASARSTMPRGLLLQ 633

  Fly  1088 --ESNAL-------------------RLEFHSDKSIQRSG------FAAVFFTDIDECAVNNGGC 1125
              ||.||                   |......:|::.:|      :...|   .|.|..|  .|
Mouse   634 GQESPALGESSRKAMLEESLPSSLGQRHPSRQKRSVENTGPMEDHNWPQYF---RDPCDPN--PC 693

  Fly  1126 QHE--CRNTIGSYICMCHNGYSMHENGHDCK 1154
            |:|  |.|..|...|.|.:|::....|..|:
Mouse   694 QNEGTCVNVKGMASCRCVSGHAFFYAGERCQ 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	66/204 (32%)
		CUB	723..836	CDD:412131	15/116 (13%)
		CUB	840..951	CDD:395345	25/123 (20%)
		FXa_inhibition	958..993	CDD:464251	9/59 (15%)
		CUB	997..1111	CDD:395345	42/213 (20%)
		FXa_inhibition	1118..1153	CDD:464251	12/36 (33%)
		CUB	1158..1267	CDD:395345
		CUB	1271..1390	CDD:238001
Mep1a	NP_032611.2	ZnMc	46..271	CDD:469599	71/231 (31%)
		MAM	281..444	CDD:459878	46/253 (18%)
		MATH	443..607	CDD:445786	36/170 (21%)
		EGF	688..722	CDD:394967	12/35 (34%)