Protein Alignment tok and nas-36

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_492109.2
• Gene: nas-36 / 172506
• WormBaseID: WBGene00003552
• Length: 617
• Species: Caenorhabditis elegans
• Alignment Length: 733
• Identity: 175/733 - (23%)
• Similarity: 267/733 - (36%)
• Gaps: 231/733 - (31%)

  Fly   491 AQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMR 555
            :::|:|   |:||| .|||:   ..|:.|:..:.|...|....|.|....:......:....|:|
 Worm   105 SRRQAV---DILKA-LSKDK---TKRLRRSFVSDKTATWKTMPIKYRFHESIDFYTISQIIAAIR 162

  Fly   556 HWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVV 620
            .||:||||.|.........:||.| ....||.|.:|:.| |.|.||||.:|.|.|::.||:||.:
 Worm   163 FWEDSTCITFENVSDSPDGDYIEF-FSGQGCYSMIGRNG-GRQGISIGESCVKMGVIEHEIGHAL 225

  Fly   621 GFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLD 685
            |.|||.:|||...:|.||.:.|:.....:| :...||:|:||:.||..|:|||....||......
 Worm   226 GLWHEQSRPDALGYVTIERDFILPSYISDF-LQRDDEIDTLGIPYDLGSVMHYGSTAFSVDQKSK 289

  Fly   686 TILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETE 750
            |:  :......:..||||.:||..|:|..|..|...:|                     .|.:|
 Worm   290 TV--VTRDSLYQQTIGQREKLSFYDVATINTAYCKDEC---------------------KSEKT- 330

  Fly   751 HCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSR 815
                            |.||....:.:.|......  ||      |.|..|.|       .|.|:
 Worm   331 ----------------KCENGGYMRPSKCSECLCP--DG------LGGEKCEK-------NEDSK 364

  Fly   816 MLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYP-LDYLPNKECVWKITVPESYQ 879
                             .||    |||.:.:.:....:|||||| ..|..:::|.|.:...:..:
 Worm   365 -----------------NAE----CGGIIKLTEEWKEIESPNYPDPGYEADQKCSWLLKAEKGKR 408

  Fly   880 VALKF-QSFEVENHDSCVYDYVEVRDGPGQDAPLIGV-FCGYKPPPNMKSSGNSMYVKFVS--DT 940
            |.::| :.|......:|| |:||::  ...|....|. ||.|..|.          :.|||  ||
 Worm   409 VEIEFIEDFSFLCTSTCV-DFVELK--ISDDLRNTGFRFCCYDKPE----------ISFVSQTDT 460

  Fly   941 SVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPN 1005
            ::      .:|..::                       |..|||::.:.....|         |.
 Worm   461 AI------IIFRSQL-----------------------STDIGFKIQAKSTDAE---------PR 487

  Fly  1006 GTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGE-NR 1069
            .|| :|:.          |...:||    |::                   |:..|::..|| :.
 Worm   488 TTI-APTI----------ITTTLAP----ITV-------------------DAPNVWADWGEWSM 518

  Fly  1070 LKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFT-DIDECAVNNGGCQHECRNTI 1133
            ..|....||             :|....|.:|.:..|....|.| ::..|.|:    :|..:...
 Worm   519 CSRTCGGCG-------------IRSRVRSCRSKKCEGRRQEFGTCNLKACPVD----KHCAKLLS 566

  Fly  1134 GSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKL 1198
            .:.:|          ||..|.:.:.         .|.|.:.|...||       ||...|
 Worm   567 NNRLC----------NGKVCTKNDI---------AISSCDAPQCCPP-------FINVDG----- 600

  Fly  1199 IFNEFDVESHQECTYDNV 1216
                 ..:|.||..:|.:
 Worm   601 -----VCQSDQENQHDEL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	70/200 (35%)
		CUB	723..836	CDD:412131	16/112 (14%)
		CUB	840..951	CDD:395345	31/115 (27%)
		FXa_inhibition	958..993	CDD:464251	4/34 (12%)
		CUB	997..1111	CDD:395345	19/114 (17%)
		FXa_inhibition	1118..1153	CDD:464251	6/34 (18%)
		CUB	1158..1267	CDD:395345	12/59 (20%)
		CUB	1271..1390	CDD:238001
nas-36	NP_492109.2	Astacin	134..323	CDD:426242	69/193 (36%)
		CUB	380..478	CDD:214483	33/139 (24%)
		TSP1	510..556	CDD:214559	11/58 (19%)