DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tok and nas-36

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	NP_492109.2	Gene:	nas-36 / 172506	WormBaseID:	WBGene00003552	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	175/733 - (23%)
Similarity:	267/733 - (36%)	Gaps:	231/733 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 AQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMR 555
            :::|:|   |:||| .|||:   ..|:.|:..:.|...|....|.|....:......:....|:|
Worm   105 SRRQAV---DILKA-LSKDK---TKRLRRSFVSDKTATWKTMPIKYRFHESIDFYTISQIIAAIR 162

  Fly   556 HWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVV 620
            .||:||||.|.........:||.| ....||.|.:|:.| |.|.||||.:|.|.|::.||:||.:
Worm   163 FWEDSTCITFENVSDSPDGDYIEF-FSGQGCYSMIGRNG-GRQGISIGESCVKMGVIEHEIGHAL 225

  Fly   621 GFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLD 685
            |.|||.:|||...:|.||.:.|:.....:| :...||:|:||:.||..|:|||....||......
Worm   226 GLWHEQSRPDALGYVTIERDFILPSYISDF-LQRDDEIDTLGIPYDLGSVMHYGSTAFSVDQKSK 289

  Fly   686 TILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETE 750
            |:  :......:..||||.:||..|:|..|..|...:|                     .|.:|
Worm   290 TV--VTRDSLYQQTIGQREKLSFYDVATINTAYCKDEC---------------------KSEKT- 330

  Fly   751 HCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSR 815
                            |.||....:.:.|......  ||      |.|..|.|       .|.|:
Worm   331 ----------------KCENGGYMRPSKCSECLCP--DG------LGGEKCEK-------NEDSK 364

  Fly   816 MLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYP-LDYLPNKECVWKITVPESYQ 879
                             .||    |||.:.:.:....:|||||| ..|..:::|.|.:...:..:
Worm   365 -----------------NAE----CGGIIKLTEEWKEIESPNYPDPGYEADQKCSWLLKAEKGKR 408

  Fly   880 VALKF-QSFEVENHDSCVYDYVEVRDGPGQDAPLIGV-FCGYKPPPNMKSSGNSMYVKFVS--DT 940
            |.::| :.|......:|| |:||::  ...|....|. ||.|..|.          :.|||  ||
Worm   409 VEIEFIEDFSFLCTSTCV-DFVELK--ISDDLRNTGFRFCCYDKPE----------ISFVSQTDT 460

  Fly   941 SVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPN 1005
            ::      .:|..::                       |..|||::.:.....|         |.
Worm   461 AI------IIFRSQL-----------------------STDIGFKIQAKSTDAE---------PR 487

  Fly  1006 GTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGE-NR 1069
            .|| :|:.          |...:||    |::                   |:..|::..|| :.
Worm   488 TTI-APTI----------ITTTLAP----ITV-------------------DAPNVWADWGEWSM 518

  Fly  1070 LKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFT-DIDECAVNNGGCQHECRNTI 1133
            ..|....||             :|....|.:|.:..|....|.| ::..|.|:    :|..:...
Worm   519 CSRTCGGCG-------------IRSRVRSCRSKKCEGRRQEFGTCNLKACPVD----KHCAKLLS 566

  Fly  1134 GSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKL 1198
            .:.:|          ||..|.:.:.         .|.|.:.|...||       ||...|
Worm   567 NNRLC----------NGKVCTKNDI---------AISSCDAPQCCPP-------FINVDG----- 600

  Fly  1199 IFNEFDVESHQECTYDNV 1216
                 ..:|.||..:|.:
Worm   601 -----VCQSDQENQHDEL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	70/200 (35%)
		Astacin	527..721	CDD:279708	69/193 (36%)
		CUB	723..836	CDD:294042	16/112 (14%)
		CUB	840..951	CDD:278839	31/115 (27%)
		FXa_inhibition	958..993	CDD:291342	4/34 (12%)
		CUB	997..1111	CDD:278839	19/114 (17%)
		FXa_inhibition	1118..1153	CDD:291342	6/34 (18%)
		CUB	1158..1267	CDD:278839	12/59 (20%)
		CUB	1271..1390	CDD:238001
nas-36	NP_492109.2	Astacin	134..323	CDD:279708	69/193 (36%)
		ZnMc_astacin_like	140..320	CDD:239807	67/184 (36%)
		CUB	380..478	CDD:214483	33/139 (24%)
		TSP1	510..556	CDD:214559	11/58 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810