DRSC/TRiP Functional Genomics Resources

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Protein Alignment tok and TMPRSS6

DIOPT Version :9

Sequence 1:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:NP_001275929.1 Gene:TMPRSS6 / 164656 HGNCID:16517 Length:824 Species:Homo sapiens


Alignment Length:465 Identity:100/465 - (21%)
Similarity:148/465 - (31%) Gaps:169/465 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   807 EVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGG----ELSVDDA--------------VG-- 851
            ||::......||:.||:.....:|   ||::|...|    |.||.|.              ||  
Human   160 EVVQALLVEELLSTVNSS
AAVPYR---AEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQG 221

  Fly   852 ---RLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDS-CVYDYVEVRDGPGQDAPL 912
               ||:.|    |:|.: .|:|.:..|:...:.|:.:....|..|. .:||..    ||.:...:
Human   222 QVLRLKGP----DHLAS-SCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVA----GPLEKRLI 277

  Fly   913 IGVF-CG-YKPPPNMKSSG-----------NSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHG 964
            ..|: |. .:|...:.:||           :|.|..||  .|||...|.|               
Human   278 TSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFV--LSVQPVVFQA--------------- 325

  Fly   965 CEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVA 1029
                         |...:..:...|.:              |.:::|.||..|.....|.|.:..
Human   326 -------------CEVNLTLDNRLDSQ--------------GVLSTPYFPSYYSPQTHCSWHLTV 363

  Fly  1030 PPKHRISLNF---THFDLEGTAHQQSD--CGYDSVTVYSKLGENRLKRIGTFCG--------SSI 1081
            |     ||::   ..||......|:.|  |.....|:     :||     ..||        ..|
Human   364 P-----SLDYGLALWFDAYALRRQKYDLPCTQGQWTI-----QNR-----RLCGLRILQPYAERI 413

  Fly  1082 PPTATSESNALRLEFHSDKSIQRSGFAAVF--FTDIDECAVN-----NGGC------QHECRNTI 1133
            |..||:   .:.:.|.|..|:...|....:  :...|.|...     ||.|      ..:|.|.:
Human   414 PVVATA---GITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGL 475

  Fly  1134 GSYICMCHNGYSMHE------------------NGHD---CKEGECKYEISAPFGTIFSPNYPDS 1177
            ....|:|...:...|                  ||.|   |:||       .|.|| |:....|.
Human   476 DERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEG-------VPCGT-FTFQCEDR 532

  Fly  1178 ---YPPNADC 1184
               ..||..|
Human   533 SCVKKPNPQC 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808
Astacin 527..721 CDD:279708
CUB 723..836 CDD:294042 8/28 (29%)
CUB 840..951 CDD:278839 36/147 (24%)
FXa_inhibition 958..993 CDD:291342 2/34 (6%)
CUB 997..1111 CDD:278839 28/126 (22%)
FXa_inhibition 1118..1153 CDD:291342 12/66 (18%)
CUB 1158..1267 CDD:278839 8/30 (27%)
CUB 1271..1390 CDD:238001
TMPRSS6NP_001275929.1 SEA 77..177 CDD:307516 6/16 (38%)
CUB 326..440 CDD:238001 30/145 (21%)
LDLa 450..480 CDD:238060 5/29 (17%)
LDLa 486..516 CDD:238060 4/29 (14%)
Ldl_recept_a 520..557 CDD:278486 8/24 (33%)
Tryp_SPc 568..822 CDD:238113
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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