Protein Alignment tok and tok

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: XP_061498970.1
• Gene: tok / 1274378
• VectorBaseID: AGAMI1_001152
• Length: 1603
• Species: Anopheles gambiae
• Alignment Length: 1541
• Identity: 746/1541 - (48%)
• Similarity: 927/1541 - (60%)
• Gaps: 304/1541 - (19%)

  Fly    35 NPRP---HRGLPAPAPAPVPASVDQVATENAHRREPTVDGSVLQRLSGSDRAVDEDEDVDEDEDE 96
            |||.   ||..|   ||.:.......||..|.|....|...|:..:     |:::..:..|..:.
Mosquito    12 NPREGCHHRQAP---PATMGNRKPSRATVGAPRPSGWVPAIVMVIV-----AINQLTEGLELNET 68

  Fly    97 GLKHQHLEHRQQFDAYLGTIRRLRRPYRSKYTIEQLMRLHVTPKVSGDIDMDPCKAGGFMGDIAL 161
            .:..:|.:||                    |||::|:.......:||||||||||:.|||||||:
Mosquito    69 LITRRHQQHR--------------------YTIDELLDARFPKSISGDIDMDPCKSSGFMGDIAM 113

  Fly   162 PEGDSGPVVAHTPIDDEEQERQEVEQLLADSPSPVHDPPSVSGAANSGPTKFNATFQLDLEKLKQ 226
            |..:.          :.|.:||                            :.|.:.:.|:.||||
Mosquito   114 PNVNY----------ETEWQRQ----------------------------RMNKSLEQDIVKLKQ 140

  Fly   227 EVYHEGLQVEEEGLTDIIRKKTK----LPSSGPVNLKAG---QSQSQSQSANEPVKPGSESPSDY 284
            |||.|||||||||:||:||||||    .|.||..:...|   .|.:..:|.|. :...|..|...
Mosquito   141 EVYLEGLQVEEEGMTDMIRKKTKQRASTPLSGMTSATGGAYAHSGTSYESENS-ITDSSGEPPVK 204

  Fly   285 AQASSYKNEVLPPSEQRIHTDKPARLTLAEIG----------PKFSNKTQSLH--RNVDTRKIQS 337
            |.....::.::.|.|       |.......:|          ...:||..:..  ||:|..:|||
Mosquito   205 ATIIDNRDNIIVPRE-------PETTFAGGVGGDGERTGEKKATTANKKNATGAVRNIDHDRIQS 262

  Fly   338 DNKDIEDDS------GNNFVAERR-PSQIVPTSLP------------EQRSTPAHV--------- 374
            |.|||..||      .||.|:.|: .:..:||..|            ...|.||.|
Mosquito   263 DTKDIVIDSISDNIISNNHVSSRKVATYALPTKPPTAVTAAAGSHSVSTDSHPAQVAAGSNETKP 327

  Fly   375 ---------YSNAGGNGMQLDDEVDFLHSRGVVRRRHRRGPKQRRSNQH-----LEH-------- 417
                     .:::||||.|  |.|....:|  :||||||   :||..||     .:|
Mosquito   328 MSSILAVGKLASSGGNGEQ--DAVGQAGTR--IRRRHRR---RRRQQQHPRLHDADHTGDDPTSK 385

  Fly   418 --------------------EVKLQRLREEL--------SRPVIEAHHHQSHH------------ 442
                                ..:|:|||.||        .|.:..:||:..||
Mosquito   386 TTSGKTPLNNDGTVVNKNSYHSRLERLRVELGTVTYSVRDRNLRSSHHNPHHHPDEEPLAERSSQ 450

  Fly   443 ----------------QKQAQH-----------------------------------------RQ 450
                            ::..||                                         :|
Mosquito   451 NRTPRKKRRRTRGDSPRRNHQHQDVIANDDRKPPPTANGNDDGNRSEQRANVDIDRASSVDGMKQ 515

  Fly   451 HHQSH------------HRKKHRRQQQHHRRRGQSTTQYVNHSPPG----------FNQSQQA-- 491
            |.::|            ..::||.:.:||....|:...:..|:.|.          |....:|
Mosquito   516 HGEAHGYDKSYHPRAQPQHQQHRHRSEHHHLHEQAHGTHFTHAEPNVGADNGMNLHFRPDHKAPA 580

  Fly   492 ---QQQSVPEMDLLKAETSKD------------------EEPLRHRVARAVTAKKERIWDYGVIP 535
               :.|..||...|..|...|                  |....||..||.|||||||||:||||
Mosquito   581 LAGKAQDPPEPQHLPVEDDIDDDEADSGHIYYASARDEHEHQQHHRTIRAATAKKERIWDFGVIP 645

  Fly   536 YEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAI 600
            |||||||||:|||||:.|||||||.||||||||:|..||||||||.|:|||||||||||||||||
Mosquito   646 YEIDGNFSGMHKALFRQAMRHWENYTCIKFVERNPIDHPNYIVFTERACGCCSFVGKRGNGPQAI 710

  Fly   601 SIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAY 665
            |||:||||||||||||||||||||||||||||.|||||.|||:.||:||||.|:.|||:|||:.|
Mosquito   711 SIGKNCDKFGIVVHELGHVVGFWHEHTRPDRENHVVIEKNNIVVGQEYNFNKLTEDEVNSLGLPY 775

  Fly   666 DYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQES 730
            ||||||||||||||||||||||.||||.||||||||||||||:||||||||||||.||||||||:
Mosquito   776 DYDSIMHYARNTFSKGTYLDTIFPIEMPGRKRPEIGQRLRLSEGDIAQANLLYKCAKCGRTFQEN 840

  Fly   731 SGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSP 795
            |..|.||::|:. ....|.|.||||||||:|||:.|.:.:::|:|||:|.:|||||||||:.|||
Mosquito   841 SASFTSPTYYST-TPPTEPERCEWRITATHGERIVLNITDLDIYKSNSCRSDYLEIRDGYWHKSP 904

  Fly   796 LIGRFC--GKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNY 858
            ::|:||  |||: |:||:..|||||||..|.|....|||.|.::.:|||:::::.. ||||||||
Mosquito   905 ILGKFCGSGKVN-ELIRSTGSRMLLTYTTTFRQASMRGFAANYEAICGGDMNLESG-GRLESPNY 967

  Fly   859 PLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPP 923
            |:||||||||:|:||||:.||||||||||||||||:|||||||||||...|:.|||||||||.||
Mosquito   968 PVDYLPNKECIWRITVPKDYQVALKFQSFEVENHDNCVYDYVEVRDGGSADSRLIGVFCGYKIPP 1032

  Fly   924 NMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYECSCRIGFELHS 988
            :|||:.|.::||||||.|||||||||.|||||||||..:||||||||||||||||:|.||:||||
Mosquito  1033 DMKSTSNKLFVKFVSDGSVQKAGFSATFMKEVDECEHMDHGCEHECINTLGGYECACYIGYELHS 1097

  Fly   989 DKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEG-TAHQQS 1052
            |||.||:||||.::.|||||.|||||:.||::|||:|||||.|:|:|:|||||||||| |.:|.|
Mosquito  1098 DKKSCENACGGQLDTPNGTILSPSFPKEYPIMKECVWEIVALPQHKITLNFTHFDLEGNTFYQAS 1162

  Fly  1053 DCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDE 1117
            :|.||.|.|.||..:..|.:.|::||.::|...|||.|.||:.|.|||:||::|||||:||||||
Mosquito  1163 ECEYDYVAVLSKSPDGTLHKHGSYCGYTVPAPITSEWNILRVVFKSDKTIQKTGFAAVYFTDIDE 1227

  Fly  1118 CAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNA 1182
            |||||||||.||:||:|||:|.|.|||::|:|||||||..||:||..|.|.|.||||||.|||..
Mosquito  1228 CAVNNGGCQQECKNTVGSYVCSCRNGYTLHDNGHDCKESGCKHEIFTPHGQILSPNYPDYYPPKK 1292

  Fly  1183 DCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQ 1247
            ||:|||.|||||||:|:||.||:|.||||.||::.:|||.|..|..||||||.|||.||||:|||
Mosquito  1293 DCIWHFTTTPGHRIRLVFNVFDIEPHQECAYDHIVIYDGNSPDSHTLGRFCGAKIPHPISSSSNQ 1357

  Fly  1248 MYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSY 1312
            ||||..||.:.|:.||.|||||||||.|:||.....||||.:||:..|::|.||||||.|.....
Mosquito  1358 MYMVFNTDTSVQRKGFFASHSTACGGRLKATEVKNHFYSHIKFGSGMYENGADCEWTIVADSGQN 1422

  Fly  1313 VQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVL 1358
            |||.||:|::|..:.|::|||:|:..:||   :.||::|:||||.:
Mosquito  1423 VQLKFLSFELEEEKMCSYDYVEVYGGLDD---ESGPLHGKYCGNAV 1465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	174/200 (87%)
		CUB	723..836	CDD:412131	65/114 (57%)
		CUB	840..951	CDD:395345	83/110 (75%)
		FXa_inhibition	958..993	CDD:464251	28/34 (82%)
		CUB	997..1111	CDD:395345	67/114 (59%)
		FXa_inhibition	1118..1153	CDD:464251	25/34 (74%)
		CUB	1158..1267	CDD:395345	71/108 (66%)
		CUB	1271..1390	CDD:238001	42/88 (48%)
tok	XP_061498970.1	None