Protein Alignment tok and Bmp1

DIOPT Version :10

• Sequence 1: NP_476879.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: NP_033885.2
• Gene: Bmp1 / 12153
• MGIID: 88176
• Length: 991
• Species: Mus musculus
• Alignment Length: 884
• Identity: 448/884 - (50%)
• Similarity: 611/884 - (69%)
• Gaps: 30/884 - (3%)

  Fly   514 RHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIV 578
            |.|..||.|::.||:|..||||:.|.|||:|..:|:|:.||||||..||:.|:||..|  .:|||
Mouse   120 RPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE--DSYIV 182

  Fly   579 FTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIM 643
            ||.|.|||||:||:||.||||||||:|||||||||||||||:|||||||||||::||.|...||.
Mouse   183 FTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDRHVSIVRENIQ 247

  Fly   644 KGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILP-IEMKGRKRPEIGQRLRLS 707
            .||:|||..:...||:|||..||:||||||||||||:|.:||||:| .|:.|.| |.||||.|||
Mouse   248 PGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVK-PSIGQRTRLS 311

  Fly   708 QGDIAQANLLYKCPKCGRTFQESSGIFASPSH---YTAGALSNETEHCEWRITATYGERVELKLE 769
            :||||||..|||||.||.|.|:|:|.|:||.:   |:|..      ||.|||:.|.||::.|...
Mouse   312 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHM------HCVWRISVTPGEKIILNFT 370

  Fly   770 NMNIFKSNNCETDYLEIRDGYFEKSPLIGRFC-GKVDKEVIRTESSRMLLTYVNTHRIEGFRGFK 833
            :|::::|..|..||:|:|||::.|:||.|||| ||:.:.::.|: ||:.:.:.::....| :||.
Mouse   371 SMDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGGKLPEPIVSTD-SRLWVEFRSSSNWVG-KGFF 433

  Fly   834 AEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYD 898
            |.::.:|||::..|:  |.::|||||.||.|:|.|:|:|.|.|.:.|.|.|||||:|.||||.||
Mouse   434 AVYEAICGGDVKKDN--GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 496

  Fly   899 YVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNH 963
            |:|||||..:.:.|||.:|||:.|.::||:.:.:::|||||.|:.||||:..|.||||||...|.
Mouse   497 YLEVRDGHSESSNLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNR 561

  Fly   964 -GCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEI 1027
             |||..|:||||.|:|||..|:||..||:.||.||||.:...||:||||.:|:.||..|.|||::
Mouse   562 GGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 626

  Fly  1028 VAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKL-GENRLKRIGTFCGSSIPPTATSESNA 1091
            |||.::||||.|..|:.||    ...|.||.|.|.|.| .:::|.  |.||||..|...||:.|.
Mouse   627 VAPTQYRISLQFDFFETEG----NDVCKYDFVEVRSGLTADSKLH--GKFCGSEKPEVITSQYNN 685

  Fly  1092 LRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEG 1156
            :|:||.||.::.:.||.|.||:|.|||:.:|||||.:|.||.|||.|.|.:|:.:|:|.|||||.
Mouse   686 MRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEA 750

  Fly  1157 ECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDG 1221
            .|::::::..|||.|||:||.||...:|.|...:|||||:||.|.|.|:||..||.||::.|:||
Mouse   751 GCEHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDG 815

  Fly  1222 ESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYS 1286
            ....:.|||||||.|.|.|:.:|.|:|::...:|.:.|:.||.|||||.|||.:||..:.:..||
Mouse   816 RDAKAPVLGRFCGSKKPEPVLATGNRMFLRFYSDNSVQRKGFQASHSTECGGQVRADVKTKDLYS 880

  Fly  1287 HARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYG 1351
            ||:||:.:|..|:||||.|.|.:...|:|:|.||::|...:|.:||:::|    |.|....|..|
Mouse   881 HAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYIELF----DGYDSTAPRLG 941

  Fly  1352 QYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVA 1390
            :|||:..|:::.|...|:||:|.:|.::..|||...|.:
Mouse   942 RYCGSGPPEEVYSAGDSVLVKFHSDDTISKKGFHLRYTS 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_476879.1	ZnMc_BMP1_TLD	520..721	CDD:239808	132/201 (66%)
		CUB	723..836	CDD:412131	45/116 (39%)
		CUB	840..951	CDD:395345	58/110 (53%)
		FXa_inhibition	958..993	CDD:464251	19/35 (54%)
		CUB	997..1111	CDD:395345	52/114 (46%)
		FXa_inhibition	1118..1153	CDD:464251	18/34 (53%)
		CUB	1158..1267	CDD:395345	50/108 (46%)
		CUB	1271..1390	CDD:238001	47/118 (40%)
Bmp1	NP_033885.2	ZnMc_BMP1_TLD	126..325	CDD:239808	132/201 (66%)
		CUB	327..436	CDD:395345	45/116 (39%)
		CUB	440..549	CDD:395345	58/110 (53%)
		FXa_inhibition	560..592	CDD:464251	18/31 (58%)
		CUB	596..705	CDD:395345	52/114 (46%)
		FXa_inhibition	712..747	CDD:464251	18/34 (53%)
		CUB	752..861	CDD:395345	50/108 (46%)
		CUB	865..978	CDD:395345	46/116 (40%)