DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tok and LOC100495742

DIOPT Version :9

Sequence 1:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster
Sequence 2:	XP_031751324.1	Gene:	LOC100495742 / 100495742	-ID:	-	Length:	1005	Species:	Xenopus tropicalis

Alignment Length:	896	Identity:	467/896 - (52%)
Similarity:	627/896 - (69%)	Gaps:	30/896 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 KAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVE 567
            ||:|::..:..:.|..||.|::.||||..|||||.|.|||:|..:|:||.||||||..||:.|:|
Frog   124 KADTTQSWKSKKIRTPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIE 188

  Fly   568 RDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDRE 632
            |..|  .:|||||.|.|||||:||:|||||||||||:|||||||||||||||:|||||||||||:
Frog   189 RTDE--ESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRD 251

  Fly   633 KHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKR 697
            .||.|...||..||:|||..:.|.||:|||.:||:||||||||||||:|.:||||||...:...|
Frog   252 DHVTIIRENIQPGQEYNFLKMEPGEVNSLGESYDFDSIMHYARNTFSRGMFLDTILPSRDENGLR 316

  Fly   698 PEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPS------HYTAGALSNETEHCEWRI 756
            |.||||.|||:||||||..||:||.||.|.|||:|.|:||.      .||         ||.|||
Frog   317 PPIGQRTRLSKGDIAQARKLYRCPACGETLQESTGNFSSPGFPNGYPSYT---------HCIWRI 372

  Fly   757 TATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYV 821
            :.|.||::.|....|:::||:.|..||:|:||||::||||:|||||....||:.:..|||.:.:.
Frog   373 SVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWKKSPLLGRFCGDKLPEVLTSTDSRMWIEFR 437

  Fly   822 NTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQS 886
            ::....| :||.|.::.:||||:..|  .|:::|||||.||.|.|||||||||.|:|.|.|.||:
Frog   438 SSSNWVG-KGFAAVYEAICGGEIHKD--AGQIQSPNYPDDYRPLKECVWKITVAENYNVGLTFQA 499

  Fly   887 FEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVF 951
            ||:|.||||.|||:|||||..:::||||.||||..|.:::|:.|::::|||||.:|.||||:|.|
Frog   500 FEIERHDSCAYDYLEVRDGSSENSPLIGHFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 564

  Fly   952 MKEVDEC-ETQNHGCEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPE 1015
            :||.||| ...|.|||..|:||||.|:|||..|:||..|||.||.||||::...|||||:|::|:
Frog   565 LKEEDECARPDNGGCEQRCVNTLGSYKCSCDPGYELGPDKKSCEAACGGLLTKLNGTITTPAWPK 629

  Fly  1016 MYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSS 1080
            .||..|.|:|::|||.::|||:.|.:|:|||    ...|.||.|.|.|.|..:. |..|.|||:.
Frog   630 EYPPNKNCVWQVVAPSQYRISMKFDYFELEG----NEVCKYDYVEVRSGLSSDS-KLHGKFCGTE 689

  Fly  1081 IPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYS 1145
            :|...||:.|.:|:||.||.::.:.||.|.||:|.|||:.:||||||||.||||||:|.|.||:.
Frog   690 VPEVITSQYNNMRIEFKSDNTVSKKGFRAHFFSDKDECSKDNGGCQHECINTIGSYVCQCRNGFV 754

  Fly  1146 MHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQE 1210
            :|||.|||||.||::.|.:|.|.|.|||:||.||...:|.|....|||||:||.|:||::|.|||
Frog   755 LHENKHDCKEAECEHRIHSPNGVITSPNWPDKYPSRKECTWEISATPGHRVKLSFSEFEIEQHQE 819

  Fly  1211 CTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYL 1275
            |.||::.|:|||:|.||:|||.||.|||.|:.:|.|:|::...:|.:.|:.||.|:|||.|||.|
Frog   820 CAYDHLEVFDGETEKSSILGRLCGSKIPEPLVATGNKMFLRFVSDASVQRKGFQATHSTECGGRL 884

  Fly  1276 RATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDID 1340
            :|.::.:..:|||:||:.:|....||||.:|......::|.|.||::|...:|.:|::::|
Frog   885 KAEAKSRDLFSHAQFGDNNYPVQADCEWMLATERGLRIELSFQTFEVEEEADCGYDFMELF---- 945

  Fly  1341 DVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAV 1391
            |.:.......|::||:..|::|.|...::|:.|.||.::..|||...|.:|
Frog   946 DGHDASAMRLGRFCGSGPPEEIISTGDAILIHFHTDDTISKKGFHIRYKSV 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	135/200 (68%)
		Astacin	527..721	CDD:279708	132/193 (68%)
		CUB	723..836	CDD:294042	50/118 (42%)
		CUB	840..951	CDD:278839	66/110 (60%)
		FXa_inhibition	958..993	CDD:291342	20/35 (57%)
		CUB	997..1111	CDD:278839	50/113 (44%)
		FXa_inhibition	1118..1153	CDD:291342	23/34 (68%)
		CUB	1158..1267	CDD:278839	55/108 (51%)
		CUB	1271..1390	CDD:238001	39/118 (33%)
LOC100495742	XP_031751324.1	ZnMc_BMP1_TLD	141..340	CDD:239808	135/200 (68%)
		CUB	342..451	CDD:395345	50/118 (42%)
		CUB	455..564	CDD:395345	66/110 (60%)
		FXa_inhibition	575..607	CDD:405372	19/31 (61%)
		CUB	611..720	CDD:395345	50/113 (44%)
		FXa_inhibition	727..762	CDD:405372	23/34 (68%)
		CUB	767..876	CDD:395345	55/108 (51%)
		CUB	880..993	CDD:395345	38/116 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49202
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010