Protein Alignment tok and cubn

DIOPT Version :9

• Sequence 1: NP_001287510.1
• Gene: tok / 42944
• FlyBaseID: FBgn0004885
• Length: 1464
• Species: Drosophila melanogaster
• Sequence 2: XP_021326049.1
• Gene: cubn / 100144772
• ZFINID: ZDB-GENE-060228-6
• Length: 3626
• Species: Danio rerio
• Alignment Length: 833
• Identity: 241/833 - (28%)
• Similarity: 371/833 - (44%)
• Gaps: 181/833 - (21%)

  Fly   721 PKCGRTFQESSGIFAS---PSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETD 782
            |.||..|.|:.||..|   |::|.      ....|.:.|.....|:|.|...:|::.....|..|
Zfish   709 PGCGGVFTETEGIIISPNWPNNYA------HNRQCIYIIRMPRSEQVALNFTHMDLEIHTGCLFD 767

  Fly   783 YLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVD 847
            ::|:|||..|..||||::||......|.:.::.:.:.:.:...:.. .||:|.:::.|||.||
Zfish   768 FVEVRDGTGETDPLIGKYCGNTLPAPILSTTNGLWIRFQSDSSVSR-AGFRAMYELACGGTLS-- 829

  Fly   848 DAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPL 912
             ..|::.:|.:|..|..||.|.|.|..||.|.|.|.|.:|:||...:|.:|:|||||||...:||
Zfish   830 -GTGQIRTPFHPDPYPHNKVCEWVINQPEGYVVTLNFLTFDVEGSSTCAFDHVEVRDGPSSSSPL 893

  Fly   913 IGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNHGCEHECINTLGGYE 977
            ||.:||.:.||.::|:..||:::|.:|.||...||:|.|
Zfish   894 IGRYCGVEMPPMLESTQKSMFIQFKTDASVSNHGFTAEF-------------------------- 932

  Fly   978 CSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHF 1042
                         ...|..||..:..|.|:.|||..|..||....|.|.|..||.|.|.|:|::|
Zfish   933 -------------GSAEQGCGETLTEPTGSFTSPGHPTEYPHGANCTWYISVPPGHLIRLSFSYF 984

  Fly  1043 DLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGF 1107
            ::|    ..::|.||.|.||..........:|.|||.|:||:.||..:.:.:...||.|:...||
Zfish   985 NME----FHTNCAYDYVDVYDNGTALTGTLLGRFCGRSVPPSLTSTDSLMTVLLVSDSSLSAEGF 1045

  Fly  1108 AA-------------VF-------------------------------------FTD-------- 1114
            :|             ||                                     |||
Zfish  1046 SADYISINATTDCSKVFRTSTGELSSPNYPDNYPTNRECVYRIIVEVNMQIMLNFTDFQLEGFSS 1110

  Fly  1115 --IDECAVNNGGCQHECRNTIGSY-------ICMCHN----------------GYSMHENGHDCK 1154
              .|...:.:||  :|....||.|       |.:.|:                |:..|.:|   .
Zfish  1111 CGFDYLEIRDGG--YETSPLIGQYCGTNAPPIIVSHSNRLWMKFRSDHSLTYRGFQAHWDG---T 1170

  Fly  1155 EGECKYEISAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVY 1219
            :..|...::...|...|||||..||.||:|.||..|:.|.||:|.|.:|.:|...:|.:|.:.||
Zfish  1171 QTGCGGTLTTSSGGFTSPNYPLPYPANAECYWHIKTSAGSRIQLSFGDFHLEDTVDCYFDYLMVY 1235

  Fly  1220 DGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYL---RATSQV 1281
            ||.:.::..|.:.||::||.||||:...||:.|:||......||.|::.:.|.|.|   |:...:
Zfish  1236 DGNNSNAHQLAKLCGNQIPAPISSSRENMYVKLRTDSIIHTGGFLANYHSTCNGMLIANRSRGMI 1300

  Fly  1282 QQFYSHARFGNQDYDDGMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQY 1346
            :..    .:.| ||....||.|||.|...:.:...|:.|::|.|:.|.:|:|:::...:|    .
Zfish  1301 ESL----NYPN-DYPSHADCSWTIQAYMGNTINYTFIAFEVEQSDGCGYDHVKLYDGPND----Q 1356

  Fly  1347 GPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASY------------VAVPNS----G 1395
            ..:.|.:||||.|....:...||.:.|::|.|:..:||...:            |...||    |
Zfish  1357 ANLIGTFCGNVPPPAGTTSGTSLHIVFRSDMSISYRGFQMDWYQNGCGGELFGPVGTFNSPGYPG 1421

  Fly  1396 EYDHSDEDVENSYSSEMVTPFPGSLKSIYIEDTQEETDEYSDFSGNQL-VFNG 1447
            :|..:.|.|.:.::|      |||  ||.|...:.:.:.:.|.:.::| |:.|
Zfish  1422 QYPMNRECVWHIHTS------PGS--SISITILEFDVEYHPDCNYDKLEVYGG 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	241/833 (29%)
		Astacin	527..721	CDD:279708	241/833 (29%)
		CUB	723..836	CDD:294042	32/115 (28%)
		CUB	840..951	CDD:278839	50/110 (45%)
		FXa_inhibition	958..993	CDD:291342	0/34 (0%)
		CUB	997..1111	CDD:278839	42/126 (33%)
		FXa_inhibition	1118..1153	CDD:291342	11/57 (19%)
		CUB	1158..1267	CDD:278839	45/108 (42%)
		CUB	1271..1390	CDD:238001	34/133 (26%)
cubn	XP_021326049.1	EGF_CA	133..164	CDD:238011
		EGF_CA	167..208	CDD:238011
		EGF_CA	260..299	CDD:311536
		EGF_3	308..346	CDD:315598
		EGF_3	352..387	CDD:315598
		EGF_CA	397..430	CDD:238011
		EGF_CA	433..469	CDD:238011
		CUB	475..588	CDD:238001
		CUB	593..704	CDD:238001
		CUB	711..820	CDD:278839	32/115 (28%)
		CUB	824..932	CDD:238001	50/110 (45%)
		CUB	939..1049	CDD:278839	42/113 (37%)
		CUB	1058..1166	CDD:278839	15/109 (14%)
		CUB	1174..1285	CDD:238001	45/110 (41%)
		CUB	1287..1399	CDD:238001	34/120 (28%)
		CUB	1403..1515	CDD:238001	18/72 (25%)
		CUB	1522..1632	CDD:238001
		CUB	1635..1750	CDD:238001
		CUB	1755..1865	CDD:238001
		CUB	1869..1979	CDD:238001
		CUB	1994..2105	CDD:238001
		CUB	2108..2223	CDD:238001
		CUB	2228..2344	CDD:238001
		CUB	2347..2458	CDD:238001
		CUB	2463..2575	CDD:238001
		CUB	2581..2694	CDD:238001
		CUB	2697..2808	CDD:238001
		CUB	2813..2926	CDD:238001
		CUB	2928..3038	CDD:238001
		CUB	3041..3152	CDD:238001
		CUB	3161..3274	CDD:278839
		CUB	3281..3395	CDD:238001
		CUB	3399..3509	CDD:238001
		CUB	3514..3626	CDD:238001

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586709
Domainoid	1	1.000	93	1.000	Domainoid score	I7493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840