DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tok and cubn

DIOPT Version :9

Sequence 1:NP_001287510.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster
Sequence 2:XP_012821080.2 Gene:cubn / 100125884 XenbaseID:XB-GENE-957007 Length:3631 Species:Xenopus tropicalis


Alignment Length:1384 Identity:305/1384 - (22%)
Similarity:469/1384 - (33%) Gaps:538/1384 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   555 RHWENSTCIKFVERDPE--IHPNYIVFTVRSCGCC--------------SFV-GKR-GNG-PQAI 600
            :|....:|:..::.:|.  :|..:..|.:.....|              ||: ||. |.| ||.|
 Frog   497 QHGHMLSCMWVIKTEPRKILHITFTNFHLEQSTPCRTEFLQVHDGDSISSFILGKYCGTGVPQEI 561

  Fly   601 SIGRNCDKFGIVVHELGHVVGF---WHEHTRPDREKHVVIEHNNIMK---------GQD------ 647
            |...|...|......:....||   | |..:|:....::..|.:||.         .:|      
 Frog   562 SSSHNSLFFWFHSDHISSAGGFRISW-ESRQPECGGELMETHGSIMSPGYPGNYPPNRDCYWTIS 625

  Fly   648 --------YNFNMLSPDEVDSLGMAYDY----DSIMHYARNTFSKGTYLDTILPIEMK------- 693
                    :.|..||.::.::.|.  ||    |.::...|   ..|.|..|:.|..::       
 Frog   626 TNPGLYITFAFGTLSLEDHENCGK--DYLEIRDGLLPQDR---VLGKYCSTLSPAPLQTSGPYAW 685

  Fly   694 -----GRKRPEIGQRLRL--SQGDIAQANLLYKCPKCGRTFQESSGIFAS---PSHYTAGALSNE 748
                 |....:.|..:..  |..|          |.||..|.::.|..:|   |..||.      
 Frog   686 LHFHSGNTGEDRGFHITYIS
SPSD----------PGCGGNFTDNEGFISSPRWPQPYTG------ 734

  Fly   749 TEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTES 813
            .:.|.:.|.....|::.|:..|:.:..|:.|...|:|||||..|.:|||||:|.......|.:.|
 Frog   735 NKQCIYIIQQPANEKISLRFTNLELENSSGCSLSYMEIRDGDTETAPLIGRYCNTTIPPPISSSS 799

  Fly   814 SRMLLTYVNTHRIEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESY 878
            :.:.:.:.:...:.. ..|||.:.|.|||.|:   ..|.:.:|:||..|...:.|.|.||.||..
 Frog   800 NALWIKFKSDASVTR-SSFKAFY
QVACGGFLT---GAGVIHTPHYPDAYFRERTCEWIITQPEGE 860

  Fly   879 QVALKFQSFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQ 943
            .|:|.|.||::....:|..::||:|||...|:||||.:||.:.|...:|:..::|::|.:|:|..
 Frog   861 VVSLTFNSFDILAGTNCGSNFVEIRDGSSSDSPLIGKYCGPEMPVPAQSTQRALYIRFTTDSSAT 925

  Fly   944 KAGFSAVFMKEVDEC-----ETQN------------HG--C---------------------EH- 967
            ..|||..:...::.|     :||.            ||  |                     || 
 Frog   926 NHGFSISYQS
LIEGCGGTLTDTQGTITSPGYPAVYPHGIQCTWFISIPPGNLIRLTFDSFNLEHG 990

  Fly   968 ----------------------------------------------------------------- 967
                                                                             
 Frog   991 YSCSYDYLDIYDSASAIMESRIGRFCGRSIPPSITSRGNTMTVLLVTDTNTAVEGFSARYTSLNA 1055

  Fly   968 ----------------------------ECINTL------------------------------- 973
                                        |||.|:                               
 Frog  1056 TTACDASYTEASGIFSSPNYPNRYPNNLECIYTITVETNKQILLNFTTFVLSTSTNCDKDHVEIR 1120

  Fly   974 -GGYECSCRIG---------FELHSDK-----------------KHCEDA---CGGVIEYPNGTI 1008
             ||||.|..:|         ...||:|                 .|.:.|   |||.:...:|..
 Frog  1121 DGGYEISPLLGKFCQGPPPVIVSHSNKLWVKFRSDSSYSETGFSAHWDSATTGCGGTLTSVSGGF 1185

  Fly  1009 TSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSD--CGYDSVTVYSKL------ 1065
            |||:||..|....||.|:::|.......:.|.|||||..::.|:|  ..||..|.:|.|      
 Frog  1186 TSPNFPMPYYHNSECYWQMMASSGSTFEIQFEHFDLESHSNCQNDYLAVYDGNTTHSHLLEKLCG 1250

  Fly  1066 ----------GEN---------------------------------------------------- 1068
                      |.|                                                    
 Frog  1251 KRLPDPIRSSGSNVYVKFRTDNSISFSGFFATYKQTCQGVMIANRSRGILESLNYPNSYPHNQQC 1315

  Fly  1069 ---------------------------------------RLKRIGTFCGSSIPPTATSESNALRL 1094
                                                   :.:.|||:||:.:||:.|:...:|.:
 Frog  1316 NWTIQATLGNTINYTFTTFNVEGYFSCNDYVQLYDGPDKQARLIGTYCGNQLPPSGTTTGTSLHV 1380

  Fly  1095 EFHSDKSIQRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSM-HENGHDC----- 1153
            .||||.:|.|.||...::.:         ||..|.....||:   ...|:.| :.:..:|     
 Frog  1381 VFHSDDTITRPGFQMQWYVN---------GCGEELSGPFGSF---TSPGFPMRYPDNRECIWHIQ 1433

  Fly  1154 -----------------KEGECKYEI--------------------------------------- 1162
                             ....|.|::                                       
 Frog  1434 TSPGSSIQITIWEFNIEYHSTCSYDVLEIYGGPGVSSPRLAQLCAPRPQENPLQVSSTGNTMTVR 1498

  Fly  1163 ---------------------------SAPFGTIFSPNYPDSYPPNADCVWHFITTPGHRIKLIF 1200
                                       .||.|.|.|||||..|..|.:|.|......|||:.|.|
 Frog  1499 FKTDAYVSGRGFNTTWREIPGGCGGVFQAPNGEIHSPNYPRPYEDNTECSWVIRVDFGHRVLLTF 1563

  Fly  1201 NEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTA 1265
            .:||:|||..|::|:|.|:||....:..|...||.::|..||||.|.|::.|::|.:.|..||:|
 Frog  1564 RDFDIESHSSCSFDSVTVFDGPDNEADPLAVLCGTQLPAAISSTQNTMFVRLRSDGSNQHRGFSA 1628

  Fly  1266 SHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWTIAAPD-NSYVQLIFLTFDIE-SSENC 1328
            ..:.|||..:.|.|......|.....|  |.:..:|.|.|.|.: .::|.|.|...:|| .::||
 Frog  1629 KFTEACGSLITADSIGATISSPLYPAN--YPNNQNCMWIIQAQEPYNHVTLSFTDLEIEFRNDNC 1691

  Fly  1329 TFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVA--- 1390
            |.|||::.    |......|:.|:|||..:|..|.|.:::|:|:|.::.|...|||.|::.|   
 Frog  1692 TLDYVEIL----DGNNPDAPVQGRYCGRTIPHPITSFSNALVVKFVSNNSTSAKGFHATFAASTS 1752

  Fly  1391 --------------VPNSGE-YDHSDEDVENSYSSEMVTPFPGS-LKSIYIEDTQEETDEYS-DF 1438
                          .|:..| |..:.|.|.|..||      ||: |...:|..:.:.:|..| |:
 Frog  1753 ACGGTLHMETGAFNSPSYPENYPANTECVWNILSS------PGNRLLLSFITFSVQHSDSCSHDY 1811

  Fly  1439 ----SGNQLVFNGQYRGRY 1453
                .||:   .|...||:
 Frog  1812 LEIREGNE---TGSLMGRF 1827

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tokNP_001287510.1 ZnMc_BMP1_TLD 520..721 CDD:239808 43/228 (19%)
Astacin 527..721 CDD:279708 43/228 (19%)
CUB 723..836 CDD:294042 33/115 (29%)
CUB 840..951 CDD:278839 42/110 (38%)
FXa_inhibition 958..993 CDD:291342 21/226 (9%)
CUB 997..1111 CDD:278839 46/222 (21%)
FXa_inhibition 1118..1153 CDD:291342 7/35 (20%)
CUB 1158..1267 CDD:278839 47/174 (27%)
CUB 1271..1390 CDD:238001 39/120 (33%)
cubnXP_012821080.2 cubilin_NTD 28..133 CDD:412063
EGF_CA <138..166 CDD:238011
EGF_CA 169..210 CDD:238011
EGF_CA 262..305 CDD:214542
EGF_CA 306..349 CDD:214542
EGF_3 354..388 CDD:403986
EGF_CA 398..432 CDD:238011
EGF_CA 434..470 CDD:238011
CUB 476..589 CDD:238001 21/92 (23%)
CUB 594..705 CDD:238001 18/115 (16%)
CUB 712..821 CDD:395345 33/115 (29%)
CUB 825..935 CDD:238001 42/112 (38%)
CUB 940..1052 CDD:238001 8/111 (7%)
CUB 1059..1167 CDD:238001 13/107 (12%)
CUB 1174..1283 CDD:238001 29/108 (27%)
CUB 1287..1399 CDD:238001 17/111 (15%)
CUB 1402..1515 CDD:238001 9/115 (8%)
CUB 1521..1631 CDD:238001 45/109 (41%)
CUB 1634..1749 CDD:238001 39/120 (33%)
CUB 1754..1864 CDD:238001 20/83 (24%)
CUB 1868..1976 CDD:238001
CUB 1994..2104 CDD:238001
CUB 2108..2228 CDD:238001
CUB 2233..2347 CDD:238001
CUB 2352..2461 CDD:238001
CUB 2468..2580 CDD:238001
CUB 2586..2702 CDD:238001
CUB 2705..2816 CDD:238001
CUB 2821..2931 CDD:238001
CUB 2933..3041 CDD:238001
CUB 3044..3154 CDD:395345
CUB 3164..3279 CDD:238001
CUB 3284..3399 CDD:238001
CUB 3402..3514 CDD:238001
CUB 3519..3631 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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