DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13630 and Pa2g4

DIOPT Version :9

Sequence 1:	NP_651281.1	Gene:	CG13630 / 42943	FlyBaseID:	FBgn0039219	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_035249.1	Gene:	Pa2g4 / 18813	MGIID:	894684	Length:	394	Species:	Mus musculus

Alignment Length:	190	Identity:	48/190 - (25%)
Similarity:	82/190 - (43%)	Gaps:	30/190 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DHPAGRSLSEEALRGTKIKVLDDEEIEGMRVAGRLGRECLDEGAKAVEVGITTDELDRLVHEAA- 161
            |....::::|: |..||.|:       |..:|.|:.|..::..:..|.|....::.|.::.|..
Mouse     5 DEQQEQTIAED-LVVTKYKM-------GGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETG 61

  Fly   162 ----IERECYPSPLNYYNFPKSCCTSVNEVICHGIP---DQ-RPLQDGDLCNIDVTVYHRGFHGD 218
                .|:|....    ..||.|  .|||..:||..|   || ..|::|||..||:.|:..||..:
Mouse    62 KIFKKEKEMKKG----IAFPTS--ISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIAN 120

  Fly   219 LNETFFVG-----NVSEKHKKLVQVTHEALSKAIEFVRPGEKYRDIGNVIQKYVAPHGFS 273
            :..||.:|     .|:.:...:::..|.....|:..|:||.:...:.....|  ..|.|:
Mouse   121 VAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNK--VAHSFN 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13630	NP_651281.1	zf-C6H2	9..48	CDD:292429
		PLN03158	10..369	CDD:215607	48/190 (25%)
		MetAP1	123..360	CDD:238519	42/165 (25%)
Pa2g4	NP_035249.1	crvDNA_42K	1..388	CDD:273105	48/190 (25%)
		Necessary for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:Q9UQ80	2..48		12/50 (24%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9UQ80	46..54		0/7 (0%)
		Necessary for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:Q9UQ80	301..394
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..394
		Interaction with RNA. /evidence=ECO:0000269\|PubMed:17690690	361..375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810