Protein Alignment slo and Kcnma1

DIOPT Version :10

• Sequence 1: NP_001262924.1
• Gene: slo / 42940
• FlyBaseID: FBgn0003429
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_063130769.1
• Gene: Kcnma1 / 83731
• RGDID: 620715
• Length: 1320
• Species: Rattus norvegicus
• Alignment Length: 1213
• Identity: 652/1213 - (53%)
• Similarity: 800/1213 - (65%)
• Gaps: 149/1213 - (12%)

  Fly    30 RKYWCFLLSSIFTFLAGLLVVLLWRAFAF---VCCRKEPDLGPNDPKQKE-QKASRNKQEFEGT- 89
            |.:|.||.||:.||..||.::||||...:   |||.       ...|.|| ||.:....:.:||
  Rat    85 RMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH-------CGGKTKEAQKINNGSSQADGTL 142

  Fly    90 ---------------FMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERC 139
                           :||..|||||.:||.||.|||:||||||.|||.:|:|||:| ||..:|.|
  Rat   143 KPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFID-SSNPIESC 206

  Fly   140 QKWSNNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGL 204
            |.:..:.|.|||:|||:||::||.:|||||:|||||.||:.|.||:||:||.|||:||:|:|:||
  Rat   207 QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGL 271

  Fly   205 RFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGDPLD-FNNAHR 268
            ||||||||:...:|||:||:||||:||:|..|:|||||.||||||.|||:||||||.: |.|...
  Rat   272 RFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQA 336

  Fly   269 LSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAVFASWIPEITELAAQRSKYGGTY 333
            |:||.|||.|:||||||||||||.:|.|||.|:|||:|.|||:|||::|||.||...|.||||:|
  Rat   337 LTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSY 401

  Fly   334 SKDPRKRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKEPDLELEGLLKRHYTTVAFF 398
            |....::|||||||||.||||:|||||||:||:||:||:||||...|:||||.|.|||:|.|.|:
  Rat   402 SAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFY 466

  Fly   399 QGTMMNAVDLERVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNK 463
            ||:::|..||.|||:..|||||:||||||.|||||||:|||||||||||...||:|.|::|||||
  Rat   467 QGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNK 531

  Fly   464 AYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSF-KTSPDTQAWQNDYL 527
            |:|||||||:||:|||.|||||||||||||||||.|.|||:||||:|||| |...||  ||..||
  Rat   532 AHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDT--WQKYYL 594

  Fly   528 QGTGCEMYTETLSPSFTGMTFPQASELCFSKLKLLLLAIEIKGA--EEGADSKISINP-RGAKIQ 589
            :|...|||||.||.:|.|::||...||||.|||||::|||.|.|  |..:..:|.||| ...|||
  Rat   595 EGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQ 659

  Fly   590 ANTQGFFIAQSADEVKRAWFYCKACHEDIKDETLIKKCKCKNYVGMIMMQTGMVNQGITSVMNTM 654
            ..|.|||||..|.|||||:|||||||:|:.|...||||.|:.
  Rat   660 EGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRR----------------------- 701

  Fly   655 EDEHHPAPTFTPPELPKRVHVRGSVSGDITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAA 719
                        |::.....:..:...|..|...|.:.::..||         |.:..:......
  Rat   702 ------------PKMSIYKRMSRACCFDCGRSERDCSCMSGRVR---------GNVDTLERNFPL 745

  Fly   720 AAAAAAAGKQVNKVKPTVNVSRQVEGQVISPSQYNRPPENDANPYAGYQLAYEVKKLMPTSRSSG 784
            ::.:      ||....:.......:...:||.:..|......:|....:|......|:|
  Rat   746 SSVS------VNDCSTSFRAFEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIP------ 798

  Fly   785 TGTQNQNGGVSLPAGIADDQSKDFDFEKTEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGH 849
                            .:||..:.|  ....||||||||||...|.:|..||.|::||||||:||
  Rat   799 ----------------GNDQIDNMD--SNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGH 845

  Fly   850 VVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSP 914
            ||||:|.|..|.|||||||||||||||||||||||:|.|||::|::|||:.|.|.||:|:|.|:|
  Rat   846 VVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTP 910

  Fly   915 LSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFD- 978
            ||||||||||:||||||.||||...:.||.:|.|||.||||||||:|.|||:||||......|.
  Rat   911 LSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTP 975

  Fly   979 ---NLSATAGSPI--VLQRRGSVYGANVP---------------------------MITELVNDS 1011
               :.|:...||:  :|::.....|.|:|                           ||||||||:
  Rat   976 PGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDT 1040

  Fly  1012 NVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELEL 1076
            |||||||||||||||||||||||||||||||||||||||.||||.|.|||||:|:|||||||||.
  Rat  1041 NVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA 1105

  Fly  1077 ILAEGAGLRGGYSTVESLSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYR 1141
            ::||...|||||||.::|:|||||||.|::|.|||.|..|:.|.|||||..|||:|.|||.|:||
  Rat  1106 LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYR 1170

  Fly  1142 FRD----TSSSCDASSKRYVITNPPDDFSLLPTDQVFVLMQFD 1180
            .||    |.|.|   :|||||||||.:|.|:|||.:|.|||||
  Rat  1171 LRDAHLSTPSQC---TKRYVITNPPYEFELVPTDLIFCLMQFD 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slo	NP_001262924.1	Ion_trans	110..321	CDD:459842	139/211 (66%)
		TrkA	261..>504	CDD:440335	169/243 (70%)
		BK_channel_a	478..566	CDD:460947	59/88 (67%)
Kcnma1	XP_063130769.1	None