Protein Alignment slo and Kcnu1

DIOPT Version :9

• Sequence 1: NP_001262924.1
• Gene: slo / 42940
• FlyBaseID: FBgn0003429
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_017455870.1
• Gene: Kcnu1 / 680912
• RGDID: 1585877
• Length: 1123
• Species: Rattus norvegicus
• Alignment Length: 1206
• Identity: 449/1206 - (37%)
• Similarity: 638/1206 - (52%)
• Gaps: 188/1206 - (15%)

  Fly    35 FLLSSIFTFLAGLLVVLLWRAFAFVCCRKEPDLGPN------DPKQKEQKASRNKQEFEGTFMTE 93
            |:|||:.||..||:|:.::|....:....:...||.      ..::.|....| |..|.|.|
  Rat    27 FILSSLATFFGGLIVLFIFRIALKISRNWKTVKGPRGILELFSSRRIEVNPLR-KLYFHGVF--- 87

  Fly    94 AKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAFNIFF 158
             ::....|:|.||..|::||:|||:|||.||:|||:: |.:.|.:|..:.:.|. .:||:||.||
  Rat    88 -RERIEMLLSAQTIVGQVLVILVFVLSIGSLVIYFIN-SMDPVRKCSSYEDKIV-HVDLSFNAFF 149

  Fly   159 MVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLN 223
            ..||.:||.||.||:.|.|||.|.||.|||||:|:|.||...|:||||||||||:.:|.|||.|.
  Rat   150 SFYFGLRFWAAEDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPKILQILQ 214

  Fly   224 VLKTSSSIRLAQLVSIFISVWLTAAGIIHL----------LENSGDP-LDFNNAHRLSYWTCVYF 277
            |:|||:|::|::|:||.||.|.||||.:||          :|||||| |:..|:..:||:..:|.
  Rat   215 VIKTSNSVKLSKLMSIVISTWFTAAGFLHLTFPLPSLFGQVENSGDPWLNGRNSQTMSYFESIYL 279

  Fly   278 LIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAVFASWIPEITELAAQRSKYGGTYSKDPRKRHI 342
            :..||||||:|||..:|.|||.|:|||.|..|.:||::|||:.||.:.|.||...|.....|:.|
  Rat   280 VTATMSTVGFGDVVAKTSLGRIFIVFFTLGSLILFANYIPEMVELFSTRKKYNKPYEAVKGKKFI 344

  Fly   343 VVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKEPDLELEGLLKRHYTTVAFFQGTMMNAVD 407
            ||||:||.:||:.||::|||....::::|:|||....|.:|||.|||.|.:...|..||.:...|
  Rat   345 VVCGNITIDSVTAFLRNFLHRKAGEINIEIVFLGEAPPSVELETLLKCHTSCTTFVCGTALKFED 409

  Fly   408 LERVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSW 472
            |:||.|..|:|||:|||.:|.|...||.:|||||:|||||....|||||::|..||.:|..||:|
  Rat   410 LKRVAVENAEACLILANPFCSDLHDEDNSNIMRVLSIKNYYPQTRVIIQMLQSQNKVFLSRIPNW 474

  Fly   473 DWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPDTQAWQNDYLQGTGCEMYTE 537
            :|..||::||.||||||||||.||.||..|.:..||..::.|..| ...||..:|.|...::.|:
  Rat   475 NWSAGDNIICFAELKLGFIAQGCLVPGLCTFLTTLFIEQNQKVFP-KHPWQKHFLNGLKNKILTQ 538

  Fly   538 TLSPSFTGMTFPQASELCFSKLKLLLLAIEIKGAEEGADSKISINPRG-AKIQANTQGFFIAQSA 601
            .||..|.||||||.|.|||.|:.|:|:||:.|.......|.| :||.. .::..:|.|||||:|:
  Rat   539 RLSNDFVGMTFPQVSRLCFLKMHLMLIAIQHKPLFHNCCSLI-LNPSSQVRLNKDTLGFFIAESS 602

  Fly   602 DEVKRAWFYCKACHEDIKDETLIKKCKCKNYVGMIMMQTGMVNQGITSVMNTMEDEHHPAPTFTP 666
            .:||||.|||..||.|:.:..||.||.|||
  Rat   603 KDVKRALFYCSNCHSDVCNPELIGKCGCKN----------------------------------- 632

  Fly   667 PELPKRVHVRGSVSGDITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVN 731
                              |.|:..
  Rat   633 ------------------RSRQQL----------------------------------------- 638

  Fly   732 KVKPTVNVSRQVEGQVISPSQYNRPPENDANPYAGYQLAYEVKKLMPTSRSSGTGTQNQNGGV-- 794
             |.||:.|.                 ::..|.:|            ||:....:.::.|...|
  Rat   639 -VAPTIMVM-----------------QSSLNEFA------------PTAEIYTSISREQTSSVTI 673

  Fly   795 ----SLPAGIADDQSKDFDFEKTEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLF 855
                ::|...|||..          ..||:|||||..:..|:..:|.|:..|......|:|.|:|
  Rat   674 LTTRNMPVDTADDSD----------MLDSSGMFHWCRSMPLDKVVLKRSDKATHEFQNHIVACVF 728

  Fly   856 ADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADL 920
            .|..|.|:||||.||||||||:...|||.:|.:||::|.:|||:.|:|.|||.::.||.|...||
  Rat   729 GDAHSSLMGLRNFVMPLRASNYTRQELKDIVFIGSLEYFQREWRFLRNFPKIHIMPGSALYTGDL 793

  Fly   921 RAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFDNLSATAG 985
            .||||..|.||.||:....:.....|.|.|.|:|:|||:|:.....:...|::  |.:.
  Rat   794 HAVNVEQCSMCVILATPYKALSSQLLVDTETIMATLNIQALRISCPMSGSSKK--EVNT------ 850

  Fly   986 SPIVLQRRGSVYGANVPMITELVNDSNVQFLDQDDDDD---PDTELYLTQPFACGTAFAVSVLDS 1047
            ||...:..|......:|::|||.|.||:.|::|.|..|   ..|.|:|:..|:.||.|:.:.|||
  Rat   851 SPTFSKYEGKQRYQQIPILTELKNPSNIHFIEQMDGLDEAIKGTSLHLSTAFSTGTVFSGTFLDS 915

  Fly  1048 LMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVESLSNRDRCRVGQISLYDGPL 1112
            |::|.::|.:.|.|::.|:|||...:.|..|.:.....|.......||.|.||::|.:||.:..|
  Rat   916 LLATAFYNYHVLELLQMLVTGGINSQTEHCLVKEKLYEGNEGGATFLSGRTRCKLGLLSLDETIL 980

  Fly  1113 AQFGECGKYGDLFVAALKSYGMLCIGLYRFRDTSSSCDASSKRYVITNPPDDFSLLPTDQVFVLM 1177
            :.......:|.||..:|.:.|:||:||||..|.... ::..||:|||.|.::..|||:|.||..:
  Rat   981 SDIKPKKTFGQLFCGSLDNLGILCVGLYRMMDEGEH-NSERKRFVITRPANECHLLPSDLVFCAI 1044

  Fly  1178 QF---------DPGLEYKPPAVRAPAGGRGTNTQGS 1204
            .|         :..::.:.......:..:|:|.||:
  Rat  1045 PFSITCDKSESNASIQDQDTTTNVTSMSQGSNFQGA 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slo	NP_001262924.1	Ion_trans	110..321	CDD:395416	116/221 (52%)
		BK_channel_a	470..566	CDD:397526	47/95 (49%)
Kcnu1	XP_017455870.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1420
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53496
OrthoDB	1	1.010	-	-		D41052at33208
OrthoFinder	1	1.000	-	-		FOG0003516
OrthoInspector	1	1.000	-	-		otm45069
orthoMCL	1	0.900	-	-		OOG6_101271
Panther	1	1.100	-	-	O	PTHR10027
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.790