Protein Alignment slo and KCNMA1

DIOPT Version :9

• Sequence 1: NP_001262924.1
• Gene: slo / 42940
• FlyBaseID: FBgn0003429
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_016871696.1
• Gene: KCNMA1 / 3778
• HGNCID: 6284
• Length: 1311
• Species: Homo sapiens
• Alignment Length: 1250
• Identity: 656/1250 - (52%)
• Similarity: 804/1250 - (64%)
• Gaps: 179/1250 - (14%)

  Fly    30 RKYWCFLLSSIFTFLAGLLVVLLWRAFAF---VCCR-------KEP-----------DLGPNDPK 73
            |.:|.||.||:.||..||.::||||...:   |||.       ::|           .|.|.:.:
Human    85 RMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKGRKPRLQGGVIGCMFHLQPREAQ 149

  Fly    74 --------------------QKEQKASRNKQEFEGT----------------FMTEAKDWAGELI 102
                                ::.||.:....:.:||                :||..|||||.:|
Human   150 KSSSALEVHKKYGDSTGTTLEEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMI 214

  Fly   103 SGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRFI 167
            |.||.|||:||||||.|||.:|:|||:| ||..:|.||.:..:.|.|||:|||:||::||.:|||
Human   215 SAQTLTGRVLVVLVFALSIGALVIYFID-SSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFI 278

  Fly   168 AASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSIR 232
            ||:|||||.||:.|.||:||:||.|||:||:|:|:||||||||||:...:|||:||:||||:||:
Human   279 AANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIK 343

  Fly   233 LAQLVSIFISVWLTAAGIIHLLENSGDPLD-FNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVL 296
            |..|:|||||.||||||.|||:||||||.: |.|...|:||.|||.|:||||||||||||.:|.|
Human   344 LVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTL 408

  Fly   297 GRTFLVFFLLVGLAVFASWIPEITELAAQRSKYGGTYSKDPRKRHIVVCGHITYESVSHFLKDFL 361
            ||.|:|||:|.|||:|||::|||.||...|.||||:||....::|||||||||.||||:||||||
Human   409 GRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFL 473

  Fly   362 HEDREDVDVEVVFLHRKEPDLELEGLLKRHYTTVAFFQGTMMNAVDLERVKVHEADACLVLANKY 426
            |:||:||:||:||||...|:||||.|.|||:|.|.|:||:::|..||.|||:..|||||:|||||
Human   474 HKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKY 538

  Fly   427 CQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFI 491
            |.|||||||:|||||||||||...||:|.|::||||||:|||||||:||:|||.|||||||||||
Human   539 CADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFI 603

  Fly   492 AQSCLAPGFSTMMANLFAMRSF-KTSPDTQAWQNDYLQGTGCEMYTETLSPSFTGMTFPQASELC 555
            ||||||.|.|||:||||:|||| |...||  ||..||:|...|||||.||.:|.|::||...|||
Human   604 AQSCLAQGLSTMLANLFSMRSFIKIEEDT--WQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELC 666

  Fly   556 FSKLKLLLLAIEIKGA--EEGADSKISINP-RGAKIQANTQGFFIAQSADEVKRAWFYCKACHED 617
            |.|||||::|||.|.|  |..:..:|.||| ...|||..|.|||||..|.|||||:|||||||:|
Human   667 FVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDD 731

  Fly   618 IKDETLIKKCKCKNYVGMIMMQTGMVNQGITSVMNTMEDEHHPAPTFTPPELPKRVHVRGSVSGD 682
            |.|...||||.||.                                   |::.....:|.:...|
Human   732 ITDPKRIKKCGCKR-----------------------------------PKMSIYKRMRRACCFD 761

  Fly   683 ITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQV 747
            ..|...|.:.::..||               .|......|...:...||....:.......:...
Human   762 CGRSERDCSCMSGRVR---------------GNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPST 811

  Fly   748 ISPSQYNRPPENDANPYAGYQLAYEVKKLMPTSRSSGTGTQNQNGGVSLPAGIADDQSKDFDFEK 812
            :||.:..|......:|....:|......|:|                      .:||..:.|  .
Human   812 LSPKKKQRNGGMRNSPNTSPKLMRHDPLLIP----------------------GNDQIDNMD--S 852

  Fly   813 TEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNF 877
            ...||||||||||...|.:|..||.|::||||||:||||||:|.|..|.||||||||||||||||
Human   853 NVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNF 917

  Fly   878 HYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSND 942
            |||||||:|.|||::|::|||:.|.|.||:|:|.|:|||||||||||:||||||.||||...:.|
Human   918 HYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNID 982

  Fly   943 DPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFD----NLSATAGSPI--VLQRRGSVYGANV 1001
            |.:|.|||.||||||||:|.|||:||||......|.    :.|:...||:  :|::.....|.|:
Human   983 DTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNI 1047

  Fly  1002 P---------------------------MITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTA 1039
            |                           ||||||||:||||||||||||||||||||||||||||
Human  1048 PIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA 1112

  Fly  1040 FAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVESLSNRDRCRVGQ 1104
            |||||||||||.||||.|.|||||:|:|||||||||.::||...|||||||.::|:|||||||.|
Human  1113 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQ 1177

  Fly  1105 ISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFRD----TSSSCDASSKRYVITNPPDDF 1165
            ::|.|||.|..|:.|.|||||..|||:|.|||.|:||.||    |.|.|   :|||||||||.:|
Human  1178 LALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQC---TKRYVITNPPYEF 1239

  Fly  1166 SLLPTDQVFVLMQFD 1180
            .|:|||.:|.|||||
Human  1240 ELVPTDLIFCLMQFD 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slo	NP_001262924.1	Ion_trans	110..321	CDD:395416	139/211 (66%)
		BK_channel_a	470..566	CDD:397526	65/96 (68%)
KCNMA1	XP_016871696.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	551	1.000	Domainoid score	I249
eggNOG	1	0.900	-	-		E1_KOG1420
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1693
Inparanoid	1	1.050	1237	1.000	Inparanoid score	I185
Isobase	1	0.950	-	0	Normalized mean entropy	S2986
OMA	1	1.010	-	-		QHG53496
OrthoDB	1	1.010	-	-		D124461at2759
OrthoFinder	1	1.000	-	-		FOG0003516
OrthoInspector	1	1.000	-	-		oto89356
orthoMCL	1	0.900	-	-		OOG6_101271
Panther	1	1.100	-	-	LDO	PTHR10027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790