Protein Alignment slo and slo-1

DIOPT Version :9

• Sequence 1: NP_001262924.1
• Gene: slo / 42940
• FlyBaseID: FBgn0003429
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001256802.1
• Gene: slo-1 / 180203
• WormBaseID: WBGene00004830
• Length: 1160
• Species: Caenorhabditis elegans
• Alignment Length: 1206
• Identity: 743/1206 - (61%)
• Similarity: 877/1206 - (72%)
• Gaps: 133/1206 - (11%)

  Fly    26 CLKVRKYWCFLLSSIFTFLAGLLVVLLWRAFAFVCCRK------EPDLGP--------------- 69
            ||:.|||||||||||.||.|.:::|::||....:||::      ||...|
 Worm    39 CLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPS 103

  Fly    70 -NDP--KQKEQKASRNKQEFEGTFMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDA 131
             .||  ||:|:|        ...:|||||||||||||||:.|||.||:|||||||.||||||.||
 Worm   104 ETDPFLKQQEEK--------HLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDA 160

  Fly   132 SSE--EVERCQKWSNNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVS 194
            |.:  :||.|..|.::.:|||||.|||||:|||||||||||||:||:|||||::|:||||||||:
 Worm   161 SFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVA 225

  Fly   195 IYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGD 259
            |||.|.|:|.|||||||||||||||||||:|||||||||.|||:||::|.||.||::||||||||
 Worm   226 IYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGD 290

  Fly   260 PL-DFNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAVFASWIPEITELA 323
            .. .|.|.||::|...|||::||||||||||:||.|:.||.|::||:|.|||:|||::|||.:|.
 Worm   291 FFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLI 355

  Fly   324 AQRSKYGGTYSKDPRKRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKEPDLELEGLL 388
            ..|.||||.|..:..|:||||||||||:||||||:|||||||:|||||||||||..||||||||.
 Worm   356 GNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLF 420

  Fly   389 KRHYTTVAFFQGTMMNAVDLERVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRV 453
            |||:|.|.||.||:|:::||.|||:.:|||||||||||..:|||||||||||||||||||.||||
 Worm   421 KRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRV 485

  Fly   454 IIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPD 518
            |:||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||.
 Worm   486 IVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPH 550

  Fly   519 TQAWQNDYLQGTGCEMYTETLSPSFTGMTFPQASELCFSKLKLLLLAIEIKGAEEGADSKISINP 583
            |..|.||||:|.|.|||||:|||||..|:||:|:.|.|::|.|||||||:|. ||..:..|:|||
 Worm   551 TPLWLNDYLRGAGMEMYTESLSPSFANMSFPEAANLLFNRLGLLLLAIELKD-EENKECNIAINP 614

  Fly   584 RGAK--IQANTQGFFIAQSADEVKRAWFYCKACHEDIKDETLIKKCKCKNYVGMIMMQTGMVNQG 646
             |..  ||..||||||||||||||||:|:||.||:||||.:|||||||||..
 Worm   615 -GPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLA------------- 665

  Fly   647 ITSVMNTMEDEHHPAPTFTPPELPKRVHVRGSVSGDITRDREDTNLLNRNVRRPNGTGNGTG--- 708
                                                         |..||.:..........
 Worm   666 ---------------------------------------------LFRRNTKHSTAAREKNAKIS 685

  Fly   709 ------GMHHMNNTAAAAA-----AAAAAGKQVNKVKPTVNVSRQVEGQVISPSQYNRPPENDAN 762
                  .:.:.|:..|...     ..|.||       |..::.:||:.::|  :|.:...:...|
 Worm   686 DYSDFDALFYQNDARATDVLQQFQPQAPAG-------PMGHLGQQVQLRMI--NQQSSTSDTHLN 741

  Fly   763 PYAGYQLAYEVKKLMPTSRSSGTGTQNQNGGVSLPA-GIADDQSKDFDFEKTEMKYDSTGMFHWS 826
            . ...:.|||:|||||   ||| |.:|   .:|:|. |...|.||||:.:..:|||||||||||.
 Worm   742 T-KSLRFAYEIKKLMP---SSG-GRRN---SMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWC 798

  Fly   827 PAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSV 891
            |:::||||:|:|:||||||||||||||||||.|||||||||.:||||:|||||||||||||||.:
 Worm   799 PSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDL 863

  Fly   892 DYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASL 956
            :|:|:|||.|.||||||:|||||||||||||||:||||||.|:||:||:.:|.||||||||||||
 Worm   864 EYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASL 928

  Fly   957 NIKAMTFDDTIGVLSQRGPEFDNLSATAGSPIVLQRRGSVYGANVPMITELVNDSNVQFLDQDDD 1021
            |||||.||||:|....|....|.  :..||||.:|::|:.:|.||||||||||||||||||||||
 Worm   929 NIKAMQFDDTLGFFPMRHQTGDR--SPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDD 991

  Fly  1022 DDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRG 1086
            ||||||||||||||||||||:|||||||||||||.:||||||:|:||||||||||||||||||||
 Worm   992 DDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRG 1056

  Fly  1087 GYSTVESLSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFRDTSSSCDA 1151
            ||||.|:||||||||:.||||.|.|.........||.:|..||:.||.|||||||..|..:  ..
 Worm  1057 GYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDN--PD 1119

  Fly  1152 SSKRYVITNPPDDFSLLPTDQVFVLMQFDPGLEYKP 1187
            |.|||||||||.:..:..||.|:||.||||||||:|
 Worm  1120 SMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEP 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slo	NP_001262924.1	Ion_trans	110..321	CDD:395416	150/213 (70%)
		BK_channel_a	470..566	CDD:397526	76/95 (80%)
slo-1	NP_001256802.1	Ion_trans	139..360	CDD:366146	152/220 (69%)
		BK_channel_a	509..584	CDD:367524	62/74 (84%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164763
Domainoid	1	1.000	624	1.000	Domainoid score	I85
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1693
Inparanoid	1	1.050	1398	1.000	Inparanoid score	I56
Isobase	1	0.950	-	0	Normalized mean entropy	S2986
OMA	1	1.010	-	-		QHG53496
OrthoDB	1	1.010	-	-		D124461at2759
OrthoFinder	1	1.000	-	-		FOG0003516
OrthoInspector	1	1.000	-	-		oto19184
orthoMCL	1	0.900	-	-		OOG6_101271
Panther	1	1.100	-	-	LDO	PTHR10027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8765
SonicParanoid	1	1.000	-	-		X5164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890