Protein Alignment slo and kcnt1a

DIOPT Version :10

• Sequence 1: NP_001262924.1
• Gene: slo / 42940
• FlyBaseID: FBgn0003429
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_068072065.2
• Gene: kcnt1a / 100004419
• ZFINID: ZDB-GENE-091231-1
• Length: 1231
• Species: Danio rerio
• Alignment Length: 1162
• Identity: 245/1162 - (21%)
• Similarity: 438/1162 - (37%)
• Gaps: 321/1162 - (27%)

  Fly    87 EGTFMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQID 151
            |.||....|.:   .|..|.::.||. :..|.|.:.:.::|.:...::...:.:....|.:.|.|
Zfish    97 ENTFKERLKLF---FIKNQRSSLRIR-IFNFCLKLLTCVLYIIRVMTDNPAQLRHTCVNCSSQND 157

  Fly   152 LAFNIFFMV-----YFFIRFIAAS---------------DKLW-------FMLEMYSFVDY-FTI 188
            :.:.:.|.|     .:.|:.|.||               ..||       |:|||.:.|.: .||
Zfish   158 INWELIFWVDRKVPVWAIQVIVASISFMEAMLLTYLSYKGNLWEQIFQVSFLLEMLNTVPFIITI 222

  Fly   189 --PP---SFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSI---RLAQLVSIFISVWL 245
              ||   .|:.::|: .|:....|.::    :.|:  :..:.:|.|::   .|..:.::...|:.
Zfish   223 FWPPLRNLFIPVFLN-CWLAKCALESM----INDL--HRAIQRTHSAMFNQVLILICTLLCLVFT 280

  Fly   246 TAAGIIHLLENSGDPLDFNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLA 310
            ...||.| ||.:|       ...||.:..:||.|||.||||:|||..:....:..:|..:.|.|.
Zfish   281 GTCGIQH-LERAG-------KKSLSLFNALYFCIVTFSTVGFGDVTPQIWPSQLLVVVMICVALV 337

  Fly   311 VFASWIPEITELAAQRSKYGGTYSKD--PRKRHIVVCGHITYESVS----HFLKDFLHE---DRE 366
            |......|:..|..:|.|.||.||:.  ..:||:|:|       ||    ..|.|||:|   ...
Zfish   338 VLPLQFEELIYLWMERQKSGGNYSRHRAQTERHVVLC-------VSTLKIDLLMDFLNEFYAHPH 395

  Fly   367 DVDVEVVFLHRKEPDLELEGLLKRHYTT--VAFFQGTMMNAVDLERVKVHEADACLVLANKYCQD 429
            ..|..||.|...|.|:::..:|:....:  |.:.||:.:...||.|.|:.:|:||.:|:::...|
Zfish   396 TQDYYVVILCPCEVDVQVRRILQIPLWSQRVIYLQGSALKNQDLLRAKMDDAEACFILSSRNEAD 460

  Fly   430 PDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQS 494
            ..|.|...|:|..::|:::.:..:.:|:::..||.::        |..|.|:|..|.|...:|.:
Zfish   461 RMAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHV--------KFADHVVCEEEFKYAMLALN 517

  Fly   495 CLAPGFSTMMANL-FAMRSFKTSPDTQAWQNDYLQGTGCEMYTETLSPS-----FTGMTFPQASE 553
            ||.|..||::..| ...|..:.....:.||..|.:.:|.|:|...|..|     :...:|..|:.
Zfish   518 CLCPATSTLITLLVHTSRGQEGQQSPEQWQRMYGRCSGNEVYHIRLGDSMFFREYNSKSFTYAAF 582

  Fly   554 LCFSKLKLLLLAIEIKGAEEGADSKISINPRGAKIQANTQGFFIAQSADEVKRAWFYCKACHEDI 618
            ....|..:.::     |.:...:..|.:||....|.:.:...:......|...|:.:.:..::.
Zfish   583 HAHKKYGVCMI-----GVKREDNKSILLNPGPRHIMSASDTCYYINITKEENSAFIFRQEENQG- 641

  Fly   619 KDETLIKKCKCKNYVGMIMMQTGMVNQGITSVMNTME-DEHHPAPTFTPPEL-PKRVHVRGSVSG 681
                     |.:::..::...:|:....|.:.|.|:. |..:.:||.:..:| |...:..||
Zfish   642 ---------KGRSHCDILNSPSGLPVHSIIASMGTVAMDFQNTSPTESRLKLAPPTENELGS--- 694

  Fly   682 DITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQ 746
                            |||:                               :.|.:.::
Zfish   695 ----------------RRPS-------------------------------IAPVLEIA------ 706

  Fly   747 VISPSQYNRPPENDANPYAGYQLAYEVKKLMPTSRSSGTGTQNQNGGVSLPAGIADDQSKDFDFE 811
                                     :...|:|....|   .|:::     .||.:|:.....||.
Zfish   707 -------------------------DSASLLPCDLLS---DQSED-----EAGHSDEDITATDFV 738

  Fly   812 K---TEMKY--DSTGMFHWSPAKSLEDCI-LDR--------NQAAMTVLNGHVVVCLFADPDSPL 862
            |   ....|  .|..:.|..|.|:...|: ||:        :..|....|..::|    ..::..
Zfish   739 KGYPPNSPYIGSSPTLCHLLPQKAPFCCLRLDQSCEHVSFEDAKAYGFKNKLIIV----SAETAG 799

  Fly   863 IGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPK---ISVLNGSPL-----SRAD 919
            .||.|.::||||......||..:|:            :|.|||.   :..::..|:     ...|
Zfish   800 NGLYNFIVPLRAYYRPRRELNPIVL------------LLDNLPDDHFLEAISCFPMVYYMGGTID 852

  Fly   920 LRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFDNLSATA 984
                |::....|.:|.|     |:..:.|||:.:::                    |.|.: |.|
Zfish   853 ----NLDSLLQCGVLYA-----DNLVVVDKESTMSA--------------------EEDYM-ADA 887

  Fly   985 GSPIVLQRRGSVYGANVPMITELVNDSNVQFL----------------------------DQDDD 1021
            .:.:.:|....:: .::.:||||.:.||::|:                            ||..:
Zfish   888 KTIVNVQTMFRLF-PSLSIITELTHPSNMRFMQFRAKDCYSLALSKLEKFCNWNIAKCVFDQQKE 951

  Fly  1022 DDPDTEL--YLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGL 1084
            .|..:.|  ....|||.|..|::|:||:|:...:.....:.:.|.|:....||
Zfish   952 RDKGSNLAFMFRLPFAAGRVFSISMLDTLLYQCFVKDYMIPIARLLLGLDTTP------------ 1004

  Fly  1085 RGGYSTVESLSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYR 1141
            ..||.....:...|        |:         ...||.||.....|...:.||:||
Zfish  1005 GSGYLCAMHICEAD--------LW---------IRTYGRLFQKFCSSSSEIPIGIYR 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slo	NP_001262924.1	Ion_trans	110..321	CDD:459842	59/246 (24%)
		TrkA	261..>504	CDD:440335	76/253 (30%)
		BK_channel_a	478..566	CDD:460947	24/93 (26%)
kcnt1a	XP_068072065.2	None