DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K10 and KIN4

DIOPT Version :9

Sequence 1:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens
Sequence 2:	NP_014876.1	Gene:	KIN4 / 854408	SGDID:	S000005759	Length:	800	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	198/986 - (20%)
Similarity:	331/986 - (33%)	Gaps:	343/986 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    87 LQLPQEI--PFHELQ----------LEEIIGVGGFGKVYRALWR--------GEEVAVKAARLDP 131
            ||...||  |.|:.|          :...:|.|.|||| :..|.        .::||:|..|.|.
Yeast    23 LQRNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKV-KLGWTKASSSNEVPKQVAIKLIRRDT 86

Human   132 EKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSR-VLAGRRVPPHV 195
            .|..|....::.:|......|.|||||.|.....|..::.:|:|:..||...: :...||:....
Yeast    87 IKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESS 151

Human   196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK 260
            ......|:..|:||:|...   ::|||||..| |:|:..||       |.|||||...|:.:..:
Yeast   152 ACRLFAQLISGVNYMHYKG---LVHRDLKLEN-LLLDKHEN-------LVITDFGFVNEFFEDNE 205

Human   261 M--SAAGTYAWMAPEVI--RLSLFSKSSDVWSFGVLLWELLTGEVPYREI------DALAVAYGV 315
            :  ::.|:..:.|||::  ..:..::.:||||.||:|:.:|.|.:|:.:.      |.:|..|
Yeast   206 LMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLY-- 268

Human   316 AMNKLTLPIPSTCPEPFARLLEGEPGPRD--EECWDPDPHGRPDFGSILKRLEVIEQSALFQMPL 378
               |.....|...||...      |.|||  .....|:|..|.:..:|.:.        ::..|.
Yeast   269 ---KYITQTPLKFPEYIT------PIPRDLLRRILVPNPRRRINLQTIKRH--------VWLKPH 316

Human   379 ESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVE 443
            |:|.|:|.::       :|:
Yeast   317 EAFLSIQPNY-------WDE--------------------------------------------- 329

Human   444 RELHLLMCQLSQEKPRVRKRKGNFKR--------SRLLKLREGGSHISLPSGFEHKITVQASPTL 500
                    .|.:|:|: ...||:..|        |...|.|:..|.|...:..:|::    ||.|
Yeast   330 --------HLQKERPK-PPNKGDVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHRM----SPQL 381

Human   501 DKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGR 565
                   ..|.||||:.                 |:||....:.|.:    ..||..:.|:   |
Yeast   382 -------ATSRPASPTF-----------------STGSKVVLNDTKN----DMKESNINGE---R 415

Human   566 TWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGG 630
            |.......:..:..|:.:::.:         ||.:..:..|||.:|                 |.
Yeast   416 TSASCRYTRDSKGNGQTQIEQV---------SARHSSRGNKHTSVA-----------------GL 454

Human   631 SSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGL 695
            .::|.||.:                ||     |.:||.::                        |
Yeast   455 VTIPGSPTT----------------AR-----TRNAPSSK------------------------L 474

Human   696 GADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLG------------- 747
            ...|.::......::.       |.|.|.:.   .|.:||  |.....|||.
Yeast   475 TEHVKDSSQTSFTQEE-------FHRIGNYH---VPRSRP--RPTSYYPGLSRNTADNSLADIPV 527

Human   748 --------LAPSATLVSLSSVSDCN----STRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTN 800
                    |..:...|.|:::.|.|    |..|::....   .|||.:.|..........:....
Yeast   528 NKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLLSE---GPAAKTSPVDYHYAIGDLNHGDK 589

Human   801 PLVDLELESFKKD----------PRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGP 855
            |:.:: ::...||          ||:|:.|...:...........|..|....|.   |..||..
Yeast   590 PITEV-IDKINKDLTHKAAENGFPRESIDPESTSTILVTKEPTNSTDEDHVESQL---ENVGHSS 650

Human   856 GPRDLLDFPRLPDPQALFPARR-------------------------RPPEFPGRPTTLTFAPRP 895
            ...|....   .|.:.::..:|                         .||.....|:..:.....
Yeast   651 NKSDASSD---KDSKKIYEKKRFSFMSLYSSLNGSRSTVESRTSKGNAPPVSSRNPSGQSNRSNI 712

Human   896 RPAASRPR------LDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLL----------DMDM 944
            :....:||      .:|.|.::..| :..:.||..:: |:|| .||:.:::          ::..
Yeast   713 KITQQQPRNLSDRVPNPDKKINDNR-IRDNAPSYAES-ENPG-RSVRASVMVSTLREENRSELSN 774

Human   945 EGQN---QDST 952
            ||.|   |.||
Yeast   775 EGNNVEAQTST 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		TyrKc	98..365	CDD:197581	81/297 (27%)
		PKc_like	103..368	CDD:304357	80/285 (28%)
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	80/299 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910