DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP3K10 and BCK1

DIOPT Version :9

Sequence 1:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	330	Identity:	88/330 - (26%)
Similarity:	153/330 - (46%)	Gaps:	53/330 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   102 EIIGVGGFGKVYRAL--WRGEEVAVKAARLD--PEKDPAV--TAEQVCQEARLFGALQHPNIIAL 160
            |:||.|.||.||..|  ..||.:|||...:.  ..::.|:  |.|.:..|......|.|.||:..
Yeast  1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQY 1243

Human   161 RGACLNPPHLCLVMEYARGGALSRVLA--GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDL 223
            .|.........|.:||..||::..::.  ||...| ::.:...||.:|:.|||:..   |:|||:
Yeast  1244 LGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEP-LIKHLTTQVLKGLAYLHSKG---ILHRDM 1304

Human   224 KSINILILEAIENHNLADTVLKITDFGLAR---EWHKTTKMSAAGTYAWMAPEVIRLSL-FSKSS 284
            |:.|:|:.:        |.:.||:|||::|   :.:..:.|:..||..|||||::.... :|...
Yeast  1305 KADNLLLDQ--------DGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKV 1361

Human   285 DVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIP-STCPEPFARLLEGEPGPRD--EE 346
            |:||.|.::.|:..|:.|:..::.:|..:.:..:|...||| .|.|      |..:.| |:  :.
Yeast  1362 DIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLP------LISQIG-RNFLDA 1419

Human   347 CWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEK----ELR 407
            |::.:|..||....:|.               ..|..:.|.:..:...:...:::.:|    :||
Yeast  1420 CFEINPEKRPTANELLS---------------HPFSEVNETFNFKSTRLAKFIKSNDKLNSSKLR 1469

Human   408 SREEE 412
            ...:|
Yeast  1470 ITSQE 1474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		TyrKc	98..365	CDD:197581	82/277 (30%)
		PKc_like	103..368	CDD:304357	81/279 (29%)
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	82/294 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910