Protein Alignment MAP3K10 and SLA1

DIOPT Version :10

• Sequence 1: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Sequence 2: NP_009546.1
• Gene: SLA1 / 852276
• SGDID: S000000103
• Length: 1244
• Species: Saccharomyces cerevisiae
• Alignment Length: 854
• Identity: 156/854 - (18%)
• Similarity: 254/854 - (29%)
• Gaps: 298/854 - (34%)

Human    23 AVFDYEAA--GDEELTLRRGDRVQVLSQDCAVSGDEGW-WTGQLPSGRVGVFPSNYV-------- 76
            |::|||..  .|||||....|...|....     |..| ......|...|..|.|||
Yeast    76 AIYDYEQVQNADEELTFHENDVFDVFDDK-----DADWLLVKSTVSNEFGFIPGNYVEPENGSTS 135

Human    77 ----APGAPAAPAGLQ---------LPQEI---PFHELQLEEIIGVGGFGKVYRALWRGEEVAVK 125
                ||.|..|||...         ||...   |.|..:.             |.:...|:.|
Yeast   136 KQEQAPAAAEAPAATPAAAPASAAVLPTNFLPPPQHNDRA-------------RMMQSKEDQA-- 185

Human   126 AARLDPEKD-----PAV-------------TAEQVCQEARL------------------------ 148
                 |::|     ||:             ||..|....||
Yeast   186 -----PDEDEEGPPPAMPARPTATTETTDATAAAVRSRTRLSYSDNDNDDEEDDYYYNSNSNNVG 245

Human   149 ---FGALQHP-NIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNY 209
               :....|. |:..:.|.......|.:      |......:..:..|....::..|.......:
Yeast   246 NHEYNTEYHSWNVTEIEGRKKKKAKLSI------GNNKINFIPQKGTPHEWSIDKLVSYDNEKKH 304

Human   210 LHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAG--TYAWMAP 272
            :..:...|....:|.:.|....|.|.| .:.:......|.|| ||....:|....|  .|.:||.
Yeast   305 MFLEFVDPYRSLELHTGNTTTCEEIMN-IIGEYKGASRDPGL-REVEMASKSKKRGIVQYDFMAE 367

Human   273 EVIRLSLFS----------KSSDVWSFGVLLWELL----TGEVPYREIDAL-------AVAYGV- 315
            ....|::.|          ||.|.|     :.:|:    :|.||.:.|:.:       :.|.|:
Yeast   368 SQDELTIKSGDKVYILDDKKSKDWW-----MCQLVDSGKSGLVPAQFIEPVRDKKHTESTASGII 427

Human   316 -AMNKLTLPIPSTCPEPFARLLEGEPGPRDEECWD--------------------PDPHGRPDFG 359
             ::.|.....||................:|:|..:                    .:.....||.
Yeast   428 KSIKKNFTKSPSRSRSRSRSKSNANASWKDDELQNDVVGSAAGKRSRKSSLSSHKKNSSATKDFP 492

Human   360 SILKRLEVIEQSALFQMPLE-------SFHSLQEDWKLEIQHMFDDLRTKE------------KE 405
            :..|....:::|..|::..|       ..| |.:...::|....|.|..::            ::
Yeast   493 NPKKSRLWVDRSGTFKVDAEFIGCAKGKIH-LHKANGVKIAVAADKLSNEDLAYVEKITGFSLEK 556

Human   406 LRSREEELLRAAQEQRFQEEQLRR-REQELAEREMDIVERELHLLMCQ---LSQEKPRVRKRK-- 464
            .::.:....|....:..:.|:.|| :|||..||:..:.||||:.|...   |.:|:.|:::::
Yeast   557 FKANDGSSSRGTDSRDSERERRRRLKEQEEKERDRRLKERELYELKKARELLDEERSRLQEKELP 621

Human   465 -------------------------------------------G-----------NFKRSRL--- 472
                                                       |           ||.|.:|
Yeast   622 PIKPPRPTSTTSVPNTTSVPPAESSNNNNSSNKYDWFEFFLNCGVDVSNCQRYTINFDREQLTED 686

Human   473 ------------LKLREGG-----SHISLPSGFEHKITVQASPTLDKRKGSDGA-----SPPAS- 514
                        |.||||.     .|:....|.|:..::..:.|.:.....||:     ||..|
Yeast   687 MMPDINNSMLRTLGLREGDIVRVMKHLDKKFGRENIASIPTNATGNMFSQPDGSLNVATSPETSL 751

Human   515 -PSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERV 578
             ..::|:    ..:|.....|:|..:   ...|:.....|.|..:..||...|......|.
Yeast   752 PQQLLPQ----TTSPAQTAPSTSAET---DDAWTVKPASKSESNLLSKKSEFTGSMQDLLD---- 805

Human   579 GGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSY 643
                 |:.|.......|:..|||                   ::....:.||::||.:|.|:...
Yeast   806 -----LQPLEPKKAAASTPEPNL-------------------KDLEPVKTGGTTVPAAPVSSAPV 846

Human   644 LSVPLPAEP 652
            .|.|.|.:|
Yeast   847 SSAPAPLDP 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	17/55 (31%)
		Protein Kinases, catalytic domain	103..368	CDD:473864	56/355 (16%)
SLA1	NP_009546.1	SH3_Sla1p_1	7..64	CDD:212707
		SH3	73..127	CDD:473055	17/55 (31%)
		SH3_Sla1p_3	356..412	CDD:212709	15/60 (25%)
		SHD1	489..554	CDD:427630	11/65 (17%)
		SAM_SLA1_fungal	655..716	CDD:188931	11/60 (18%)
		DUF5585	<723..1040	CDD:465521	33/168 (20%)
		Med15	967..>1230	CDD:312941