DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K10 and BOI1

DIOPT Version :9

Sequence 1:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens
Sequence 2:	NP_009468.1	Gene:	BOI1 / 852193	SGDID:	S000000181	Length:	980	Species:	Saccharomyces cerevisiae

Alignment Length:	894	Identity:	167/894 - (18%)
Similarity:	289/894 - (32%)	Gaps:	295/894 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    19 PVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGD--EGWWTGQ-LPSGRVGVFPSNYVAPGA 80
            |::.||..|....::||.::.||:::|::.|    |:  :||:.|: |.:...|::|:.:....|
Yeast    16 PLYIAVNQYSKRMEDELNMKPGDKIKVITDD----GEYNDGWYYGRNLRTKEEGLYPAVFTKRIA 76

Human    81 PAAPAGLQLPQEIPFHELQLEEIIGVG-----------GFGKVYRALWRGEEVAVKAARLDPEKD 134
            ...|..|        |:...:|....|           ..|||..........::|:...|.:|
Yeast    77 IEKPENL--------HKSPTQESGNSGVKYGNLNDSASNIGKVSSHQQENRYTSLKSTMSDIDK- 132

Human   135 PAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL--AGRRVPPHVLV 197
                                                  .:|..|.|::.:.:  :..|||
Yeast   133 --------------------------------------ALEELRSGSVEQEVSKSPTRVP----- 154

Human   198 NWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIEN--HNLADTVLKIT-DFGLAREWHKTT 259
                           :...|    .|:....||.|...|  :...|::...| |..|:.|..|..
Yeast   155 ---------------EVSTP----QLQDEQTLIQEKTRNEENTTHDSLFSSTADLNLSSESLKNI 200

Human   260 KMSAAGTYAWMAP--EVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTL 322
            ..|...|.: :.|  |.:| .|..|.:..||             |....|..::   |..::
Yeast   201 SKSNISTKS-LEPSSESVR-QLDLKMAKSWS-------------PEEVTDYFSL---VGFDQ--- 244

Human   323 PIPSTCPEPFARLLEGEPGPRDEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQED 387
               |||    .:..|.:..                 |.||..||:   ..|.::.:.||....:.
Yeast   245 ---STC----NKFKEHQVS-----------------GKILLELEL---EHLKELEINSFGIRFQI 282

Human   388 WKLEIQHMFDDLRTKEKEL---------RSREEELLRAAQEQRFQEEQ-----LRRREQELAERE 438
            :| ||:::...:.:...:|         .::..:|:.||...|.:.:|     ..:...|.::|:
Yeast   283 FK-EIRNIKSAIDSSSNKLDADYSTFAFENQAAQLMPAATVNRDEIQQQISSKCNKLSSESSDRK 346

Human   439 MDIVERELHLLMCQLSQEKPRVRKRKGNFK----RSRLLKLR------------EGGSHISLPSG 487
            ...|..||         ::|.......|||    ..::|.:.            |.......|..
Yeast   347 SSSVTTEL---------QRPSSVVVNPNFKLHDPAEQILDMTEVPNLFADKDIFESPGRAPKPPS 402

Human   488 FEHKITVQASPTLDKRKGSDGAS-------PPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGT 545
            :...:....||:.:.|..::.|.       ||.:.:  |.:.:..|.|     :||.||...:|.
Yeast   403 YPSPVQPPQSPSFNNRYTNNNARFPPQTTYPPKNKN--PTVYSNGLIP-----NSSTSSDNSTGK 460

Human   546 WSRGGPPKKEELVGGKKKGR-TWGPSSTLQK-ERVGGEERLKGLGEGSKQWSSSAPN----LGKS 604
            :      |...:.|.....| |...|:|:.. ..|..:|.|..:...|...:|..||    :..:
Yeast   461 F------KFPAMNGHDSNSRKTTLTSATIPSINTVNTDESLPAISNISSNATSHHPNRNSVVYNN 519

Human   605 PKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPA--------EPSPGARAPWE 661
            .|.|.....|..|                    ::..|.|| |:.:        :||..:||.::
Yeast   520 HKRTESGSSFVDL--------------------FNRISMLS-PVKSSFDEEETKQPSKASRAVFD 563

Human   662 PTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFP 726
                        .|||:            .:.|...|   |..::.::.||....|.|..:
Yeast   564 ------------SARRK------------SSYGHSRD---ASLSEMKKHRRNSSILSFFSS---- 597

Human   727 RGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAP 791
            :..|.|..|..:...:.|.     ..|..|.|..:..:..||...|.|.:.:...   .|...:.
Yeast   598 KSQSNPTSPTKQTFTIDPA-----KMTSHSRSQSNSYSHARSQSYSHSRKHSLVT---SPLKTSL 654

Human   792 TPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDG 840
            :|..|.|...|...|            |||......|||:     ||:|
Yeast   655 SPINSKSNIALAHSE------------TPTSSNNKEAVSQ-----PSEG 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	16/58 (28%)
		TyrKc	98..365	CDD:197581	45/284 (16%)
		PKc_like	103..368	CDD:304357	46/282 (16%)
BOI1	NP_009468.1	SH3_BOI	17..71	CDD:212819	16/57 (28%)
		SAM_superfamily	226..290	CDD:417767	20/110 (18%)
		PH_Boi	778..894	CDD:270126
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I3572
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000