Protein Alignment MAP3K10 and Src64B

DIOPT Version :10

• Sequence 1: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Sequence 2: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 123/475 - (25%)
• Similarity: 174/475 - (36%)
• Gaps: 160/475 - (33%)

Human    14 TTPAG-------PVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWW-TGQLPSGRVGV 70
            |||.|       .|..|::||::..:.:|:..:|||::|:...     :..|| ...|.:.:.|:
  Fly    86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDT-----ESDWWRVVNLTTRQEGL 145

Human    71 FPSNYVAPG-----------------------APAAPAGLQL----------------------- 89
            .|.|:||..                       |...|.|..|
  Fly   146 IPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRG 210

Human    90 ------------------------------------------------------PQ--------- 91
                                                                  ||
  Fly   211 YHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELR 275

Human    92 ---EIPFHELQLEEIIGVGGFGKVYRALWRGE-EVAVKAARLDPEKDPAVTAEQVCQEARLFGAL 152
               |||..|:||...:|.|.||:|:...||.. :||||..|     :..::.....|||.:....
  Fly   276 DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR-----EGTMSTAAFLQEAAIMKKF 335

Human   153 QHPNIIALRGACLNPPHLCLVMEYARGGALSRVLA---GRRVPPHVLVNWAVQVARGMNYLHNDA 214
            :|..::||...|.....:.:|.||...|:|...|.   ||.:....|:..|.|||.||.||.:.
  Fly   336 RHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESK- 399

Human   215 PVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWHKTTKMSAAGTYAWMAPEVIR 276
              .:|||||.:.|:||.|        :.|.||.||||||   :.....|..:.....|.|||.|.
  Fly   400 --QLIHRDLAARNVLIGE--------NNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAII 454

Human   277 LSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPST--CPEPFARLLEG 338
            ...||..|||||:|:||.||.| |:|||..:.:..|...:... ..:|.|:.  .|:...:||
  Fly   455 YGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERG-FRMPKPTNHYFPDNIYQLL-- 516

Human   339 EPGPRDEECWDPDPHGRPDF 358
                  .:|||..|..||.|
  Fly   517 ------LQCWDAVPEKRPTF 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	15/56 (27%)
		Protein Kinases, catalytic domain	103..368	CDD:473864	90/266 (34%)
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	4/100 (4%)
		PTKc_Src_like	289..538	CDD:270630	90/267 (34%)
		SH3_Src_like	99..150	CDD:212779	14/55 (25%)