DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K10 and slpr

DIOPT Version :9

Sequence 1:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	1082	Identity:	382/1082 - (35%)
Similarity:	484/1082 - (44%)	Gaps:	283/1082 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    18 GPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPA 82
            |.:|||::||:|.|::|||||||:.|.|||.|..||||.|||||:: ..:|||||.::|....|
  Fly    45 GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKI-GDKVGVFPKDFVTDEDP- 107

Human    83 APAGLQL----------PQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAV 137
                |||          |.||.::||.::|:||.|||.||:|..:.|||||:|.|....|.|...
  Fly   108 ----LQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQR 168

Human   138 TAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQ 202
            ..:.|.|||:||.||:|.||.||||.||| ..|||||||||||:|:|:||| ::||.||||||:|
  Fly   169 MRDNVLQEAKLFWALKHENIAALRGVCLN-TKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQ 231

Human   203 VARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTY 267
            :|||||||||:||:.||||||||.|:||.||||.::|....|||||||||||.:.|.:|||||||
  Fly   232 IARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTY 296

Human   268 AWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPF 332
            |||.||||.:|.:||.|||||:|||||||:|||.||:..|.|:||||||:|.||||||.||||.:
  Fly   297 AWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETW 361

Human   333 ARLLEGEPGPRDEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 397
            ..|:        :.||..|||.||.|..|||:||.|..|.....|.||||.:||.|:.||..:..
  Fly   362 GALM--------KSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLH 418

Human   398 DLRTKEK-------ELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQ 455
            |||.|||       |||::||:|||...|||.:...|:.|||.|.|||..::||||.:|     |
  Fly   419 DLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVML-----Q 478

Human   456 EKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPR 520
            ..|..||.|...|...|        .||||:||.|.||..          .|.|..|.||| ...
  Fly   479 PVPSKRKHKKGKKNKPL--------QISLPTGFRHTITAV----------RDKAEQPGSPS-FSG 524

Human   521 LRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLK 585
            ||.:.||                                ...||:|||||:..|:||.....:|.
  Fly   525 LRIVALT--------------------------------DGHKGKTWGPSTMHQRERSLLPSQLS 557

Human   586 GLGEGSKQW----------SSSAPNLGKSPKH---------TPIAPGFASLNEMEEFAEAEDGGS 631
            |   |..:|          |.|||||.|..:.         || .||...|.     .....||:
  Fly   558 G---GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTP-PPGLGILG-----GSGGAGGT 613

Human   632 SVPPSPY-STPSYLSVP------------------------------------------------ 647
            ...|..| ..|..|:.|
  Fly   614 PATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTIN 678

Human   648 ---------LPAEPSP------GARAPWEPTPSAPPARWGHGARRR---CDLAL----------- 683
                     |.::|:.      |.......|.|..||:..|.||.:   .|..|
  Fly   679 SNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVT 743

Human   684 ------------LGCATLL---------GAVGL---GADVAEARAADGEEQRRWLDGLFFPRAG- 723
                        .||...|         |||.|   |..:..:.|. |.::.........|.|.
  Fly   744 DDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAV-GRKKHSLDSSSHHPPANG 807

Human   724 ----RFPRGLSPPAR-----PHGRREDVGPGLGLAPSATLVSLSS--VSDCNSTRSLLRSDSDEA 777
                ..|..|:.|:.     .|....||...:.:|.|..:.|.||  ::..||:..|...|.|:|
  Fly   808 SNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTPLTARDCDDA 872

Human   778 APAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGAL 842
            ..|                        .|...|:::...|..|.|    |..:|..
  Fly   873 EEA------------------------FEGGRFQRNFSGSQFPRH----CFFTRQE--------- 900

Human   843 GQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPA-RRRPPEFPGRPTTLT----------FAPRPR 896
             :.|..|.........|..|..  .|.:...|| :.|......|.:::|          |...||
  Fly   901 -EEGEAEDEDAVAAEVDTADAD--ADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPR 962

Human   897 PAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPT 938
            ..|..........:||....:.||.....:..:...||:..|
  Fly   963 TTARSDLYTSSASISFATYRSASPSLSSSSTTASASPSIAST 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	33/55 (60%)
		TyrKc	98..365	CDD:197581	166/266 (62%)
		PKc_like	103..368	CDD:304357	166/264 (63%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	34/57 (60%)
		TyrKc	129..386	CDD:197581	166/266 (62%)
		STKc_MLK	134..389	CDD:270963	166/264 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1091
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm42198
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4635
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800