Protein Alignment MAP3K10 and wnd

DIOPT Version :10

• Sequence 1: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Sequence 2: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Alignment Length: 931
• Identity: 231/931 - (24%)
• Similarity: 347/931 - (37%)
• Gaps: 277/931 - (29%)

Human    92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPN 156
            :|||..:...|.:|.|..|.|:....:.|.||||..:...|.|           .:....|.|.|
  Fly   155 QIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETD-----------IKHLRKLDHEN 208

Human   157 IIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVP-PHVLVNWAVQVARGMNYLHNDAPVPIIH 220
            ||..:|.|...|..|::||:...|.|..:|...:|. |..||:|:.|:|.||.|||:.   .|||
  Fly   209 IIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSH---KIIH 270

Human   221 RDLKSINILILEAIENHNLADTVLKITDFGLAREWHK-TTKMSAAGTYAWMAPEVIRLSLFSKSS 284
            |||||.||||        ..:.|:||:|||.:|||:: :||||.|||.|||||||||....|:..
  Fly   271 RDLKSPNILI--------STNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKV 327

Human   285 DVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEGEPGPRDEECWD 349
            |:||:||:|||:||.|:||:::|:.|:.:||..|.|.|.:||||||.|..|:        :.||.
  Fly   328 DIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLV--------KLCWK 384

Human   350 PDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELL 414
            ..|..||.|..||..|::.....|.:...:.|.: |:.||.|::....::......:...|::|:
  Fly   385 SKPRNRPSFRQILSHLDIAGPELLRKTEKQYFET-QKSWKEEVRSHLKEITQNGTNIHKYEQDLI 448

Human   415 -------RAAQEQRF-QEEQLRRREQ----------ELAEREMDIVERELHLLMCQLSQEKPRVR 461
                   |.||:.|. .|::|::..|          :|.|:|.:|.|||               |
  Fly   449 KRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERE---------------R 498

Human   462 KRKGN-FKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASP---------- 515
            |..|: :|.:|..     |:.|.....:..::....:....:....|..:.|.||
  Fly   499 KLPGSGYKPNRRF-----GNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLD 558

Human   516 -SIIPRLRAIRLTPVDCGGSSSGSSS--------------GGSGTWSRGGPPKKEELVGGKKKGR 565
             :..|:.....:.|      |||..:              ..||::  |.|||
  Fly   559 SNCQPKSYLANIIP------SSGLGAPMPNKNKKVFRHRRNASGSF--GAPPK------------ 603

Human   566 TWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNL--------GKSPKHTPI---APGF----A 615
             :.|:   :..|...|...:.:....:|..:.|.::        .::|:..||   .|..    .
  Fly   604 -YSPT---RDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPL 664

Human   616 SLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPG-----ARAPWEPTPSAPP------- 668
            .|..:::.|:|:....|     .||.|......||.||.|     :...::...|:|.
  Fly   665 QLQRVQKIAQAQARARS-----GSTSSAAGAVNPACPSNGNSLSTSELTYQDACSSPDQLIDDVM 724

Human   669 ---------------------------------------------ARWGHGARRRCDL------- 681
                                                         |..|:|.....:|
  Fly   725 NSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGASPLELRESGNSP 789

Human   682 ALLGCATL--------LGAVGLGADVAEARAADGEEQRRWLD----------GLFFPRAGRFP-- 726
            .|..|::.        ||....|:.:..|. .:..||..|.|          .|.....||.|
  Fly   790 CLSRCSSTHSKRRKHPLGDNPNGSSIGNAN-GESHEQDSWSDEEGETTDYKYALRRRSIGRQPIA 853

Human   727 RGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPA- 790
            ||:.|      ||....|            ||.....:....::.||.:|........|.|..:
  Fly   854 RGMRP------RRSYKAP------------LSQKIAIHKRNVVIVSDEEENTSEYSHSPSSQHST 900

Human   791 -----------PTPTPSPSTNPLVDLELESF-KKDPRQSLTPTHVTAACAVSRGHRRTPSDGALG 843
                       .|...|.|:|...:.|.:|. ..|..|...||...|
  Fly   901 LESNTDIADMKKTQATSTSSNSYSEPEDDSSDSSDEEQGNRPTEAKA------------------ 947

Human   844 QRGPPEPAGHGPGPRDLLDFP 864
             .||..|.| .....|::..|
  Fly   948 -EGPALPMG-AVRSSDIISIP 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		Protein Kinases, catalytic domain	103..368	CDD:473864	112/266 (42%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	112/265 (42%)