DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K10 and Map3k10

DIOPT Version :9

Sequence 1:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens
Sequence 2:	NP_001382027.1	Gene:	Map3k10 / 308463	RGDID:	1308381	Length:	940	Species:	Rattus norvegicus

Alignment Length:	964	Identity:	881/964 - (91%)
Similarity:	898/964 - (93%)	Gaps:	26/964 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPS 65
            |||||||.|:|||.|||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat     1 MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPS 65

Human    66 GRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLD 130
            |||||||||||||.|||||..||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 GRVGVFPSNYVAPAAPAAPTDLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLD 130

Human   131 PEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV 195
            ||:|||||||||.||||||||||||||||||||||:||:||||||||||||||||||||||||||
  Rat   131 PERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHV 195

Human   196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK 260

Human   261 MSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIP 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 MSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIP 325

Human   326 STCPEPFARLLEGEPGPRDEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKL 390
            |||||||||||        |||||||||||||||||||:||||||||||||||||||||||||||
  Rat   326 STCPEPFARLL--------EECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKL 382

Human   391 EIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQ 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
  Rat   383 EIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQ 447

Human   456 EKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPR 520
            |||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
  Rat   448 EKPRVRKRKGNFKRSRLLKLREGSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPR 512

Human   521 LRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLK 585
            ||||||||||||      ||||||||||.||||||||||||||||||||||||||||.|||||||
  Rat   513 LRAIRLTPVDCG------SSGGSGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKERAGGEERLK 571

Human   586 GLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPA 650
            .|||||||||||||||||||||||:|||||||||||||||| |.|::||||||||||||.|||||
  Rat   572 ALGEGSKQWSSSAPNLGKSPKHTPMAPGFASLNEMEEFAEA-DEGNNVPPSPYSTPSYLKVPLPA 635

Human   651 EPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLD 715
            |.||.|:.|||| |:|.|:|.|||||||||||||||||||.|||||||||||||.||||||.|||
  Rat   636 EASPCAQPPWEP-PAATPSRPGHGARRRCDLALLGCATLLSAVGLGADVAEARAGDGEEQRGWLD 699

Human   716 GLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPA 780
            ||||||.|||||||||..||.||||:..||.|||||||||||||||||||||||||||||||||.
  Rat   700 GLFFPRPGRFPRGLSPTGRPGGRREETAPGFGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPT 764

Human   781 APSPPPS--PPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALG 843
            |||||||  |      ||||||||||:|||||||||||||||||||||.|||||||||||||||.
  Rat   765 APSPPPSLLP------PSPSTNPLVDVELESFKKDPRQSLTPTHVTAAHAVSRGHRRTPSDGALR 823

Human   844 QRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK 908
            ||.|||...|  ||||.||||||||||||||.||||.||||||||||||||||||||||||||||
  Rat   824 QREPPELTNH--GPRDPLDFPRLPDPQALFPTRRRPLEFPGRPTTLTFAPRPRPAASRPRLDPWK 886

Human   909 LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 962
            ||||||||:|||||||||||||||.||||||||||||||:||:|||||||:|||
  Rat   887 LVSFGRTLSISPPSRPDTPESPGPLSVQPTLLDMDMEGQSQDNTVPLCGAYGSH 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	54/55 (98%)
		TyrKc	98..365	CDD:197581	254/266 (95%)
		PKc_like	103..368	CDD:304357	251/264 (95%)
Map3k10	NP_001382027.1	Leucine-zipper 1	384..405		20/20 (100%)
		Leucine-zipper 2	419..440		20/20 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..599		104/114 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..658		11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..733		35/45 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..916		152/175 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696896
Domainoid	1	1.000	1054	1.000	Domainoid score	I1359
eggNOG	1	0.900	-	-		E2759_KOG0192
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1834
Inparanoid	1	1.050	1760	1.000	Inparanoid score	I1978
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38829
OrthoDB	1	1.010	-	-		D115270at2759
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		oto129663
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310