Protein Alignment MAP3K10 and Map3k10

DIOPT Version :10

• Sequence 1: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Sequence 2: XP_017177776.1
• Gene: Map3k10 / 269881
• MGIID: 1346879
• Length: 991
• Species: Mus musculus
• Alignment Length: 1005
• Identity: 887/1005 - (88%)
• Similarity: 906/1005 - (90%)
• Gaps: 57/1005 - (5%)

Human     1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPS 65
            |||||||.|:|||.|||||||||||||||.|||||||||||||||||||||||||||||||||||
Mouse     1 MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPS 65

Human    66 GRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLD 130
            |||||||||||||.|||||:.|||||||||||||||||||||||||||||:||||||||||||||
Mouse    66 GRVGVFPSNYVAPAAPAAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLD 130

Human   131 PEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV 195
            ||:|||||||||.||||||||||||||||||||||:||:||||||||||||||||||||||||||
Mouse   131 PERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHV 195

Human   196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK 260

Human   261 MSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIP 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 MSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIP 325

Human   326 STCPEPFARLLEGEPGPRDEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKL 390
            |||||||||||||||||..|||||||||||||||||||:||||||||||||||||||||||||||
Mouse   326 STCPEPFARLLEGEPGPCGEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKL 390

Human   391 EIQHMFDDLRTKEK-------------------------------------------ELRSREEE 412
            ||||||||||||||                                           ||||||||
Mouse   391 EIQHMFDDLRTKEKLVMSRLEGCELRADAHKTHLSWDPGPAPAAKPYLWACLPPSHQELRSREEE 455

Human   413 LLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLRE 477
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
Mouse   456 LLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNFKRSRLLKLRE 520

Human   478 GGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGG 542
            |.|||||||||||||||||||||||||||||||||||||||||||||||||:||||||      |
Mouse   521 GSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPMDCGGSS------G 579

Human   543 SGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKH 607
            ||||||.||||||||||||||||||||||||||||.|||||||.|||||||||||||||||||||
Mouse   580 SGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKERAGGEERLKALGEGSKQWSSSAPNLGKSPKH 644

Human   608 TPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWG 672
            ||:|||||||||||||||| |.|::||||||||||||.|||||||||..:||||| |:..|:|.|
Mouse   645 TPMAPGFASLNEMEEFAEA-DEGNNVPPSPYSTPSYLKVPLPAEPSPCVQAPWEP-PAVTPSRPG 707

Human   673 HGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHG 737
            ||||||||||||.|||||.|||||||||||||.||||||||||.|||||.|||||||||..||.|
Mouse   708 HGARRRCDLALLSCATLLSAVGLGADVAEARAGDGEEQRRWLDSLFFPRPGRFPRGLSPTGRPGG 772

Human   738 RREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPL 802
            ||||..|||||||||||||||||||||||||||||||||||||||||||||.|    ||||||||
Mouse   773 RREDTAPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPLA----PSPSTNPL 833

Human   803 VDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLP 867
            ||:|||||||||||||||||||||.|||||||||||||||.||.|.|...|  ||||.|||||||
Mouse   834 VDVELESFKKDPRQSLTPTHVTAAHAVSRGHRRTPSDGALRQREPLELTNH--GPRDPLDFPRLP 896

Human   868 DPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGP 932
            |||||||.||||.||||||||||||||||||||||||||||||||||||:|||||||||||||||
Mouse   897 DPQALFPTRRRPLEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLSISPPSRPDTPESPGP 961

Human   933 PSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 962
            |||||||||||||||:||:||||||.:|||
Mouse   962 PSVQPTLLDMDMEGQSQDNTVPLCGVYGSH 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	54/55 (98%)
		Protein Kinases, catalytic domain	103..368	CDD:473864	256/264 (97%)
Map3k10	XP_017177776.1	SH3_MLK1-3	20..76	CDD:212992	54/55 (98%)
		Protein Kinases, catalytic domain	103..368	CDD:473864	256/264 (97%)