Protein Alignment MAP3K10 and fin1

DIOPT Version :9

• Sequence 1: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Sequence 2: NP_593305.1
• Gene: fin1 / 2542237
• PomBaseID: SPAC19E9.02
• Length: 722
• Species: Schizosaccharomyces pombe
• Alignment Length: 694
• Identity: 161/694 - (23%)
• Similarity: 244/694 - (35%)
• Gaps: 228/694 - (32%)

Human   102 EIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQ--------------VCQEARLFGAL 152
            |.||.|.||::|           |..||   ||.|:.|::              :..|..:...|
pombe     8 ECIGHGSFGRIY-----------KVQRL---KDGALLAQKEIHFGNITRQEKQYIADEVNILRNL 58

Human   153 QHPNIIALRGACLN--PPHLCLVMEYARGGALSRVL-----AGRRVPPHVLVNWAVQVARGMNYL 210
            :||||:...|..||  ...:.|.|||...|.|:.::     ..:|.....::.:..|:...:...
pombe    59 KHPNIVQYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRC 123

Human   211 H--NDAPV--------------PIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTT 259
            |  .:||.              .::|||:|..||.:   .||::     :|:.||||::....|.
pombe   124 HYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFL---DENNS-----VKLGDFGLSKLLDNTR 180

Human   260 --KMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTL 322
              ..|..||..:|:||:||.|.:|..||||:.|.:::|:.....|:.....|.:...:....|:
pombe   181 VFTQSYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLS- 244

Human   323 PIPSTCPEPFARLLEGEPGPRDEECWD----------------------PDPH---GRPDFGSIL 362
                                    |||                      |..:   ..|....|.
pombe   245 ------------------------CWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIR 285

Human   363 KRLE----VIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQ 423
            .:||    |:|||.|          |.:..::.|| :.:||:.:|:.|.:||.||......:..|
pombe   286 SKLESERVVLEQSDL----------LHKKHQMLIQ-LENDLQFREQRLSARESELENVIASRLAQ 339

Human   424 EEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGN------------------FKRS 470
            .|::.|||.|...|:|| ...:.|:.....|.:|.||.....:                  ..:|
pombe   340 REEILRRELEKQLRDMD-ARYQRHMQTVVNSMQKMRVTSPVDHNEQPESSTAEMFVDCTIEASQS 403

Human   471 RLLKLREGGSHISLP------SGFEHKITVQ----ASPTLDKRKGSDGASPPASPSIIPRLRA-- 523
            .||.:.:.|  ||.|      .||  .:|.|    ..|||.|...|......|:   :.:.||
pombe   404 PLLHIPKLG--ISKPLQTLSCPGF--TLTTQQPILKRPTLRKELSSRALHTTAT---LMKYRANA 461

Human   524 --IRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKG 586
              :|.||:|..|..: |....:|| |........:|:.....|:...||....|...|     :|
pombe   462 SSLRTTPIDKDGQIT-SLQQKNGT-SNQVADCMNKLLHTSLDGKKLSPSELCNKFSDG-----EG 519

Human   587 LGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSV-----------------P 634
            |           ||...|....          |.:|.|.:...|.||                 |
pombe   520 L-----------PNRKVSKLSV----------ESDETAVSASSGESVPTDSTLTDTKSKSVFVHP 563

Human   635 PSP-----------------YSTPSYLSVPLPAEPSPGARAPWE 661
            |||                 .|.||..|..|.....|...:|::
pombe   564 PSPQSLYVEKLEKLNIRSDEVSKPSKASKTLHGYALPSLASPYD 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		TyrKc	98..365	CDD:197581	73/326 (22%)
		PKc_like	103..368	CDD:304357	74/332 (22%)
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	72/319 (23%)
		S_TKc	4..281	CDD:214567	72/319 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910