DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppox and HEMG2

DIOPT Version :9

Sequence 1:	NP_651278.2	Gene:	Ppox / 42939	FlyBaseID:	FBgn0020018	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001331495.1	Gene:	HEMG2 / 831272	AraportID:	AT5G14220	Length:	556	Species:	Arabidopsis thaliana

Alignment Length:	504	Identity:	130/504 - (25%)
Similarity:	226/504 - (44%)	Gaps:	73/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVLGGGLSGLSAGYYLLRRFGKPLTIYEASPRVGGWVRSENRKDRNFIFESGPRTIRPVGEPGAN 68
            ||:|.|:|||:|.|.|..| |..:|::||..||||.:||        :.::|     .:.:.|||
plant    68 AVVGAGVSGLAAAYKLKSR-GLNVTVFEADGRVGGKLRS--------VMQNG-----LIWDEGAN 118

  Fly    69 TL--------ELVEDLKLEVTPIRRSHVAARNRMLYAKGQLCMLPNSPKGLFGVLPPFTKPLYKA 125
            |:        .|::||.|...  ::..::.:.|.:...|...|||.:|..|.......|:..::.
plant   119 TMTEAEPEVGSLLDDLGLREK--QQFPISQKKRYIVRNGVPVMLPTNPIELVTSSVLSTQSKFQI 181

  Fly   126 VLRDLFTASKKAKLED----ESIYSFAERRFGKEIADYAISPMICGICAGDAREISVRFLMEGLF 186
            :|.......|.:|:.|    ||:..|.:|.||:|:.||.|.|.:.|..|.|...:|::.....|:
plant   182 LLEPFLWKKKSSKVSDASAEESVSEFFQRHFGQEVVDYLIDPFVGGTSAADPDSLSMKHSFPDLW 246

  Fly   187 EKEQKYGGVLKGTLISRF--EKNKTKDTKDGLFAERQPKLYAQAVKEKWAMYGLKGGLENLPKTM 249
            ..|:.:|.::.|.:.::|  :..|::|||.....::..:          ..:..|||::.||.|:
plant   247 NVEKSFGSIIVGAIRTKFAAKGGKSRDTKSSPGTKKGSR----------GSFSFKGGMQILPDTL 301

  Fly   250 RKYLGERDVNVQLSNECRNLTFSSSGVRMNIKDAEVPVEHVVSSLPAY----KLAPL--VKQQHP 308
            .|.|...::|  |.::..:|:::|...:.|...:.|.........|.|    ..|||  ||:...
plant   302 CKSLSHDEIN--LDSKVLSLSYNSGSRQENWSLSCVSHNETQRQNPHYDAVIMTAPLCNVKEMKV 364

  Fly   309 SLSAQ------LLSIPYVDVLVVNMQFPGKLLKQ--DGFGLLVPPVEK---LPLLGVIFDSCCF- 361
            ....|      |..|.|:.:.|:...|..:.:|:  :|||:|:|..|:   ...||.:|.|..|
plant   365 MKGGQPFQLNFLPEINYMPLSVLITTFTKEKVKRPLEGFGVLIPSKEQKHGFKTLGTLFSSMMFP 429

  Fly   362 DMGENTV--LTVMMGGHWFDQWFGDRPSPKQILDLATSHVQKMLQIREEPKFSRVHTLHKCIPQY 424
            |...:.|  .|..:||....:.  .:.|..::..:.||.:|::|.:..||.....:...|..|.|
plant   430 DRSPSDVHLYTTFIGGSRNQEL--AKASTDELKQVVTSDLQRLLGVEGEPVSVNHYYWRKAFPLY 492

  Fly   425 TVGHKRRVEAIRN---------YIKTYKLPLSVCGAAYDGVGINDVILS 464
            ...:...:|||..         |...::..|||..:...|....|:::|
plant   493 DSSYDSVMEAIDKMENDLPGFFYAGNHRGGLSVGKSIASGCKAADLVIS 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppox	NP_651278.2	HemY	17..472	CDD:224153	122/491 (25%)
Ppox	NP_651278.2	NAD_binding_8	18..76	CDD:290186	18/65 (28%)
HEMG2	NP_001331495.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	119	1.000	Domainoid score	I1904
eggNOG	1	0.900	-	-		E1_COG1232
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I1905
OMA	1	1.010	-	-		QHG62496
OrthoDB	1	1.010	-	-		D1578484at2759
OrthoFinder	1	1.000	-	-		FOG0004156
OrthoInspector	1	1.000	-	-		otm2785
orthoMCL	1	0.900	-	-		OOG6_101704
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4516
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740