DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppox and PPOX

DIOPT Version :9

Sequence 1:	NP_651278.2	Gene:	Ppox / 42939	FlyBaseID:	FBgn0020018	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_011507965.1	Gene:	PPOX / 5498	HGNCID:	9280	Length:	567	Species:	Homo sapiens

Alignment Length:	458	Identity:	169/458 - (36%)
Similarity:	245/458 - (53%)	Gaps:	40/458 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TTAVLGGGLSGLSAGYYLLRRFGKP-LTIYEASPRVGGWVRSENRKDRNFIFESGPRTIRPVGEP 65
            |..|||||:|||:|.|:|.|....| :.:.|:|.|:|||:||. |.....|||.|||.|||.|..
Human    42 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSV-RGPNGAIFELGPRGIRPAGAL 105

  Fly    66 GANTL-----ELVEDLKL--EVTPIRRSHVAARNRMLYAKGQLCMLPNSPKGLFGVLPPFTKPLY 123
            ||.||     |.|.:|.|  ||.|:|..|.||:||.||..|.|..||...:||....|||:|||:
Human   106 GARTLLLACGEQVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLF 170

  Fly   124 KAVLRDLFTASKKAKLEDESIYSFAERRFGKEIADYAISPMICGICAGDAREISVRFLMEGLFEK 188
            .|.||:|  ...:.|..||:::|||:||.|.|:|..|:..:..|:.||::||:|:|.....||:.
Human   171 WAGLREL--TKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQA 233

  Fly   189 EQKYGGVLKGTLISRFEKNKTKDTKDGLFAERQPK----LYAQAVKEKWAMYGLKGGLENLPKTM 249
            ||.:..:|.|.|:.               |.|.|:    |..||:.|:|:.:.|:||||.||:.:
Human   234 EQTHRSILLGLLLG---------------AGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL 283

  Fly   250 RKYLGERDVNVQLSNECRNLTFSSSG-VRMNIKDAEVPVEHVVSSLPAYKLAPLVKQQHPSLSAQ 313
            ..:|..|.|:|........|:..:.| .:::::|:.:..:||:|::||..|:.|:..:...|:..
Human   284 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARA 348

  Fly   314 LLSIPYVDVLVVNMQFPGKLLKQDGFGLLVPPVEKLPLLGVIFDSCCFDMGENTV----LTVMMG 374
            |.:|..|.|.|||:|:.|..|...|||.|||..|...:||:::||..|...:.:.    :|||:|
Human   349 LSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG 413

  Fly   375 GHWFD--QWFGDRPSPKQILDLATSHVQKMLQIREEPKFSRVHTLHKCIPQ--YTVGHKRRVEAI 435
            |.|..  :..|...|.:.....|.......|.::|.|....|| |||...|  :...|.|.||..
Human   414 GSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVH-LHKTKNQLKWRQSHDRTVEWP 477

  Fly   436 RNY 438
            :.|
Human   478 KEY 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppox	NP_651278.2	HemY	17..472	CDD:224153	159/443 (36%)
Ppox	NP_651278.2	NAD_binding_8	18..76	CDD:290186	28/63 (44%)
PPOX	XP_011507965.1	NAD_binding_8	45..103	CDD:290186	31/58 (53%)
PPOX	XP_011507965.1	NADB_Rossmann	<270..>404	CDD:304358	44/133 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158948
Domainoid	1	1.000	291	1.000	Domainoid score	I1540
eggNOG	1	0.900	-	-		E1_COG1232
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H262
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2673
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62496
OrthoDB	1	1.010	-	-		D1578484at2759
OrthoFinder	1	1.000	-	-		FOG0004156
OrthoInspector	1	1.000	-	-		oto88426
orthoMCL	1	0.900	-	-		OOG6_101704
Panther	1	1.100	-	-	LDO	PTHR42923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R976
SonicParanoid	1	1.000	-	-		X4516
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800