DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppox and Ppox

DIOPT Version :9

Sequence 1:	NP_651278.2	Gene:	Ppox / 42939	FlyBaseID:	FBgn0020018	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_032937.1	Gene:	Ppox / 19044	MGIID:	104968	Length:	477	Species:	Mus musculus

Alignment Length:	484	Identity:	184/484 - (38%)
Similarity:	274/484 - (56%)	Gaps:	30/484 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TTAVLGGGLSGLSAGYYLLRRFGKP-LTIYEASPRVGGWVRSENRKDRNFIFESGPRTIRPVGEP 65
            |..|||||:|||:|.|:|:|....| :.:.|.|.|:|||:||....| ..|||.|||.|||.|..
Mouse     4 TVIVLGGGISGLAASYHLIRGPSPPKVILVEGSKRLGGWIRSIRGSD-GAIFELGPRGIRPAGAL 67

  Fly    66 GANTLELVEDLKL--EVTPIRRSHVAARNRMLYAKGQLCMLPNSPKGLFGVLPPFTKPLYKAVLR 128
            ||.||.||.:|.|  ||.|:|..|.||:||.||..|.|..||:..:||....|||:|||:.|.||
Mouse    68 GARTLLLVSELGLESEVLPVRGDHPAAQNRFLYVGGTLHPLPSGLRGLLRPSPPFSKPLFWAGLR 132

  Fly   129 DLFTASKKAKLEDESIYSFAERRFGKEIADYAISPMICGICAGDAREISVRFLMEGLFEKEQKYG 193
            :|.  ..:.|..||:::|||:||.|.|:|..|:..:..|:.||::||:|:|.....||:.||.:.
Mouse   133 ELL--KPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHR 195

  Fly   194 GVLKGTLISRFEKNKTKDTKDGLFAERQP--KLYAQAVKEKWAMYGLKGGLENLPKTMRKYLGER 256
            .:|.|.|:             |.....||  .|..||..|:|:.:.|:||||.||:.:..:|..:
Mouse   196 SILLGLLL-------------GAGQSPQPDSSLIRQARAERWSQWSLRGGLEVLPQALHNHLASK 247

  Fly   257 DVNVQLSNECRNLTFSSSG-VRMNIKDAEVPVEHVVSSLPAYKLAPLVKQQHPSLSAQLLSIPYV 320
            .|.|........|:....| .::::.|:.:..:|::|::||.:|:.|:..:...|:..|.:|..|
Mouse   248 GVTVLSGQPVCGLSLQPEGRWKVSLGDSSLEADHIISAIPASELSKLLPAEAAPLARILSTIKAV 312

  Fly   321 DVLVVNMQFPGKLLKQDGFGLLVPPVEKLPLLGVIFDSCCFDMGENTV----LTVMMGGHWFDQW 381
            .|.|||:|:.|..|...|||.|||..|...:||:::||..|...:...    :|||:||:|..:.
Mouse   313 SVAVVNLQYRGACLPVQGFGHLVPSSEDPTVLGIVYDSVAFPEQDGNPPSLRVTVMLGGYWLQKL 377

  Fly   382 --FGDRPSPKQILDLATSHVQKMLQIREEPKFSRVHTLHK-CIPQYTVGHKRRVEAIRNYIKTYK 443
              .|.:.||:.....|.......|.::|.|....|| ||| ||||||:||.:::::...::...:
Mouse   378 KAAGHQLSPELFQQQAQEAAATQLGLKEPPSHCLVH-LHKNCIPQYTIGHWQKLDSAMQFLTAQR 441

  Fly   444 LPLSVCGAAYDGVGINDVILSARRQVEAI 472
            |||::.||:|:||.:||.|.|.|:...|:
Mouse   442 LPLTLAGASYEGVAVNDCIESGRQAAVAV 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppox	NP_651278.2	HemY	17..472	CDD:224153	173/467 (37%)
Ppox	NP_651278.2	NAD_binding_8	18..76	CDD:290186	28/58 (48%)
Ppox	NP_032937.1	proto_IX_ox	3..471	CDD:213540	183/479 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849328
Domainoid	1	1.000	294	1.000	Domainoid score	I1494
eggNOG	1	0.900	-	-		E1_COG1232
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H262
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2617
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62496
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004156
OrthoInspector	1	1.000	-	-		oto91997
orthoMCL	1	0.900	-	-		OOG6_101704
Panther	1	1.100	-	-	LDO	PTHR42923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R976
SonicParanoid	1	1.000	-	-		X4516
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790