DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppox and spr-5

DIOPT Version :9

Sequence 1:	NP_651278.2	Gene:	Ppox / 42939	FlyBaseID:	FBgn0020018	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_493366.1	Gene:	spr-5 / 173214	WormBaseID:	WBGene00005010	Length:	770	Species:	Caenorhabditis elegans

Alignment Length:	510	Identity:	104/510 - (20%)
Similarity:	161/510 - (31%)	Gaps:	169/510 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLGGGLSGLSAGYYLLRRFGKPLTIYEASPRVGGWVRSENRKDRNFIFESGPRTIRPVGEPGANT 69
            |:|.|.:|:||... |..||..:.:.||...:||.:.|       |..:||     .:.|.|.:|
Worm   139 VIGAGAAGISAATQ-LESFGFDVIVLEARNCIGGRIHS-------FKSKSG-----EIMETGGDT 190

  Fly    70 LELVEDLKLEVTPIRRSHVAARNRMLYAKGQLCMLPNSPKGLFGVLPPFTKPLYKAVLRDLFTAS 134
            |..:||..:...                   |..:.....|:|    .||         .:|...
Worm   191 LRKIEDSPMATL-------------------LHQVNFEEHGVF----DFT---------SVFVEG 223

  Fly   135 KKAKLEDESIYSFAERRFGKEIADYAISPMICGICAGDAREISVRFLMEGLFEKEQKYGGVL--- 196
            :  .|.:|.|:.|.:......           |.....|.:...|........::|.|..:|
Worm   224 R--PLNEEKIHLFLDHYKSAH-----------GALNYQAHQCEHRDDQGSFISRQQAYENLLSMC 275

  Fly   197 -KGTLISRFEKNKTKDT----------------KDGLFAERQPKLYAQAVKEKWAMYGLKGGLEN 244
             :||||..:...|:.:|                ...|.||.|.|...:           :|.||.
Worm   276 ERGTLIKYYNFCKSLETVARAREHHFNQMKQLRMTALMAENQLKKMEE-----------EGNLEQ 329

  Fly   245 LPKTMRKYLGERDVNVQLS--NECRNL--TFSSSGVRMNIKDAEVPVEHVVSSLPAYKLAPLVKQ 305
            .| .:|:.| :||:...|.  .|..:.  |..:...|:|        ||           |..||
Worm   330 DP-VLRRSL-KRDIATSLEKFEEVADAFETADNHWQRLN--------EH-----------PQAKQ 373

  Fly   306 -QHPS----------------LSAQLLSIPYVDVLVVNMQFPGKLLKQDGFGLLVPPVEKLPLLG 353
             .||.                :.|||..:.:....:.|.:........:|...|:..:.:...|.
Worm   374 YMHPGSEFATFNFMLGFEEYLVGAQLEKVQFSCDSMQNKENGVAARLTEGIAELLTQLSEKRKLD 438

  Fly   354 VIFDSCCFDMG----ENTVLTVMMGGHWFDQWFGDRPSPKQILDLAT--SHVQKMLQIREEPKFS 412
            :.......|:.    |:.:|.|....       ||....|....::|  ..|.|...|.:|
Worm   439 IRLKHRVLDIDYSGFEHVLLKVQREN-------GDIEEMKAAFVVSTLPIGVLKKTIIADE---- 492

  Fly   413 RVHTLHKCIPQYTVGHKRRVEAIRNYIKTYKLPLSVCGAAYDGVGINDVILSARR 467
            |..|....:|.      ::||||||.         .||:      :|..||...|
Worm   493 RAPTFTPSLPD------KKVEAIRNI---------GCGS------VNKCILEFDR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppox	NP_651278.2	HemY	17..472	CDD:224153	98/498 (20%)
Ppox	NP_651278.2	NAD_binding_8	18..76	CDD:290186	16/57 (28%)
spr-5	NP_493366.1	SWIRM	36..117	CDD:282311
spr-5	NP_493366.1	Amino_oxidase	151..676	CDD:279874	98/498 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930