DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6695 and F28C1.1

DIOPT Version :9

Sequence 1:	NP_651276.2	Gene:	CG6695 / 42937	FlyBaseID:	FBgn0039215	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_506124.1	Gene:	F28C1.1 / 179705	WormBaseID:	WBGene00009200	Length:	672	Species:	Caenorhabditis elegans

Alignment Length:	823	Identity:	241/823 - (29%)
Similarity:	354/823 - (43%)	Gaps:	204/823 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWHEARKQERKIRGLIVDYRKRAERRQYFYDKIQADPTQFLQLHGRRSKIYLDPAVAAAGDGAAI 65
            ||||||:||:.:|..::|..|||||::.:::.::.||.||:|:|||:::|:.|..:|.|.:.|.|
Worm     1 MWHEARRQEKILRTTMIDQSKRAERKRRYFENVRKDPDQFMQIHGRKAQIHADLGIARAAEDANI 65

  Fly    66 IVPWQGQQDNLIDRFDVRAHL--------DHIPPVNKTNAEGADGDSELTLEERQL--NYERYRI 120
            :.||||.....|||||.|:||        |.|.|..||         |:..|:.|:  ::||||:
Worm    66 LRPWQGDSTITIDRFDARSHLSKMDLVDIDEIIPKTKT---------EIVDEKEQIVTDFERYRV 121

  Fly   121 LAQNDFLNVSEDKFLHQLYLEEQFGA----NAQLEAERNLAKKKQKTGGATIGYSYEDTGDGATI 181
            |..||:..|||..:|.::...|.:.|    |.::|.|:   |||.....:|||:||:|
Worm   122 LIINDYKKVSEKHYLKKIADREFWCAEKDNNRKVETEK---KKKSAEKKSTIGFSYDD------- 176

  Fly   182 GPQPFGAASSTVIGGAAAVAKGEK----GDGSEESDSDI-DMDVSIDIGKLDTSQAHELNACGRN 241
                    |..|.||     |.||    ||..||...|: |:||.:|...|:......:|..|..
Worm   177 --------SEVVKGG-----KDEKYNSDGDSEEEEMDDMQDLDVDLDTSILNPETQRTVNKSGEE 228

  Fly   242 YGMKSNDFFSHLTKDADEADALRIA---REEEQEKMLLSGRKSRRER---RAQKERRIANRPFSP 300
            :|:|...|.:.|..|   ..|||.|   ::.:::|..||||:|:.||   |.|::..:..|....
Worm   229 FGVKRGLFCALLKAD---QQALRDAAQLKQIDRQKAALSGRESKHERMLLRQQRQAIVGKRGMVV 290

  Fly   301 PSYAAKE------DKDKKGGGKGGEKEKEEDSE-SRSPSPAEAGPEKITYITSFGGEDEMQPHSK 358
            ....|..      ::.:|   |....|..||.| |.:.....|.||   :||:|||..:.....:
Worm   291 SENGATATLLGFINQSQK---KSKVDELIEDMEGSDNDDDRRAKPE---FITTFGGGADRDSDDE 349

  Fly   359 ITISLTKPGLTLGE--SCINASSGAAIAAAAASSVSYAQKVKDNLD--KLKVMNESSKRNRRR-S 418
            |...:..|.|...|  ..:..|..             .:|..|.:|  .|||...:...|||. |
Worm   350 IKKEIVGPELPSEEYRKILKLSQN-------------RRKDDDAVDWGNLKVGGGNGGMNRRSWS 401

  Fly   419 RSHSRSRSRSATVSRSRSGSRRSGSRRRSRRSRSYHRRSRTRSRRRRRYYSRSRSRSRSRSRSLS 483
            ||.|||||||....||||.| |:..|||.|||.| .||||:|.|:|     |||||.|.|.....
Worm   402 RSRSRSRSRSPPRRRSRSRS-RTRDRRRPRRSNS-RRRSRSRDRQR-----RSRSRDRRRYSPDR 459

  Fly   484 RSRSRSRSRSRSGSWKRYKARSPSYKRSRKRYSYSSRSSSGSSYRRRSRSRSPSNRRSRVKKKTT 548
            |.|.|||||.|    :|:::||.|.:|.|            |..|||.|||..|......|::|
Worm   460 RERRRSRSRDR----RRHRSRSTSRRRQR------------SKDRRRDRSRDRSRDERNEKRRT- 507

  Fly   549 PPPVATVGGYCLNTTTTTTTSTVTAVKMFQQQQQQPPAKATPPMISYPIPA-----RMLNVNQAL 608
                        :.........|:.|    ..:::||.|...|..|....:     :||.:..::
Worm   508 ------------SKNVVRQDDVVSCV----VSEEKPPVKVDEPRESSAEDSDSDHVKMLEIRSSM 556

  Fly   609 TATAPVAVQPQVVEPPPPPLKRYYGRKRGNDTSSSSSSGAENSEGSDNEEQQQPQLGKRAEDSDD 673
            :.:.....:.:..:......|:....|||..::..||                        |.||
Worm   557 SDSEKEKAEIENRKRRVKLTKKLIKEKRGQTSNDRSS------------------------DEDD 597

  Fly   674 MELDTASERSHALQPTMSSSSSTGNQTGKYSSATETKGSGHPSSGGGGRPNLRERLKRKMQNLLN 738
            .|....:|::..::..||                                   :.||:..|.|..
Worm   598 GEQQWKTEQARRVKMQMS-----------------------------------QALKKTRQELAK 627

  Fly   739 RQYKADKRAEIEKTERERLQQQEREDEMRELALKLRRRRRELR 781
            .:  .|::.|.|..:|.|       ||:|.:..:.||.|...:
Worm   628 EE--EDRKKEAEVAQRVR-------DELRYIETQERRERERAK 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6695	NP_651276.2	DRY_EERY	41..174	CDD:286793	54/146 (37%)
F28C1.1	NP_506124.1	DRY_EERY	41..176	CDD:370659	54/146 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167522
Domainoid	1	1.000	87	1.000	Domainoid score	I5104
eggNOG	1	0.900	-	-		E1_KOG2548
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I2195
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006252
OrthoInspector	1	1.000	-	-		oto18020
orthoMCL	1	0.900	-	-		OOG6_108501
Panther	1	1.100	-	-	LDO	PTHR13161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3786
SonicParanoid	1	1.000	-	-		X4535
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780