DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash2 and TRO

DIOPT Version :9

Sequence 1:	NP_788735.1	Gene:	ash2 / 42936	FlyBaseID:	FBgn0000139	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_175556.1	Gene:	TRO / 841570	AraportID:	AT1G51450	Length:	509	Species:	Arabidopsis thaliana

Alignment Length:	559	Identity:	145/559 - (25%)
Similarity:	223/559 - (39%)	Gaps:	136/559 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MDTSSPTESSSEVNFTAEEDKSQETRSAAGVCYC-------------GKERNLNIVELLCATCSR 57
            :|.|:|.|||..|      ::|.||.|.|.|...             .:|.:|..:|      |.
plant    42 VDDSAPPESSDAV------EESIETASEAEVSISLLEGTTTGTALLPSEENDLAPLE------SS 94

  Fly    58 WVHETCVSYQLGKGKLLPFITNYVFVCKNCSASGL----ESFRKSQATISQMCHCAIANMQQAAS 118
            .:.|..:...|.|       .:.|.:..:...|.|    :||.:...|.|...:.....:...|:
plant    95 GIIEEPIDTDLEK-------LDVVAMDVDQPGSDLKIESDSFSEEAPTTSSSDNPKSPKLDSVAN 152

  Fly   119 RDGRRQIQFSKDKEIIPYIEQYWEAMTTMP-RRLTQSWYSTVQRSLVKDVQTLFTYEEHAEHGAM 182
            ::|....:...|:|           ....| ::|.|           .|..|....:|..|.
plant   153 QNGSAMEEDEGDEE-----------QDDPPHKKLKQ-----------LDCLTSVAVKEEEEP--- 192

  Fly   183 YGLFHQDLRIIKPNYESMSKSGALRLTDDGYTQASLSKNNRQKRKFPGTDSGPTGKKGRPSSDIT 247
                           |.:..|.|:.:.:.....||.:|.::.|:|........:.:||:..|  .
plant   193 ---------------EQVLPSEAMVVEEAATLVASAAKKSKSKKKNNNVWVTKSTRKGKKKS--K 240

  Fly   248 ANVKLPPHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRILVPHSVLLA 312
            ||.   |:...:|..        :|..|.|..|  .:.|::.|.                .:.|:
plant   241 ANT---PNPAAVEDK--------VLITPVPRFP--DKGDDTPDL----------------EICLS 276

  Fly   313 LHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIEEMPDGAATRLGWGREYGNLQA 377
            ...:|.:::||||||.....:||.|||||..|..|.||||:.:..:.:...|||||..:.|:|||
plant   277 KVYKAEKVEISEDRLTAGSSKGYRMVRATRGVVEGAWYFEIKVLSLGETGHTRLGWSTDKGDLQA 341

  Fly   378 PLGYDKFGYSWRSRKGTKFTESHGKHYS-DAYVEGDTLGFLIELPEEASLDYLPNTFKDRP--LV 439
            |:|||...:.:|...|.|..::..:.|: :.|.|||.:||.|.||:..|       |..:|  .|
plant   342 PVGYDGNSFGFRDIDGCKIHKALRETYAEEGYKEGDVIGFYINLPDGES-------FAPKPPHYV 399

  Fly   440 KFKSHLYYEDKDKITETLKNLHILQGSRIEFFKNGQSQGVAFEDIYAGSYFPAISIH-----KSA 499
            .:|...|....|...|..|   ::.||.|.|||||..||.||.||..|.|:||.|::     .:.
plant   400 FYKGQRYICAPDAKEEPPK---VVPGSEISFFKNGVCQGAAFTDIVGGRYYPAASMYTLPDQSNC 461

  Fly   500 TVSVNFGPAFKY----------PEVLVEHKAKGMHDRVE 528
            .|..||||:|::          |..:.|....|.:.|:|
plant   462 LVKFNFGPSFEFFPEDFGGRATPRPMWEVPYHGFNGRLE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash2	NP_788735.1	PHD_ash2p_like	36..87	CDD:277058	9/63 (14%)
ash2	NP_788735.1	SPRY_Ash2	320..510	CDD:293932	78/197 (40%)
TRO	NP_175556.1	SPRY_Ash2	284..471	CDD:293932	78/196 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I3588
eggNOG	1	0.900	-	-		E1_KOG2626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D444178at2759
OrthoFinder	1	1.000	-	-		FOG0004969
OrthoInspector	1	1.000	-	-		oto2902
orthoMCL	1	0.900	-	-		OOG6_102272
Panther	1	1.100	-	-	LDO	PTHR10598
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4622
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780