DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash2 and ash2l

DIOPT Version :9

Sequence 1:	NP_788735.1	Gene:	ash2 / 42936	FlyBaseID:	FBgn0000139	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001103575.2	Gene:	ash2l / 558193	ZFINID:	ZDB-GENE-030131-494	Length:	590	Species:	Danio rerio

Alignment Length:	569	Identity:	275/569 - (48%)
Similarity:	362/569 - (63%)	Gaps:	34/569 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MDTSSPTESSS--EVNFTA-EEDKSQETRSAAGVCYCGKERNLNIVELLCATCSRWVHETCVSYQ 67
            :.|:..|||||  |...|| :..::.:.::.:|....|  |.|..|||.||.|.:|.  |..::.
Zfish    23 LTTNMETESSSGKETMDTAGDSSEAADAQTGSGDDENG--RQLGEVELQCALCMKWF--TADTFS 83

  Fly    68 LGKGKLLPFITNYVFVCKNCSASGLESFRKSQATISQMCHCAIANMQ-QAASRDGRRQIQFSKDK 131
            :.....|||:|||||.|..|..||...|.:.||.:.:||..|:||:. ::.:::...:..|||||
Zfish    84 IDTATCLPFMTNYVFHCNVCHHSGNTYFLRKQANLKEMCLTALANLTWRSRTQEEHPKTMFSKDK 148

  Fly   132 EIIPYIEQYWEAMTTMPRRLTQSWYSTVQRSLVKDVQTLFTYEEHAEHGA--------MYGLFHQ 188
            :|||:|::|||.|||..|....:|.:.:.:::.|: :.:|..:||.:.|:        .:||..|
Zfish   149 DIIPFIDKYWECMTTRQRPGKLTWPNNIVKTMSKE-RDVFLVKEHPDPGSKDPEEDYPKFGLLDQ 212

  Fly   189 DLRIIKPNYESMSK----SGALRLT-----DDGYTQASLSKNNRQKRK-FPGTDSGPTGKKGRPS 243
            ||..|.|:|::..:    :||..|.     ..|...|:..|....||| ....|...||...|..
Zfish   213 DLGNIGPSYDNQKQMTTVTGAGGLNGGSTFSGGLPSAATGKGRGAKRKQQQQQDGAATGAAKRTR 277

  Fly   244 SD-ITANVKLPPHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRILVPH 307
            || :.:..:|||||||||||||||||||||||||||||..::. |...||||||||.|||..:..
Zfish   278 SDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKL-ELDCWAGKPIPGDLYRACLYE 341

  Fly   308 SVLLALHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIEEMPDGAATRLGWGREY 372
            .|||||||||||||||:|||.||||:||.||||:|.|.:|.|:||||::|||..||.||||.:..
Zfish   342 RVLLALHDRAPQLKISDDRLTVTGEKGYSMVRASHGVRKGSWFFEVTVDEMPQDAAARLGWSQPL 406

  Fly   373 GNLQAPLGYDKFGYSWRSRKGTKFTESHGKHYSDAYVEGDTLGFLIELPEEA-SLDYLPNTFKDR 436
            ||||||||||||.|||||:|||:|.:|.||||||.|..||.|||.||||:|. :...||:|:||:
Zfish   407 GNLQAPLGYDKFSYSWRSKKGTRFHQSIGKHYSDGYGLGDILGFFIELPDETETAKALPDTYKDK 471

  Fly   437 PLVKFKSHLYYEDKDKITETLKNLHILQGSRIEFFKNGQSQGVAFEDIYAGSYFPAISIHKSATV 501
            .|:||||:||:|:||.:.:..|||.....||:.|||||.:||||:||::.|.|:||||::|..||
Zfish   472 ALIKFKSYLYFEEKDYVDKAEKNLKPTSTSRMIFFKNGVNQGVAYEDLFEGMYYPAISLYKGCTV 536

  Fly   502 SVNFGPAFKYPEVLVEHKAKGMHDRVEELITEQCLADTLY--LTEHDGR 548
            ||||||.||||.  .:.|.:.|.|.....:.|..|||.||  .||.|||
Zfish   537 SVNFGPHFKYPP--KDIKFQPMSDMGWGAVIEHTLADMLYHVETEVDGR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash2	NP_788735.1	PHD_ash2p_like	36..87	CDD:277058	20/50 (40%)
ash2	NP_788735.1	SPRY_Ash2	320..510	CDD:293932	119/190 (63%)
ash2l	NP_001103575.2	PHD_ash2p_like	58..103	CDD:277058	20/48 (42%)
ash2l	NP_001103575.2	SPRY_Ash2	354..545	CDD:293932	119/190 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574757
Domainoid	1	1.000	258	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E1_KOG2626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3436
Inparanoid	1	1.050	486	1.000	Inparanoid score	I1396
OMA	1	1.010	-	-		QHG53232
OrthoDB	1	1.010	-	-		D444178at2759
OrthoFinder	1	1.000	-	-		FOG0004969
OrthoInspector	1	1.000	-	-		oto40318
orthoMCL	1	0.900	-	-		OOG6_102272
Panther	1	1.100	-	-	LDO	PTHR10598
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R95
SonicParanoid	1	1.000	-	-		X4622
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800