Protein Alignment ash2 and Ash2l

DIOPT Version :10

• Sequence 1: NP_788735.1
• Gene: ash2 / 42936
• FlyBaseID: FBgn0000139
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_006253365.1
• Gene: Ash2l / 290829
• RGDID: 1305632
• Length: 629
• Species: Rattus norvegicus
• Alignment Length: 568
• Identity: 271/568 - (47%)
• Similarity: 352/568 - (61%)
• Gaps: 34/568 - (5%)

  Fly     6 MDTSSPTESSSEVNFTAE--EDKSQETRSAAGVCYCGKERNLNIVELLCATCSRWVHETCVSYQL 68
            :|.|.....||....|.|  .|.|:...:.||.......|.|..|||.|..|::|.  |..::.:
  Rat    64 VDVSGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF--TADTFGI 126

  Fly    69 GKGKLLPFITNYVFVCKNCSASGLESFRKSQATISQMCHCAIANMQ-QAASRDGRRQIQFSKDKE 132
            .....|||:|||.|.|..|..||...|.:.||.:.:||..|:||:. |:.::|...:..|||||:
  Rat   127 DTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKD 191

  Fly   133 IIPYIEQYWEAMTTMPRRLTQSWYSTVQRSLVKDVQTLFTYEEHAEHGA--------MYGLFHQD 189
            |||:|::|||.|||..|....:|.:.:.:::.|: :.:|..:||.:.|:        .:||..||
  Rat   192 IIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKE-RDVFLVKEHPDPGSKDPEEDYPKFGLLDQD 255

  Fly   190 LRIIKPNYESMSKSGALRLTDD---------GYTQASLSKNNRQKRKFPGTDSGPTG--KKGRPS 243
            |..|.|.|::..:|.|:..:.:         |....|..|....|||  ..|.|.||  ||.| |
  Rat   256 LSNIGPAYDNQKQSSAVSASGNLNGGATLGGGIAAGSSGKGRGAKRK--QQDGGTTGTTKKAR-S 317

  Fly   244 SDITANVKLPPHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRILVPHS 308
            ..:.:..:|||||||||||||||||||||||||||||..::. |...||||||||.|||..:...
  Rat   318 DPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKL-ELDCWAGKPIPGDLYRACLYER 381

  Fly   309 VLLALHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIEEMPDGAATRLGWGREYG 373
            |||||||||||||||:|||.|.||:||.||||:|.|.:|.||||:|::|||...|.||||.:..|
  Rat   382 VLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLG 446

  Fly   374 NLQAPLGYDKFGYSWRSRKGTKFTESHGKHYSDAYVEGDTLGFLIELPEEA-SLDYLPNTFKDRP 437
            |||||||||||.|||||:|||||.:|.|||||..|.:||.|||.|.|||:. :...||:|:||:.
  Rat   447 NLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKA 511

  Fly   438 LVKFKSHLYYEDKDKITETLKNLHILQGSRIEFFKNGQSQGVAFEDIYAGSYFPAISIHKSATVS 502
            |:||||:||:|:||.:.:..|:|.....|.|.|:|||.:||||::||:.|.||||||::||.|||
  Rat   512 LIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVS 576

  Fly   503 VNFGPAFKYPEVLVEHKAKGMHDRVEELITEQCLADTLY--LTEHDGR 548
            :||||:||||...|.:..  |.|.....:.|..|||.||  .||.|||
  Rat   577 INFGPSFKYPPKDVTYHP--MSDMGWGAVVEHTLADVLYHVETEVDGR 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash2	NP_788735.1	PHD_ash2p_like	36..87	CDD:277058	17/50 (34%)
		SPRY_Ash2	320..510	CDD:293932	115/190 (61%)
Ash2l	XP_006253365.1	PHD_ash2p_like	96..145	CDD:277058	17/50 (34%)
		SPRY_Ash2	393..584	CDD:293932	115/190 (61%)