DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash2 and Ash2l

DIOPT Version :9

Sequence 1:	NP_788735.1	Gene:	ash2 / 42936	FlyBaseID:	FBgn0000139	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_006253365.1	Gene:	Ash2l / 290829	RGDID:	1305632	Length:	629	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	271/568 - (47%)
Similarity:	352/568 - (61%)	Gaps:	34/568 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MDTSSPTESSSEVNFTAE--EDKSQETRSAAGVCYCGKERNLNIVELLCATCSRWVHETCVSYQL 68
            :|.|.....||....|.|  .|.|:...:.||.......|.|..|||.|..|::|.  |..::.:
  Rat    64 VDVSGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF--TADTFGI 126

  Fly    69 GKGKLLPFITNYVFVCKNCSASGLESFRKSQATISQMCHCAIANMQ-QAASRDGRRQIQFSKDKE 132
            .....|||:|||.|.|..|..||...|.:.||.:.:||..|:||:. |:.::|...:..|||||:
  Rat   127 DTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKD 191

  Fly   133 IIPYIEQYWEAMTTMPRRLTQSWYSTVQRSLVKDVQTLFTYEEHAEHGA--------MYGLFHQD 189
            |||:|::|||.|||..|....:|.:.:.:::.|: :.:|..:||.:.|:        .:||..||
  Rat   192 IIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKE-RDVFLVKEHPDPGSKDPEEDYPKFGLLDQD 255

  Fly   190 LRIIKPNYESMSKSGALRLTDD---------GYTQASLSKNNRQKRKFPGTDSGPTG--KKGRPS 243
            |..|.|.|::..:|.|:..:.:         |....|..|....|||  ..|.|.||  ||.| |
  Rat   256 LSNIGPAYDNQKQSSAVSASGNLNGGATLGGGIAAGSSGKGRGAKRK--QQDGGTTGTTKKAR-S 317

  Fly   244 SDITANVKLPPHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRILVPHS 308
            ..:.:..:|||||||||||||||||||||||||||||..::. |...||||||||.|||..:...
  Rat   318 DPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKL-ELDCWAGKPIPGDLYRACLYER 381

  Fly   309 VLLALHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIEEMPDGAATRLGWGREYG 373
            |||||||||||||||:|||.|.||:||.||||:|.|.:|.||||:|::|||...|.||||.:..|
  Rat   382 VLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLG 446

  Fly   374 NLQAPLGYDKFGYSWRSRKGTKFTESHGKHYSDAYVEGDTLGFLIELPEEA-SLDYLPNTFKDRP 437
            |||||||||||.|||||:|||||.:|.|||||..|.:||.|||.|.|||:. :...||:|:||:.
  Rat   447 NLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKA 511

  Fly   438 LVKFKSHLYYEDKDKITETLKNLHILQGSRIEFFKNGQSQGVAFEDIYAGSYFPAISIHKSATVS 502
            |:||||:||:|:||.:.:..|:|.....|.|.|:|||.:||||::||:.|.||||||::||.|||
  Rat   512 LIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVS 576

  Fly   503 VNFGPAFKYPEVLVEHKAKGMHDRVEELITEQCLADTLY--LTEHDGR 548
            :||||:||||...|.:..  |.|.....:.|..|||.||  .||.|||
  Rat   577 INFGPSFKYPPKDVTYHP--MSDMGWGAVVEHTLADVLYHVETEVDGR 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash2	NP_788735.1	PHD_ash2p_like	36..87	CDD:277058	17/50 (34%)
ash2	NP_788735.1	SPRY_Ash2	320..510	CDD:293932	115/190 (61%)
Ash2l	XP_006253365.1	PHD_ash2p_like	96..145	CDD:277058	17/50 (34%)
Ash2l	XP_006253365.1	SPRY_Ash2	393..584	CDD:293932	115/190 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335586
Domainoid	1	1.000	260	1.000	Domainoid score	I1908
eggNOG	1	0.900	-	-		E1_KOG2626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3436
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1399
OMA	1	1.010	-	-		QHG53232
OrthoDB	1	1.010	-	-		D444178at2759
OrthoFinder	1	1.000	-	-		FOG0004969
OrthoInspector	1	1.000	-	-		oto95559
orthoMCL	1	0.900	-	-		OOG6_102272
Panther	1	1.100	-	-	LDO	PTHR10598
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4622
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770