Protein Alignment puf and USP34

DIOPT Version :9

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: NP_055524.3
• Gene: USP34 / 9736
• HGNCID: 20066
• Length: 3546
• Species: Homo sapiens
• Alignment Length: 4097
• Identity: 1541/4097 - (37%)
• Similarity: 2174/4097 - (53%)
• Gaps: 820/4097 - (20%)

  Fly     1 MCEVCADFQNLLELYEVRVASSDLK----FQLLLKSEIETTFNYIQSWPQRQCMCLYRDTKNYDR 61
            |||.|||      |.||....||::    .| |.|......|.||.||.||||:|.:::.|:.:.
Human     1 MCENCAD------LVEVLNEISDVEGGDGLQ-LRKEHTLKIFTYINSWTQRQCLCCFKEYKHLEI 58

  Fly    62 FNLVVQSLICLTVQHLKHIDHLIDNYKRLTASAAQVVAQAQQQREQQRDEASA---QAEAKESSA 123
            ||.||.:||.|                        |:||.|..|:|.....:.   .:..::.|.
Human    59 FNQVVCALINL------------------------VIAQVQVLRDQLCKHCTTINIDSTWQDESN 99

  Fly   124 PAEEP---KKEEPSGSAGEEAQGSGDGPAKKPPVGPCTPPPPQTANPQHKSHLQYTEEP---WIL 182
            .||||   .:|...||.  |.|.|.:..:....:  |.    .|.....||     .:|   |..
Human   100 QAEEPLNIDRECNEGST--ERQKSIEKKSNSTRI--CN----LTEEESSKS-----SDPFSLWST 151

  Fly   183 PEVEKLLVLVSKVFLLNFPLYIAHKHGMHSRLDDLQAEEAHHLALICDLHDNDLPIYLLRNVSLF 247
            .|.||||:.|:|:|.:.||||.|:||..|..::|:..:|::.|...||::|.::|::|||.|.||
Human   152 DEKEKLLLCVAKIFQIQFPLYTAYKHNTHPTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLF 216

  Fly   248 CNSGGFGAMSLCFEH--PD-LPVSTAHSMTAAVSNVKLWLNYHCNTQLFVPLRSRILQYMCKLSD 309
            |...|...|..|||:  |: ||...||:....|||:::||:.....|..:|.|:.:::|:|||||
Human   217 CGKNGLSLMKDCFEYGTPETLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRTYVIRYLCKLSD 281

  Fly   310 QSLRSAATRAMADFVWSSMRDPLDVAVNFDTEGLALAFKYFTSTTLTMRLAGMAQINAHINLFNE 374
            |.||.:|.|.|||.:||::::|||..:.||.|.|.||||||.|.||||||||::||...::.||:
Human   282 QELRQSAARNMADLMWSTVKEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFND 346

  Fly   375 ICTTET-VNEVEL-FGQRIANWLTENHIVQHLFGPNLHVEIVKQAHVLLNFLAVENQISEEDIKL 437
            :|..|: |::.|. ..:.:|:||..|::|:|:||||||:||:||..|:|||||.|.::|.:.|..
Human   347 VCNNESLVSDTETSIAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDC 411

  Fly   438 IWQATQLKHCSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTEQSIYIASALTKQLWTRD- 501
            ||.|.||||||:.|.|:.|||:|||.|.|..||.:|:..::|..||||::|:||.|.|.||...
Human   412 IWAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSALEPSVHTEQTLYLASMLIKALWNNAL 476

  Fly   502 TSRSQMNLMQD--HLLGSNV--------------------------TASSSDSGSIEGSNTEDD- 537
            .:::|::....  .||.:|:                          ::.:||:....||:.|.|
Human   477 AAKAQLSKQSSFASLLNTNIPIGNKKEEEELRRTAPSPWSPAASPQSSDNSDTHQSGGSDIEMDE 541

  Fly   538 -------HV------------GADDSSIASG-GGGGGVGNKS-PIDGVTPCKQARHRRHICDPTT 581
                   ||            |:.|.:..|| .|..|.|:.| ..||   .....:..|......
Human   542 QLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDG---SSNEVNSSHASQSAG 603

  Fly   582 EKGKQISPEDMAKVDLVNKRIVNIID----------NTSSEEELQSRAALELQ----LHRSRKKT 632
            ..|.::..||:|.::.:.:.     |          .:|...:|::| .||.|    |..|:..:
Human   604 SPGSEVQSEDIADIEALKEE-----DEDDDHGHNPPKSSCGTDLRNR-KLESQAGICLGDSQGMS 662

  Fly   633 SNKRRRQKTNKQIILPHELVEIWDGVEDVPSSD-----------EADGEADGDGE---GELLADS 683
            ........|.|.::.         ..|.:||.|           ..|.|.|..||   ..:...|
Human   663 ERNGTSSGTGKDLVF---------NTESLPSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGS 718

  Fly   684 DECSDGATSQLVPDAVLKHLQGEGPFIRAIETN-------------INELLSGAENDGSYSSPMS 735
            .|.....|...:.:.:...|.....||.....:             ::::|| |::....||.:|
Human   719 QESCITRTGDFLGETIGNELFNCRQFIGPQHHHHHHHHHHHHDGHMVDDMLS-ADDVSCSSSQVS 782

  Fly   736 NKSEKNLADFDDEDVSPCEEELAQLVSSRANCSDVPPAFAAAAAAMMVAQSAMALQKSGESNVAA 800
            .|||||:||||.|: |.|||||.|:.|.
Human   783 AKSEKNMADFDGEE-SGCEEELVQINSH------------------------------------- 809

  Fly   801 AAAAVAAAAAATGTAQQTLVAMNRQASVAAAAAVVAAAKAKSDSDVDLMDVVSGGKQHHSPKASQ 865
                    |..|...||.|..:   ||:                   ..:.:|.|...|..:.:.
Human   810 --------AELTSHLQQHLPNL---ASI-------------------YHEHLSQGPVVHKHQFNS 844

  Fly   866 GSSTSGSTPVQPSFKLNDVCQPGNTLLWDLLQDDKIGQLGESLALEAEKALATLLCFSMDRQLRT 930
            .:.|        ...|::||:.|||||||::||:....|.|.|..||||.|.:|:|:..|||:|.
Human   845 NAVT--------DINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIRM 901

  Fly   931 KFIEGCLYNVANNRSVIVSLRLLPKLFASFQQFRPS-DTHSMTMWAERNHRMMQCFFNNIRHYAR 994
            :||||||.|:.|||||::|||||||||.:||||..| |||.:|||||:...||:.||:|:.:|
Human   902 RFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDNLVYY-- 964

  Fly   995 RHAEVLITQNGEQQQQQLGGQLYSHKTQVSVRLQFLSSIFSTVGSPKSFRLTLEQLDALWEWLAH 1059
                :...:.|.|:.     .||||..:|.||||||:.:|||:|||..|||:|||:|.||..|..
Human   965 ----IQTVREGRQKH-----ALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCLVE 1020

  Fly  1060 DPECADCYFSWLQAQAKGGDQHALGIEALQHLYLKKLPELRPEEFSMVALGLFQQLCSFARIAMA 1124
            |.||.|....|...|.:..||||:|:|..:||:|:|:|:|:||..||..|.|||.||:.||:|.:
Human  1021 DSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLARLATS 1085

  Fly  1125 EYDNHSDQISASASAVGMYHLWKIALRAQSNDVSLAAIQYINMYYMGQQLRLEK--EFVSQCMEN 1187
            .||..|     ::...||...|.|||||||.|||.|||||||.||:..:..|||  ||:|:|||:
Human  1086 AYDGCS-----NSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFISKCMES 1145

  Fly  1188 LVQAATALESIDDENALMRVQRGLLLLNTHLDTFRRRYAFHLRRWAIEGKGIGSHSNLKNEGAGP 1252
            |:.|:::||. :..::||.::||||:|.|||:.||||:|:|||:|.|||.||.||....::....
Human  1146 LMIASSSLEQ-ESHSSLMVIERGLLMLKTHLEAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSL 1209

  Fly  1253 PLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESL---------------QTGLAAPVLGL 1302
            |||:|.|.|||.:|..::|:..|.:|||:|||:.|:|:|               |:.......|.
Human  1210 PLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQEFGQSNRKGEFPGG 1274

  Fly  1303 LLSDGPLRIITQGQELTSDYDERSLGDAGFKDNQIVYVSLGGRGARRKESNLEHP-SMLPPPPKE 1366
            |:  ||:|:|:.|.|||:||||::|.:.||||.|:|:||||.....||...::.| |.||||.|:
Human  1275 LM--GPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERKGEGVQLPASCLPPPQKD 1337

  Fly  1367 CLPTVLLLQPKYFEKLFCLMQTLGDMQPQASTVN---------PQHHTKAQLLSRRVWDILAMLP 1422
            .:|.:||||..:...||.|::.|...:|.:..|.         .:.|..|:.||||||::|.:||
Human  1338 NIPMLLLLQEPHLTTLFDLLEMLASFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLP 1402

  Fly  1423 TNPHILDAFKSLVTDLSELEQLDAGGEEEQLATKRKQIKQKFRDLLDPNNLQKFMYSLHIVESLA 1487
            |.|::|.||:: ::|    ||.:.|              ..:::||...:..|.:|:|.|:|:|
Human  1403 TCPNMLMAFQN-ISD----EQSNDG--------------FNWKELLKIKSAHKLLYALEIIEAL- 1447

  Fly  1488 LTSSRRGESNGNVAMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMSKEQLCELEAPLTPTPS 1552
                  |:.|.           |:::.|.|
Human  1448 ------GKPNR-----------RIRRESTG----------------------------------- 1460

  Fly  1553 TGLQDVETEASSSSGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPPSPTPPPPALSVVERGD 1617
             ...|:..::..||    |:|                                       ||...
Human  1461 -SYSDLYPDSDDSS----EDQ---------------------------------------VENSK 1481

  Fly  1618 NKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKEL-ALNEWRHDCLASLLRILWL---------LG 1672
            |.||..||..|||:.|.|||:.|.|:    |||. :...|:.||||.||:::..         |.
Human  1482 NSWSCKFVAAGGLQQLLEIFNSGILE----PKEQESWTVWQLDCLACLLKLICQFAVDPSDLDLA 1542

  Fly  1673 FEELQS----ADAHVLMSRP---------HPFML---QLMEVPQCLTRLSSILNDEVHQQHQASS 1721
            :.::.:    |::|...:.|         |...|   :|.||...|.:.:|::...:...:...:
Human  1543 YHDVFAWSGIAESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDN 1607

  Fly  1722 ANPLVFPYQFQHLRTGFWGRAQLIQFAMNILVSFVHASAEARRLLWAPTGTDHCR-WLQKFILED 1785
            ..|.|...|..|.     .|.::..::|.:|||:.|..:..:..|   ..:||.: ||:|..|..
Human  1608 LAPRVLKAQSDHR-----SRHEVSHYSMWLLVSWAHCCSLVKSSL---ADSDHLQDWLKKLTLLI 1664

  Fly  1786 PEPAVRREICAGLYRICLGNA-------HSYRLLLAPLLHKLI----ALLPLAEQMSSGNQHTQF 1839
            ||.|||.|.|:|||::.|...       .|:.||.|..|.|.:    ||.|:.
Human  1665 PETAVRHESCSGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDAQALKPIR------------ 1717

  Fly  1840 LLSEEGKDP-YGPACRDYFWLLARLVDTLSPEMVAEEH-IDIEMLCESISQSILTREYYELRHG- 1901
             :.:..::| ..|.|::|||||.:|||.:..:..::.. :|::.|...::..|.:||..:.:.|
Human  1718 -IDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGN 1781

  Fly  1902 YQDDGLVGLLNLMSNLIKYDTTFKYTPKALSFIEQLIGFLFDMPSPADRQKPKCKSASSRASAYD 1966
            .:||||.|||.|.::::|:...||::.:...|:..:...||.:||..|||:|||||.||||:|||
Human  1782 VEDDGLTGLLRLATSVVKHKPPFKFSREGQEFLRDIFNLLFLLPSLKDRQQPKCKSHSSRAAAYD 1846

  Fly  1967 LLVELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVGLTNLGATCYMASCVQ 2031
            ||||:.:|...||..:|..::|||... ..||.|||||.::.||||.:|||||||||||:||.:|
Human  1847 LLVEMVKGSVENYRLIHNWVMAQHMQS-HAPYKWDYWPHEDVRAECRFVGLTNLGATCYLASTIQ 1910

  Fly  2032 HLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGE 2096
            .|||:|:||.||.....:...||..||||||:||.||:|||.|:||||.||:.|.||.|||||||
Human  1911 QLYMIPEARQAVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGE 1975

  Fly  2097 QKDMAEFFIDLVSKLEDMTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRN 2161
            ||||.|||.||::|:|:|:|:||:.||.||.|.::||||||||.|||:|||:|||||||||||:|
Human  1976 QKDMTEFFTDLITKIEEMSPELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADMKN 2040

  Fly  2162 LQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNT 2226
            :.|||||||:|||||||||||||.|||||||||||||||||:||.|||||||||||||:||||||
Human  2041 IYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNT 2105

  Fly  2227 HFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYEL 2291
            ||||||||:|..|.|..||.:.     ||::..||.:|.|.|               .|.|||:|
Human  2106 HFSFPLRLDMTPYTEDFLMGKS-----ERKEGFKEVSDHSKD---------------SESYEYDL 2150

  Fly  2292 VGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDS 2356
            :||||||||||||||||||::......:.:.:|:|||||||||||.:|:|:||||||||:|||||
Human  2151 IGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTKTYDS 2215

  Fly  2357 VTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSSEI 2421
            ||:|::|||||||:|||||||:|..||                               |.:..|.
Human  2216 VTDKFMDFSFEKTHSAYMLFYKRMEPE-------------------------------EENGREY 2249

  Fly  2422 KADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDEK 2486
            |.||
Human  2250 KFDV------------------------------------------------------------- 2253

  Fly  2487 PTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLNKELEDWIWQD 2551
                                                                  :.||.:|||.|
Human  2254 ------------------------------------------------------SSELLEWIWHD 2264

  Fly  2552 NRQFLQDRNIFEHTYFNFMWQICGHIPQSLISETDVTCMAAKLSVSFFIETFIHAKEKPTMVPWV 2616
            |.|||||:||||||||.||||:|..||.:|.....|:.|.||||.||.:|||||:||||||:.|:
Human  2265 NMQFLQDKNIFEHTYFGFMWQLCSCIPSTLPDPKAVSLMTAKLSTSFVLETFIHSKEKPTMLQWI 2329

  Fly  2617 ELLTKQFNASQEACEWFLSHMSQEPYWPVQVLIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLE 2681
            ||||||||.||.||||||..|:.:.:||:|:||:||||:||||||||.|||||:||..||||||:
Human  2330 ELLTKQFNNSQAACEWFLDRMADDDWWPMQILIKCPNQIVRQMFQRLCIHVIQRLRPVHAHLYLQ 2394

  Fly  2682 --VETDEDDK----ELIGQASCVTRFIGSLISLLEHGARANLRHLSEYFGLLCEFSRMGDEEAMY 2740
              :|...||.    |.||..||||||:.:|:.::|||.:.:.:||:|||..|.||::||:||:.:
Human  2395 PGMEDGSDDMDTSVEDIGGRSCVTRFVRTLLLIMEHGVKPHSKHLTEYFAFLYEFAKMGEEESQF 2459

  Fly  2741 LLRIGVLKSLVDFYLGHK--QTDSIDISSDNEDNSSEE-----ALSVEKMRPASLDKMIALCASL 2798
            ||.:..:.::|.||:|.|  :...:::.|:.|....||     :|:.||.|||:|:|||||.|.|
Human  2460 LLSLQAISTMVHFYMGTKGPENPQVEVLSEEEGEEEEEEEDILSLAEEKYRPAALEKMIALVALL 2524

  Fly  2799 VERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDGINPHQTKHLIHALCRWDERLATQIIGML 2863
            ||:|| ::..|.||..|.:|:.||||||||:|.|:||||..||.:||.:|||::.|||..|:.||
Human  2525 VEQSR-SERHLTLSQTDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLCRYNNRLAEHIVSML 2588

  Fly  2864 FASVTKHT-ELCAPFFKLLTLLTETQGGPVGLPCFTQLILPRMWDAAEYCPQSVLDWLSLQATKN 2927
            |.|:.|.| |...|||||||:|.|..|||.|:|.|...||.|:|:..||.|...||||::|..:|
Human  2589 FTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRN 2653

  Fly  2928 KIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVALVPSQPFRANFRA----HSQHKLLALNP 2988
            |:||:|:||:.|.|:|:|||||:..|||.:||:|||:|:||..||..||:    |...:.|.|:|
Human  2654 KLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSP 2718

  Fly  2989 HSYRDINSDAQAVLHQVITLLLRLLRPARVYADIGAHGTTKLTAYFNLLSYCMVSKTEKLMASSY 3053
                    |...|||||..:||.||..|::|.|...||||||..||:.::||::|||||||.|:|
Human  2719 --------DTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKLMFSTY 2775

  Fly  3054 MRSLWELFHPRLSEPSVPAHHNKHALLTFWHHSLVDCPENAAQVANCPEITRNIAFNYILADHDD 3118
            ...||.||.|:||||::..:|||.|||:||::...|||||...:...|.:|:|||||||||||||
Human  2776 FMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDD 2840

  Fly  3119 AEIVTYNRSMLPAYYGLLRLCCEQSRALTRQLSQHQNLQWAFKNITPHPTQYAAAVDELFKLMAL 3183
            .::|.:||.|||||||:||||||||.|.||||:.|||:||||||:|||.:||..||:|||.||.|
Human  2841 QDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASHQNIQWAFKNLTPHASQYPGAVEELFNLMQL 2905

  Fly  3184 FATRHPDASEQEKLDVTQFRRAVIVSYTSSLDARVSWSTLISALKILVDNEEDRTMVIFNGGIEM 3248
            |..:.||..|:|..|:.||::..|..|...||.|..|:|||||.:||::::|||.:|:||.|:.:
Human  2906 FIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLESDEDRLLVVFNRGLIL 2970

  Fly  3249 CFEALHTLHSMHHEATACHVAGDLFDLLGEMLLLLATLRTRTDSPAQKKQQQQQQQLEQQLQLQQ 3313
            ..|:.:|||.|:||||||||.|||.:||...|.:|.:.|
Human  2971 MTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTR-------------------------- 3009

  Fly  3314 QQMLQKQQQQSQSQTQTPQSPQQKEKQLQQQMQQHLQLQQLQQMQFQQQHFLRQQHQHSALAKAL 3378
                                             .:||.:.::|...|.|..:...|
Human  3010 ---------------------------------PYLQRKDVKQALIQWQERIEFAH--------- 3032

  Fly  3379 PDAVKRLATLLNTFNSPEISRMALEVLKELVRNPSLETISILAPILINCHLSV--ANAPNAIGPL 3441
                 :|.||||:::.||:....::||||||.....:.:..|.|.|.:.|.:.  :|.|.:   |
Human  3033 -----KLLTLLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMS---L 3089

  Fly  3442 GPYFP-RRGAKHTPWPLGAKNSPRPPRPMVQMCI--ALAELTPRGLDADYDVQVESFYRPYHDFI 3503
            ||||| |...|    .:|.|::.|||||.:.||:  .:.| |.:|.|..||..:..::..||.||
Human  3090 GPYFPCRENIK----LIGGKSNIRPPRPELNMCLLPTMVE-TSKGKDDVYDRMLLDYFFSYHQFI 3149

  Fly  3504 DVMMRMCVNTGTLNDTLVKLQCLVAIESTPLHFTYFPKFWVGI--HNNALTHKYVELLVKNQLLV 3566
            .::.|:.:|.....:|||||..|||.|..|||...|||.|..:  ..:|::...::||.::.:..
Human  3150 HLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFA 3214

  Fly  3567 EYLHNVLRDERSMLKDACVREFLELYYHKVAAQL----PVARMIYT-----INYGMHSKDDID-- 3620
            ||:..:|.|||:.|.:..|..|:..:..||.:|:    ..|.:|.|     |:...:.:.|..
Human  3215 EYIKCILMDERTFLNNNIVYTFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNR 3279

  Fly  3621 --------ELCGDLFAIRIIAQATGVPASVRKELRGSLRALQNKSERFRKESERDPFPNKKQKRD 3677
                    .|.|||.|:.::. :...|..:...|..:|:.|.:|.....:  :|:..  ::|:..
Human  3280 VEISKASASLNGDLRALALLL-SVHTPKQLNPALIPTLQELLSKCRTCLQ--QRNSL--QEQEAK 3339

  Fly  3678 SQKIKEKEHPQPESEKETSTENDKPSDVSMESSGNAEQATDSTKPPTPAGSDDEQMDKTSV---- 3738
            .:|.|:.|...|...:..|::.:...|     |..::..|::.:..||..:.|.:...:|:
Human  3340 ERKTKDDEGATPIKRRRVSSDEEHTVD-----SCISDMKTETREVLTPTSTSDNETRDSSIIDPG 3399

  Fly  3739 -----PSSDDETELEDELQPTPKRNKKASNKKT--AQDRVNEERE-----------KRLITLITM 3785
                 ||.::.:..|..::.....::..||.::  |:::.|..|.           .:..||...
Human  3400 TEQDLPSPENSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEE 3464

  Fly  3786 ESYI--QSIFAILKRDASVPSSGATKEPSEEPCGEASTSAAAAVKLSRPKGACTPPEPITDVNDT 3848
            ||..  .||.|:|...|.:.|......||::|      ..|.::.....:|..:..:. .|:.||
Human  3465 ESEFPSTSISAVLSDLADLRSCDGQALPSQDP------EVALSLSCGHSRGLFSHMQQ-HDILDT 3522

  Fly  3849 RC 3850
            .|
Human  3523 LC 3524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	246/368 (67%)
		UCH	2014..2377	CDD:278850	243/362 (67%)
		DUF3517	2723..>2877	CDD:288853	75/161 (47%)
USP34	NP_055524.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..535		2/32 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	550..679		27/146 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1459..1478		6/97 (6%)
		peptidase_C19C	1892..2241	CDD:239124	246/368 (67%)
		UCH	1894..2236	CDD:278850	243/361 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3331..3443		20/118 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1059	1.000	Domainoid score	I24
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40978
Inparanoid	1	1.050	2540	1.000	Inparanoid score	I30
Isobase	1	0.950	-	0	Normalized mean entropy	S7836
OMA	1	1.010	-	-		QHG45595
OrthoDB	1	1.010	-	-		D12667at33208
OrthoFinder	1	1.000	-	-		FOG0008147
OrthoInspector	1	1.000	-	-		oto89933
orthoMCL	1	0.900	-	-		OOG6_105892
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11966
SonicParanoid	1	1.000	-	-		X6108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.910