DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puf and USP48

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	NP_115612.4	Gene:	USP48 / 84196	HGNCID:	18533	Length:	1035	Species:	Homo sapiens

Alignment Length:	615	Identity:	154/615 - (25%)
Similarity:	238/615 - (38%)	Gaps:	173/615 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1948 ADRQKPKCKSASSRASAYDLLVELC------RGCATNYAYLHGRLLAQHKSGPKQPYPWDYW--- 2003
            |:..:|:..|.....:||.:.:|.|      |.|..|...|.|  :.:|           .|
Human    15 AETVRPEEVSQEHIETAYRIWLEPCIRGVCRRNCKGNPNCLVG--IGEH-----------IWLGE 66

  Fly  2004 -----------PRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAA------ 2051
                       |..|.|.:..:|||||||||||:.:.:|..::..:.|.|:...|...:
Human    67 IDENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGD 131

  Fly  2052 -----RKHGP-TLLE-LQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVS 2109
                 :.:.| |:.| ||.:||.|..|.|:..:|..|.:...:|     ||:|:|..||....:|
Human   132 GIQEEKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLD-----TGQQQDAQEFSKLFMS 191

  Fly  2110 KLED-----MTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEV 2169
            .|||     ..||::::|::.|||..:...|...||..|:....||.:...:...:.|.:.:.|.
Human   192 LLEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDCISEF 256

  Fly  2170 TVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRL 2234
            ..::.|||||.|.|..|..|..|.::.....||..|....||:.|:..|..|:|:||:..|...|
Human   257 LKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEIL 321

  Fly  2235 NMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG 2299
            :|..|||                 .|.|:                       |.|||..|.:|.|
Human   322 DMEPYVE-----------------HKGGS-----------------------YVYELSAVLIHRG 346

  Fly  2300 -TADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPS--QIAAECFGGEMTSKTYDSVTEKY 2361
             :|..|||.:.:|:...      ..|:.|||.:::..:..  |:..|    |..::...|.|.|
Human   347 VSAYSGHYIAHVKDPQS------GEWYKFNDEDIEKMEGKKLQLGIE----EDLAEPSKSQTRK- 400

  Fly  2362 LDFSFEK-------TNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSS 2419
                 .|       :.:||||.|..:..|             .|:.||:..:..:|....:.|..
Human   401 -----PKCGKGTHCSRNAYMLVYRLQTQE-------------KPNTTVQVPAFLQELVDRDNSKF 447

  Fly  2420 EIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETD 2484
            |     :..:|:.|..|:                  :.||.|....|.|::.::...|.|
Human   448 E-----EWCIEMAEMRKQ------------------SVDKGKAKHEEVKELYQRLPAGAE----- 484

  Fly  2485 EKPTEMTTVSTE------EEKQPTANCDNH 2508
              |.|.  ||.|      :|..||...|||
Human   485 --PYEF--VSLEWLQKWLDESTPTKPIDNH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	109/396 (28%)
		UCH	2014..2377	CDD:278850	108/390 (28%)
		DUF3517	2723..>2877	CDD:288853
USP48	NP_115612.4	UCH	89..418	CDD:278850	108/389 (28%)
		Peptidase_C19L	90..419	CDD:239133	107/389 (28%)
		DUSP	484..554	CDD:283896	12/36 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..640
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..919
		USP48_C	929..1035	CDD:176390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810