Protein Alignment puf and USP48

DIOPT Version :10

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: NP_115612.4
• Gene: USP48 / 84196
• HGNCID: 18533
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 154/615 - (25%)
• Similarity: 238/615 - (38%)
• Gaps: 173/615 - (28%)

  Fly  1948 ADRQKPKCKSASSRASAYDLLVELC------RGCATNYAYLHGRLLAQHKSGPKQPYPWDYW--- 2003
            |:..:|:..|.....:||.:.:|.|      |.|..|...|.|  :.:|           .|
Human    15 AETVRPEEVSQEHIETAYRIWLEPCIRGVCRRNCKGNPNCLVG--IGEH-----------IWLGE 66

  Fly  2004 -----------PRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAA------ 2051
                       |..|.|.:..:|||||||||||:.:.:|..::..:.|.|:...|...:
Human    67 IDENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGD 131

  Fly  2052 -----RKHGP-TLLE-LQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVS 2109
                 :.:.| |:.| ||.:||.|..|.|:..:|..|.:...:|     ||:|:|..||....:|
Human   132 GIQEEKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLD-----TGQQQDAQEFSKLFMS 191

  Fly  2110 KLED-----MTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEV 2169
            .|||     ..||::::|::.|||..:...|...||..|:....||.:...:...:.|.:.:.|.
Human   192 LLEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDCISEF 256

  Fly  2170 TVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRL 2234
            ..::.|||||.|.|..|..|..|.::.....||..|....||:.|:..|..|:|:||:..|...|
Human   257 LKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEIL 321

  Fly  2235 NMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG 2299
            :|..|||                 .|.|:                       |.|||..|.:|.|
Human   322 DMEPYVE-----------------HKGGS-----------------------YVYELSAVLIHRG 346

  Fly  2300 -TADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPS--QIAAECFGGEMTSKTYDSVTEKY 2361
             :|..|||.:.:|:...      ..|:.|||.:::..:..  |:..|    |..::...|.|.|
Human   347 VSAYSGHYIAHVKDPQS------GEWYKFNDEDIEKMEGKKLQLGIE----EDLAEPSKSQTRK- 400

  Fly  2362 LDFSFEK-------TNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSS 2419
                 .|       :.:||||.|..:..|             .|:.||:..:..:|....:.|..
Human   401 -----PKCGKGTHCSRNAYMLVYRLQTQE-------------KPNTTVQVPAFLQELVDRDNSKF 447

  Fly  2420 EIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETD 2484
            |     :..:|:.|..|:                  :.||.|....|.|::.::...|.|
Human   448 E-----EWCIEMAEMRKQ------------------SVDKGKAKHEEVKELYQRLPAGAE----- 484

  Fly  2485 EKPTEMTTVSTE------EEKQPTANCDNH 2508
              |.|.  ||.|      :|..||...|||
Human   485 --PYEF--VSLEWLQKWLDESTPTKPIDNH 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	109/396 (28%)
		DUF3517	2648..>2884	CDD:463438
		MDN1	<3661..>3887	CDD:444083
USP48	NP_115612.4	Peptidase_C19L	90..419	CDD:239133	107/389 (28%)
		DUSP	484..554	CDD:399383	12/36 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	612..640
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	879..919
		Ubl_USP48	939..1034	CDD:340493