Protein Alignment puf and USP9Y

DIOPT Version :9

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: XP_016885567.1
• Gene: USP9Y / 8287
• HGNCID: 12633
• Length: 2560
• Species: Homo sapiens
• Alignment Length: 3159
• Identity: 568/3159 - (17%)
• Similarity: 998/3159 - (31%)
• Gaps: 1194/3159 - (37%)

  Fly    98 VAQAQQQREQQRDEASAQAEAKESSAPAEEPKKEEPSGSAGEEAQGSGDGPAKKPPVGPCTPPPP 162
            |...|.|...|:::.|:...:.|:|.....|           |.||.||.|
Human    19 VLDGQSQHLFQQNQTSSPDSSNENSVATPPP-----------EEQGQGDAP-------------- 58

  Fly   163 QTANPQHKSHLQYTEEP------------------WILP-----EVEKLL--------------- 189
                |||:.     |||                  |::|     |:|.||
Human    59 ----PQHED-----EEPAFPHTELANLDDMINRPRWVVPVLPKGELEVLLEAAIDLSVKGLDVKS 114

  Fly   190 ----------VLVSKVFLLNFPLYIAHKHGMHSRLDDLQAEEAHHLALIC--DLHDNDLPIYLLR 242
                      :.:|...:|........|..:|..:    ....|.|..:|  .|..:..|:..|.
Human   115 EACQRFFRDGLTISFTKILMDEAVSGWKFEIHRCI----INNTHRLVELCVAKLSQDWFPLLELL 175

  Fly   243 NVSL-----FCNSGGFGAMSLCFEHPDLPVSTAHSMTAAVSNVKLW------------------- 283
            .::|     |....|.....|...:..||.....:.::...:.|.|
Human   176 AMALNPHCKFHIYNGTRPCELISSNAQLPEDELFARSSDPRSPKGWLVDLINKFGTLNGFQILHD 240

  Fly   284 --------------------------LNYHCNTQLFVPLRSRILQYMCKLSDQSL-RSAATRAMA 321
                                      |:.|...:.|:|:...:...:..|:|:.| :.|...|..
Human   241 RFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYFIPVIEIVPHLLENLTDEELKKEAKNEAKN 305

  Fly   322 DFVWSSMRDPLDVAVNFDTEGLALAFKYFTSTTLTMRLAGMAQINAHINLFNEICTTETVNEVE- 385
            |.:...::...::|.....:...:.........:.:||..::..|..:|..|||  .:.::.|.
Human   306 DALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRLLQISSFNGKMNALNEI--NKVISSVSY 368

  Fly   386 -------------LFGQRIANWLTENHIVQHLFGPNLH-VEIVKQAHVLLNFLAVENQISEEDIK 436
                         |..:|:|.|:.:|:|:..:...:|| .:.|::...:|.|:..|..::.:|:.
Human   369 YTHRHSNPEEEEWLTAERMAEWIQQNNILSIVLQDSLHQPQYVEKLEKILRFVIKEKALTLQDLD 433

  Fly   437 LIWQATQLKH--CSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTEQSIYIASALTKQLWT 499
            .||.|...||  ..|.:.|:|..|..:.:|....||:...                    |..||
Human   434 NIWAAQAGKHEAIVKNVHDLLAKLAWDFSPGQLDHLFDCF--------------------KASWT 478

  Fly   500 RDTSRSQMNLMQDHLLGSNVTASSSDSGSIEGSNTEDDHVGADDSSIASGGGGGGVGNKSPIDGV 564
            ..:.:.:..|::                 :.....|||.                       |||
Human   479 NASKKQREKLLE-----------------LIRRLAEDDK-----------------------DGV 503

  Fly   565 TPCKQARHRRHICDPTTEKGKQISPEDMAKVDLVNKRIVNIIDNTSSEEELQSRAALELQLHRSR 629
                                       ||      .:::|::.|.:..::
Human   504 ---------------------------MA------HKVLNLLWNLAQSDD--------------- 520

  Fly   630 KKTSNKRRRQKTNKQIILPHELVEIWDGVEDVPSSDEADGEADGDGEGELLADSDECSDGATSQL 694
                             :|.:::::                        .|:...:..|.:.||
Human   521 -----------------VPVDIMDL------------------------ALSAHIKILDYSCSQ- 543

  Fly   695 VPDAVLKHLQGEGPFIRAIETNINELLSGAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQ 759
              |...:.:|....||..:.||                              |:.|.|..:::.:
Human   544 --DRDAQKIQWIDHFIEELRTN------------------------------DKWVIPALKQIRE 576

  Fly   760 LVSSRANCSDVPPAFAAAAAAMMVAQSAMALQKSGESNVAAAAAAVAAAAAATGTAQQTLVAMNR 824
            :      ||                                          ..|.|.|.|
Human   577 I------CS------------------------------------------LFGEASQNL----- 588

  Fly   825 QASVAAAAAVVAAAKAKSDSDVDLMDVVSGGKQHHSPKASQGSSTSGSTPVQPSFKLNDVCQPGN 889
                                                 .:|..|.|..|..:
Human   589 -------------------------------------SSSYFSQTQRSPHI-------------- 602

  Fly   890 TLLWDLLQDDKIGQLGESLALEAEKALATLLCFSMDRQLRTKFIEGCLYNVANNRSVIVSLRLLP 954
                 ..:.|.|.|      |:...||.||                    ||.|
Human   603 -----FYRHDLINQ------LQQNHALVTL--------------------VAEN----------- 625

  Fly   955 KLFASFQQFRPSDTHSMTMWAERNHRMMQCFFNNIRHYARRHAEVLITQNGEQQQQQLGGQLYSH 1019
                                       :..:.|:||.||..|      ::.:.|..:||.: |||
Human   626 ---------------------------LATYMNSIRLYAGDH------EDYDPQTVRLGSR-YSH 656

  Fly  1020 KTQVSVRLQFLSSIFSTVGSPKSFRLTL--EQLDALWEWLAH------DPECADCYFSWLQAQAK 1076
            ..:|..||.||..:.      |..:|.|  .|...:|:.||.      |.|....::|.|.
Human   657 VQEVQERLNFLRFLL------KDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLM---- 711

  Fly  1077 GGDQHALGIEALQHLYLKKLPELRPEEFSMVALGLFQQL-----CSFARIAMAEYDNHSDQISAS 1136
             ||:..|..:..:..:...:.:|.|...:...:..|::.     |...::.........|.:
Human   712 -GDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCRERKLIAKRRSYMMDDL--- 772

  Fly  1137 ASAVGMYHLWKIALRAQSNDVSLAAIQYINMYY--MGQQLR-----LEKEFVSQCMENLVQAATA 1194
             ..:|:.:||::.::: |::::..||..:...|  :|.:|:     :.::|:..|.:.|..:...
Human   773 -ELIGLDYLWRVVIQS-SDEIANRAIDLLKEIYTNLGPRLKANQVVIHEDFIQSCFDRLKASYDT 835

  Fly  1195 LESID-DENAL-------MRVQRGLLLLNTHL-----DTFRRRYAFHLRRWAIEGKGIGSHSNLK 1246
            |...| |:|::       :|:.|.|.::..::     |..:.|....:.| |..||.:.......
Human   836 LCVFDGDKNSINCARQEAIRMVRVLTVIKEYINECDSDYHKERMILPMSR-AFRGKHLSLIVRFP 899

  Fly  1247 NEGAGPPLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESLQTGLAAPVLGLLLSDGPLRI 1311
            |:|.                   |:...|:.:.....:......:...:.|.|     :...:.:
Human   900 NQGR-------------------QVDELDIWSHTNDTIGSVRRCIVNRIKANV-----AHKKIEL 940

  Fly  1312 ITQGQELTSDYDERSLGDAGFKDNQIVYVSL-------------------GGRGARRKESNLEHP 1357
            ...|:.:.|:.|.:.:|....||..::...|                   ...|..|...| :.|
Human   941 FVGGELIDSEDDRKLIGQLNLKDKSLITAKLTQINFNMPSSPDSSSDSSTASPGNHRNHYN-DGP 1004

  Fly  1358 SMLPPPPKECLPTVLL-LQPKYFEKLFCLMQTLGDMQPQASTVN-PQHHTKAQLLSRRVWDILAM 1420
            ::   ..:.|||.|:: :.|:|...|:    .:.|:   .|.:| |.....|::|       :.:
Human  1005 NL---EVESCLPGVIMSVHPRYISFLW----QVADL---GSNLNMPPLRDGARVL-------MKL 1052

  Fly  1421 LPTNPHILDAFKSLVTD---LSE------LEQLDAGGEEEQLATKRKQIKQKFRDLLDPNNLQKF 1476
            :|.:...::..:::..|   |.|      |:.|..|....|:.                 .|.:.
Human  1053 MPPDRTAVEKLRAVCLDHAKLGEGKLSPPLDSLFFGPSASQVL-----------------YLTEV 1100

  Fly  1477 MYSLHIVESLALTSSRRGESNGNVAMGNTPEQVRVKKS-------SMGRRRNSNEQPPPPPPEVK 1534
            :|:|.:...:.||.            |::..||...||       ||..|.|.       .|...
Human  1101 VYALLMPAGVPLTD------------GSSDFQVHFLKSGGLPLVLSMLIRNNF-------LPNTD 1146

  Fly  1535 MSKEQLCELE----APLTPTPSTGLQDVETEASSS----SGGDKENQPKQHSKRQKKGETFEQEK 1591
            |...:...|.    |.|..| :.|...|...|.:.    .|.|...|..|        .|.:|..
Human  1147 METRRGAYLNALKIAKLLLT-AIGYGHVRAVAEACQPVVDGTDPITQINQ--------VTHDQAV 1202

  Fly  1592 ERPVGCSTPPSPTPPPPALSVVERGDNKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKELALNEW 1656
            .......:.|:|:                ||..::...:....||.:|.    |.:..::.:
Human  1203 VLQSALQSIPNPS----------------SECVLRNESILLAQEISNEA----SRYMPDICV--- 1244

  Fly  1657 RHDCLASLLRILWLLGFEELQSADAHVLMSRPHPFMLQLMEVPQCLTRLSSILNDEVHQQH---Q 1718
                :.::.:|:|      ..:..|..|:..|:.   ::.::.|..|..|:.|  ||..:.   :
Human  1245 ----IRAIQKIIW------ASACGALGLVFSPNE---EITKIYQMTTNGSNKL--EVEDEQVCCE 1294

  Fly  1719 ASSANPLVFPYQFQHLRTGFWGRAQLIQFAMNILVSFVHASAEARRLLWAPTGTDHCRWLQKFI- 1782
            |.....|.|               .|:..|::.|         ::...|           |.||
Human  1295 ALEVMTLCF---------------ALLPTALDAL---------SKEKAW-----------QTFII 1324

  Fly  1783 ---LEDPEPAVRR-------EICAGLYRICLGNAHSYRLLLAPLLHKLIALLPLAEQMSSGNQHT 1837
               |..|...||:       .:|.   |.|:|:        .|||..:..|..:....:
Human  1325 DLLLHCPSKTVRQLAQEQFFLMCT---RCCMGH--------RPLLFFITLLFTILGSTA------ 1372

  Fly  1838 QFLLSEEGKDPYGPACRDYFWLLARL--------VDTLSPEMVAEEHID-IEMLCESISQSILTR 1893
                .|:||  |.   .|||.||..|        ::..:.|::....|| ::.:.:::..:..|
Human  1373 ----REKGK--YS---GDYFTLLRHLLNYAYNGNINIPNAEVLLVSEIDWLKRIRDNVKNTGET- 1427

  Fly  1894 EYYELRHGYQDDGLVGLLNLMSNLIKYDTT-----FKYTPKALSFIEQLI-GFLFDMPS------ 1946
                   |.::..|.|.|.:...|:.:.|:     |.......:.|::|| .|:|....
Human  1428 -------GVEEPILEGHLGVTKELLAFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQYL 1485

  Fly  1947 -----PADRQKPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGP-----KQPYPWD 2001
                 ||::..|.|.|..:..:.::|||.|..||..|...:...|...:..|.     :....|:
Human  1486 RSGELPAEQAIPVCSSPVTINAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWE 1550

  Fly  2002 YWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGP---------- 2056
            |.|....|...|:|||.|.||||||.|.:|.|||:|..|.::|.:....:..|..
Human  1551 YLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSE 1615

  Fly  2057 ----------------------------------TLLELQRMFAYLLESERKSYNPRSFCRVYQM 2087
                                              .|..||.:|.:|..|:.:.|.||.|.:.:::
Human  1616 SNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFRL 1680

  Fly  2088 DHQPLNTGEQKDMAEFFIDLVSKLEDMTPDLKH--LVKRLFCGSLSNNVVSLDCGHVSRTAEDFY 2150
            ..:|:|..||.|..|||..||..|::....|.|  ::.::..||.::..:...|.|.....|.|.
Human  1681 WGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGCPHRYECEESFT 1745

  Fly  2151 TVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFN 2215
            |:...:.:.:||.:||::....|.|||.|.|.|.:|.|||...||...||||::|.....|:.::
Human  1746 TLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLKRFDYD 1810

  Fly  2216 MVTMLKEKVNTHFSFPLRLNMCHYV---EKTLMPQQYKEERER-RQKEKEGADGSGDGNDNEKAE 2276
            .......|.|.:|.||..|:|..|.   ...|.......|.|. .|||:         :|||.|.
Human  1811 WERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELIEQKEQ---------SDNETAG 1866

  Fly  2277 ATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEV---KPFDPS 2338
            .|         :|.||||.||:|.|.||||||:|.:|......| :.|:.|:|.:|   |..|..
Human  1867 GT---------KYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQT-DHWYKFDDGDVTECKMDDDE 1921

  Fly  2339 QIAAECFGGEMTSKTYDSVTEKYLDFSFEKTN---SAYMLFYERRLPEHLQRRHSELLVTPTPSP 2400
            ::..:|||||...:.:|.:.::   .|:.:..   :||:||||:
Human  1922 EMKNQCFGGEYMGEVFDHMMKR---MSYRRQKRWWNAYILFYEQ--------------------- 1962

  Fly  2401 TVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEP 2465
                                    :|:   ::|.|
Human  1963 ------------------------MDM---IDEDD------------------------------ 1970

  Fly  2466 EEKKIEKQSREGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAA 2530
                                   ||....:|
Human  1971 -----------------------EMIRYISE---------------------------------- 1978

  Fly  2531 QKLQLFRP---LLNKELEDWIWQDNRQFLQDRNIFEHTYFNFMWQI--CGHI-------PQSLIS 2583
              |.:.||   :::..:|..:.:.|.:|:.:|..:...||.|:.::  |..:       ...|:.
Human  1979 --LTIARPHQIIMSPAIERSVRKQNVKFMHNRLQYSLEYFQFVKKLLTCNGVYLNPAPGQDYLLP 2041

  Fly  2584 ET-DVTCMAAKLSVSFFIETFIHAKE--KPTMVPWVELLTKQFNASQEACEWF-------LSHMS 2638
            |. ::|.::.:|:..|...|..|.|:  :.....|.:.|......|:....||       :|:..
Human  2042 EAEEITMISIQLAARFLFTTGFHTKKIVRGPASDWYDALCVLLRHSKNVRFWFTHNVLFNVSNRF 2106

  Fly  2639 QEPYWPVQVLIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQASCVTRFIG 2703
            .|      .|::||:..||..|.:|::.:        ||..|:            ..||.:.|..
Human  2107 SE------YLLECPSAEVRGAFAKLIVFI--------AHFSLQ------------DGSCPSPFAS 2145

  Fly  2704 --------SLISLLEHGARANL-----------RHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKS 2749
                    ..:||.:|..||.|           .||.:||.|...::.:|..|...||::.|..:
Human  2146 PGPSSQACDNLSLSDHLLRATLNLLRREVSEHGHHLQQYFNLFVMYANLGVAEKTQLLKLNVPAT 2210

  Fly  2750 LVDFYLGHKQTDSIDISSDNEDNSSEEALSVEKMRPASLDKMIALCASLVERSRGADFRLRLSPK 2814
            .:...|.......|                  |.:.|.|.|:.::.:.|:.       ...:|..
Human  2211 FMLVSLDEGPGPPI------------------KYQYAELGKLYSVVSQLIR-------CCNVSST 2250

  Fly  2815 DFSAIAGGKGFP----------------------------FLYQQIKDGINPHQTKHLIHALCRW 2851
            ..|:|.|....|                            ::.:.|:|..|...|..|:. .|.|
Human  2251 MQSSINGNPPLPNPFGDLNLSQPIMPIQQNVLDILFVRTSYVKKIIEDCSNSEDTIKLLR-FCSW 2314

  Fly  2852 D--ERLATQIIGMLFASVTKHTELCAPFFKLL--TLLTE 2886
            :  :..:|.:..:|:.....:|....|:..||  .||.|
Human  2315 ENPQFSSTVLSELLWQVAYSYTYELRPYLDLLFQILLIE 2353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	129/424 (30%)
		UCH	2014..2377	CDD:278850	125/418 (30%)
		DUF3517	2723..>2877	CDD:288853	30/183 (16%)
USP9Y	XP_016885567.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920