DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puf and Usp38

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	NP_081830.2	Gene:	Usp38 / 74841	MGIID:	1922091	Length:	1042	Species:	Mus musculus

Alignment Length:	1117	Identity:	213/1117 - (19%)
Similarity:	360/1117 - (32%)	Gaps:	425/1117 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1637 FSEGQLQQSAHP---KELALNEWRHDCL------ASLLRILWLLGFEELQSADAHVLMSRPHPFM 1692
            |..|.|||..|.   |::|:.::.|:.|      .|:|.:..||..|.|:     ::..||.|.:
Mouse    84 FVLGLLQQGYHSVDRKDVAILDYIHNGLKLIMSCPSVLDLFSLLQVEVLR-----MVCERPEPVL 143

  Fly  1693 LQLMEVPQCLTRLSSILNDEVHQQHQASSANPLVFPYQFQHLRTGFWGRAQLIQFAMNILVSFVH 1757
                    | .|||.:|.|.|    |......|...:..|.:||  .|..|.:......|..:|.
Mouse   144 --------C-ARLSDLLTDFV----QCVPKGKLSVTFCQQLVRT--IGHFQCVSTQEKELREYVS 193

  Fly  1758 ASAEARRLL---WAPTGTDHCRWLQKFILEDPEPAVRREICAGLYRICLGNAHSYRLLLAPLLHK 1819
            ...:...||   |                 ..||:........::........|:...:|  |..
Mouse   194 QVTKVSTLLQNIW-----------------KAEPSTLLPSLQEVFASISSTDASFEPSVA--LAS 239

  Fly  1820 LIALLPLAEQMSSGNQHTQFLLSEEGKDP-------YGPACRDYFWL---LARLVDT----LSPE 1870
            |:..:||        |....|:.....||       ....||...||   ||:.|||    |...
Mouse   240 LVQHIPL--------QMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKG 296

  Fly  1871 MVAEEH----IDIEML------------------CESISQSILTREY------------YELRHG 1901
            :.|.:.    ||:.:|                  ...:|..:|:.::            ..|.|.
Mouse   297 LAAVQKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHVIVPHIVNLVHS 361

  Fly  1902 YQDDG-------LVGLLNLMSNLIKYDTTFKYTPKALSFIEQLIGFLFDMPSPADRQKPKCKSAS 1959
            ::.||       ||.|..|:..::.:.:.|.      ...|.::..:.|.|.|::.:.....:.|
Mouse   362 FRSDGLPSSTAFLVQLTELVHCMMYHYSGFP------DLYEPILEAVKDFPKPSEEKIKLILNQS 420

  Fly  1960 SRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVGLTNLGATC 2024
            :..|..:.|.    .|.:                           |..|::|.|..||.|||.||
Mouse   421 AWTSQSNALA----SCLS---------------------------RLSGKSETGKTGLINLGNTC 454

  Fly  2025 YMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSF-------- 2081
            ||.|.:|.|:|..:.|..||.:..|....   .:.:||.:||:|..::|::|.||.|
Mouse   455 YMNSVLQALFMATEFRRQVLSLNLNGCNS---LMKKLQHLFAFLAHTQREAYAPRIFFEASRPPW 516

  Fly  2082 --------CRVY-----------------QMDHQPLNTGEQKDMAEFFI-DLVSKLEDMT----- 2115
                    |..|                 |..|:|   .|..|.||..: ::.||:...|
Mouse   517 FTPRSQQDCSEYLRFLLDRLHEEEKILRVQSSHKP---SEGLDCAETCLQEVTSKVAVPTESPGT 578

  Fly  2116 -PDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVR---CQVADMRNLQ------------- 2163
             ...|.|::::|.|.|..::..|:||..|...|.|..:.   |....:.:|.
Mouse   579 GDSEKTLIEKMFGGKLRTHICCLNCGSTSHKVEAFTDLSLAFCPSPSVEDLSFQDTASLPSAQDD 643

  Fly  2164 ----------------------------------------------------------------- 2163

Mouse   644 GLMQTSVADPEEEPVVYNPATAAFVCDSVVNQRVLGSPPVEFHCAESSSVPEESAKILISKDVPQ 708

  Fly  2164 ----ESLDEVT-------VKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMV 2217
                ||...||       ..:.|.|:|.|.|..|.....|||.....:.|:.|....:|::::..
Mouse   709 NPGGESTTSVTDLLNYFLAPEVLTGENQYYCESCASLQNAEKTMQITEEPEYLILTLLRFSYDQK 773

  Fly  2218 TMLKEKVNTHFSFPLRLNMCHYVEKTL----MPQQYKEERERRQKEKEGADGSGDGNDN----EK 2274
            ..::.|:..:.|.||.|.:  .|::|.    :.|.:..:.:           ..|.|:|    .|
Mouse   774 YHVRRKILDNVSLPLVLEL--PVKRTASFSSLSQSWSVDVD-----------FTDINENLPKKLK 825

  Fly  2275 AEATLDDDIEECYEYELVGVTVHTG-TADGGHYYSFIKE--RTKTSY------------------ 2318
            ...|.:....:...|.|..|.||:| :::.|||||:.:.  .|::||
Mouse   826 PSGTEEAFCPKLVPYLLSSVVVHSGVSSESGHYYSYARNITGTESSYQMCPQSESLALAPSQSCL 890

  Fly  2319 -----------------HTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSF 2366
                             ...:.||||||:.|                 |..::.||.:  :...|
Mouse   891 LGVESPNTVIEQDLENKEMSQEWFLFNDSRV-----------------TFTSFQSVQK--ITSRF 936

  Fly  2367 EKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSSEIKADVDVEVEV 2431
            .| ::||:|.|::      |.|.:.:
Mouse   937 PK-DTAYVLLYKK------QSRANGI--------------------------------------- 955

  Fly  2432 EEKDKEKPAQTDTESKETPAKEEIADDKSKQDE--PEEKKIEKQSREGEEKSET-DEKPTEMTTV 2493
               |.:.||.....:.:.|.::|:.|..:|.::  .:|:::..::|..:..|.: ..:|...
Mouse   956 ---DSDNPASGVWANGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGF--- 1014

  Fly  2494 STEEEKQPTANC 2505
               ::..|..:|
Mouse  1015 ---DDNDPPGSC 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	112/546 (21%)
		UCH	2014..2377	CDD:278850	110/540 (20%)
		DUF3517	2723..>2877	CDD:288853
Usp38	NP_081830.2	UCH	445..946	CDD:278850	110/539 (20%)
Usp38	NP_081830.2	Peptidase_C19H	446..947	CDD:239129	110/539 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910