Protein Alignment puf and USP35

DIOPT Version :9

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: NP_065849.1
• Gene: USP35 / 57558
• HGNCID: 20061
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 1140
• Identity: 212/1140 - (18%)
• Similarity: 348/1140 - (30%)
• Gaps: 459/1140 - (40%)

  Fly  1625 VKCGGLRHLYEIFSEGQLQQSAHPKELALNEWRHDCLASLLRI---LWLLGFEELQSADAHVLMS 1686
            ||.|.:|.:        |:.:..|.|      |..||| ||.:   |::.|.|||
Human    17 VKQGLVRRV--------LEAARQPLE------REQCLA-LLALGARLYVGGAEEL---------- 56

  Fly  1687 RPHPFMLQLMEVPQCLTRLSSILNDEVHQQHQASSANPLVFPYQFQHLR--------TGFWGRAQ 1743
             |.....||:                    |.|...:|.||...|...|        .|..|...
Human    57 -PRRVGCQLL--------------------HVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRA 100

  Fly  1744 L--IQFAMNILVS-------FVHASAEARRLLWAPTGTDHCRWLQKFILED----PEPAVRREIC 1795
            |  :|..:.:|..       |.....|..|.:....|...|..:.:.:...    |:...|...|
Human   101 LACVQLGLQLLPEGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPHRLLFC 165

  Fly  1796 AGLYRICLG-----------------NAHSYRLLLA-----------PLLHKLIALLPLAEQ--- 1829
            ..|.| |||                 .|.....|||           |.|.:|.|::..||:
Human   166 QQLVR-CLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCAEEEPP 229

  Fly  1830 ---MSSGNQHTQFLLSE------EGKDPYGPACRDYFWLLARLVDTLSPEM-------------- 1871
               ::|..||....|.:      ...|....:  .....::|::|.:|..:
Human   230 SSALASVVQHLPLELMDGVVRNLSNDDSVTDS--QMLTAISRMIDWVSWPLGKNIDKWIIALLKG 292

  Fly  1872 ---VAEEHIDIEMLCESISQ---------------SILTREYYELRHGYQDDGLV--GLLNLMSN 1916
               |.:..|.||:....|.:               |:|.......:|.::...|:  .:..::::
Human   293 LAAVKKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVAS 357

  Fly  1917 LIKYDTTFKYTPKALSFIEQLIG----FLFDMPSPADRQKPKCKSASSRASAYDLLVELCRGCAT 1977
            |:|.|:.     ...|.:|||..    .:|..|...|..:|..::...
Human   358 LVKEDSN-----SGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKD----------------- 400

  Fly  1978 NYAYLH-------GRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYM 2035
                ||       .:||.|.....::.....::||...:::.|.:||.|||.|||:.|.:|.|:|
Human   401 ----LHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFM 461

  Fly  2036 MPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQP-LNTGEQKD 2099
            ....|..|||:..|.::   |.:.:||.:|.:|..|:|.:.:|.:|   ......| .:.|.|:|
Human   462 ASDFRHCVLRLTENNSQ---PLMTKLQWLFGFLEHSQRPAISPENF---LSASWTPWFSPGTQQD 520

  Fly  2100 MAEFFIDLVSKLED-------MTPDLKH----------------LVKRLFCGSLSNNVVSLDCGH 2141
            .:|:...|:.:|.:       :...||.                .|:::|.|.:...:..|.|.:
Human   521 CSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLN 585

  Fly  2142 VSRTAEDFYTV--------RCQVADMRNLQESLDEVTVK-------------------------- 2172
            ||...|.|..:        ||:...:.::....:::|.:
Human   586 VSSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQRKHCITE 650

  Fly  2173 DT------LEG------------------------------------------------------ 2177
            ||      :||
Human   651 DTPPTSLYIEGLDSKEAGGQSSQEERIEREEEGKEERTEKEEVGEEEESTRGEGEREKEEEVEEE 715

  Fly  2178 -------------------------------------------------------------DNMY 2181
                                                                         :|.|
Human   716 EEKVEKETEKEAEQEKEEDSLGAGTHPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRY 780

  Fly  2182 TCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMP 2246
            .|..|.....|||.....:.|..|....:|::|::.||.:.|:....|.||.|.         :|
Human   781 YCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLR---------LP 836

  Fly  2247 QQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG-TADGGHYYSFI 2310
            .               |.|.|..                   |:|..|.||:| :::.||||.:.
Human   837 L---------------AGGRGQA-------------------YDLCSVVVHSGVSSESGHYYCYA 867

  Fly  2311 KE---RTKTSYHTHER------WFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSF 2366
            :|   |...|..|.:|      |:||||..|                 :..:::||:..   .||
Human   868 REGAARPAASLGTADRPEPENQWYLFNDTRV-----------------SFSSFESVSNV---TSF 912

  Fly  2367 EKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSE--AEEPTKMETSSSEIKADVDVEV 2429
            ...::||:|||.:|               |...|..|..|.  ..|||..:.....|..|..:.:
Human   913 FPKDTAYVLFYRQR---------------PREGPEAELGSSRVRTEPTLHKDLMEAISKDNILYL 962

  Fly  2430 EVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDE 2464
            :.:||:....|...:....:|......|:...:||
Human   963 QEQEKEARSRAAYISALPTSPHWGRGFDEDKDEDE 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	105/557 (19%)
		UCH	2014..2377	CDD:278850	101/551 (18%)
		DUF3517	2723..>2877	CDD:288853
USP35	NP_065849.1	UCH	441..923	CDD:278850	101/550 (18%)
		Peptidase_C19	442..924	CDD:271592	102/550 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	544..566		2/21 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..757		5/146 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	984..1011		3/14 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910