DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and usp38

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_003197722.1	Gene:	usp38 / 563778	ZFINID:	ZDB-GENE-101007-2	Length:	1014	Species:	Danio rerio

Alignment Length:	1082	Identity:	212/1082 - (19%)
Similarity:	366/1082 - (33%)	Gaps:	383/1082 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1637 FSEGQLQQ---SAHPKELALNEWRHDCLASLLRILWLLGFEE-LQSADAHVLMSRPHPFMLQLME 1697
            |..|.|||   |...::.|:.::.|..|..|:....:|.... ||:....::..||.|
Zfish    84 FVLGLLQQGYGSLDHRDPAILDFIHSSLRLLISCPAVLELAPLLQTEVLRIICERPEP------- 141

  Fly  1698 VPQCLTRLSSILNDEVHQQHQASSANPLVFPYQFQHLRTGFWGRAQLIQ-FAMNILVSFVHASA- 1760
             ..| .:|::||.|               |.......:.|.....||:: ||      :.|..|
Zfish   142 -ATC-AKLATILTD---------------FSQCIPRDKAGVLFCQQLVRTFA------YFHCPAS 183

  Fly  1761 EARRLLWAPTGTDHCRWLQKFILEDPEPAVRREICAGLYRICLGNAHSYRLLLAPLLHKLIALLP 1825
            |.|.|....|.......|.:.|.: .||.........::.|......|:...:|  |..|:..:|
Zfish   184 EERELREYVTQVSRVSALLQVIWK-AEPTTLLPSLQEVFSIISSTDPSFEPSIA--LASLVQHIP 245

  Fly  1826 L-----------AEQMSSGNQHTQFLLSEEGKDPYGPACRDYFWL---LARLVDT----LSPEMV 1872
            |           .:|.......||.|            ||...||   ||..|||    |...:.
Zfish   246 LQMITVLIKSLTTDQNVKDASMTQAL------------CRMIDWLSWPLANHVDTWVIALLKGLA 298

  Fly  1873 AEEH----IDIEMLCESISQSILTREYYELRHGYQDDGLVGLLNLMSNLIKYDTTFKYTPKALSF 1933
            |.:.    ||:.:|  .|.| :..|.:|.:..       .|.|.::|:::   .:|:::|:|...
Zfish   299 AVQKFTILIDVTLL--KIEQ-VFNRLWYPIVR-------QGALVVLSHML---LSFQHSPEAFHL 350

  Fly  1934 IEQLIGFLFDMPSPADRQKPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPY 1998
            :...|     :|.....:.....::.:....:..|:.......:.:..|:..:|...|..||
Zfish   351 VVPHI-----VPLVKSLKNDGLPNSKTFLLQFAELIHCMMYQYSGFPDLYDSILESIKELPK--- 407

  Fly  1999 PWDYWPRDE--------------------------GRAECGYVGLTNLGATCYMASCVQHLYMMP 2037
                 |.:|                          |::|.|..||.|||.||||.|.:|.|:|..
Zfish   408 -----PSEEKIKFVLNQSAWTSQSNSFASGLLKITGKSETGKTGLVNLGNTCYMNSILQILFMAT 467

  Fly  2038 QARAAVLRVPPNAARKHGPTLL-ELQRMFAYLLESERKSYNPRSFCRVYQMDHQP--LNTGEQKD 2099
            ..|..|:.:..|.:.    ||: :||.:||:|..::|.:|:||||..|    .:|  .:.|.|:|
Zfish   468 DFRRHVMSLQLNGSN----TLMKKLQLLFAFLAHTQRAAYSPRSFLDV----SRPTWFSAGSQQD 524

  Fly  2100 MAEFFIDLVSKLED-------------------MTPDLKH------------------------- 2120
            .:|:...|:.:|.:                   .:|:..|
Zfish   525 CSEYLRFLLDRLHEEEKALSALQTASPKPEPATTSPETLHNAVSPPISDVPSHPDPAAAQGETGT 589

  Fly  2121 LVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVR-------------------------CQ----- 2155
            ||:|:|.|.||..:..|.|..:|...|.|..:.                         ||
Zfish   590 LVERMFGGRLSTAIRCLQCHSLSEKEEPFTDLSLAFCPSMSQPRGPTNEHKSSSTLGPCQGAVNG 654

  Fly  2156 ---------------------VADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFK 2199
                                 |....::.:.:|.....:.||.:|.|.|.:|....||||.....
Zfish   655 GSEASEGPVKEGAASGMERPMVEPTISVPDLVDYFLAPEILENENCYFCERCASLQRAEKAMRVV 719

  Fly  2200 KLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNM------------------------CHYV 2240
            ..|:.|....:|::::....::.|:..:...||.:::                        |..:
Zfish   720 AAPEYLILTLLRFSYDATCHVRRKILDNVGIPLHMSLPLHQHSSSSSSNVAASSSTESPDSCENL 784

  Fly  2241 EKTLMPQQYKEE--RERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG-TAD 2302
            .|.|.|.| |||  .|.|.|.|:      :.:|.:|...          .|.|..|.:|:| ::|
Zfish   785 AKKLKPSQ-KEEGIAESRMKSKK------NNSDLQKLSV----------PYVLSSVVMHSGMSSD 832

  Fly  2303 GGHYYSFIK--------------------ERTKTSYHTHER----------WFLFNDAEVKPFDP 2337
            .|||||:.:                    .::::|....|.          ||||||:.|
Zfish   833 SGHYYSYGRNVSSDDGCVAHTSPKSLDNSSQSESSTAPQEETGRADPKSADWFLFNDSRV----- 892

  Fly  2338 SQIAAECFGGEMTS-KTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPT 2401
                      ..|: ::..:||.::      ..::||:|.|.::
Zfish   893 ----------TFTNFQSLQNVTSRF------PKDTAYVLIYRKQ--------------------- 920

  Fly  2402 VEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDE-- 2464
                                      ||..|..:..........|.|.|.::|:.|..:|.::
Zfish   921 --------------------------EVSGEASNSGPVVNGARLSGEPPLQKELMDAITKDNKLF 959

  Fly  2465 PEEKKIEKQSREGEEKSET-DEKPTEMTTVSTEEEKQPTANC 2505
            .:|:::..::|..:..|.: ..:|      :..::.:|..:|
Zfish   960 LQEQELNARTRALQATSASCSFRP------NGSDDNEPPGSC 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	113/524 (22%)
		UCH	2014..2377	CDD:278850	111/518 (21%)
		DUF3517	2723..>2877	CDD:288853
usp38	XP_003197722.1	UCH	445..917	CDD:278850	111/517 (21%)
usp38	XP_003197722.1	Peptidase_C19H	446..918	CDD:239129	111/517 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910