DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and usp7

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_009297739.2	Gene:	usp7 / 553758	ZFINID:	ZDB-GENE-030131-3656	Length:	1130	Species:	Danio rerio

Alignment Length:	1044	Identity:	216/1044 - (20%)
Similarity:	362/1044 - (34%)	Gaps:	299/1044 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2000 WDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRM 2064
            ||      .:...|||||.|.||||||.|.:|.|:...|.|.||..:|...........|.|||:
Zfish   226 WD------SKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRRAVYMMPTEGDDSSKSVPLALQRV 284

  Fly  2065 FAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPD--LKHLVKRLFC 2127
            | |.|:...|....:...:.:  ..:.|::..|.|:.|....|:..:|:....  ::..:.:||.
Zfish   285 F-YELQHSDKPVGTKKLTKSF--GWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFR 346

  Fly  2128 GSLSNNVVSLDCGHV---SRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKK 2189
            |.:   |..:.|.||   |...||:|.::..:...:|:.||..:....:.|:|||.|...:.|.:
Zfish   347 GKM---VSYIQCKHVDYRSERIEDYYDIQLSIKGKKNIFESFKDYVAVEQLDGDNKYDAGEHGLQ 408

  Fly  2190 VRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERE 2254
             .|||...|...|.||....||:.::..|....|:|..|.||.:|.:..:::|
Zfish   409 -EAEKGVKFLTFPPILHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQK------------ 460

  Fly  2255 RRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFI--KERTKTS 2317
                                      .|:::...|.|..|.||:|...||||..::  |...|.|
Zfish   461 --------------------------PDVKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKVS 499

  Fly  2318 YHTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFY--ERR 2380
            . |...|..|:|         .:.:.|...|.|...|....:   |.|.....:||||.|  |.:
Zfish   500 V-TAPIWCKFDD---------DVVSRCTKEEATEHNYGGHDD---DLSVRHCTNAYMLVYIRESK 551

  Fly  2381 LPEHLQRRHSELLVTPTPSP-----TVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEK------ 2434
            |.|.||.      ||....|     .::|:...|...:.|...:.:.  :.|::..|::
Zfish   552 LSEVLQP------VTDMDIPQQLVERLQEEKRVEAQKRKERQEAHLY--MQVQMVTEDQFCGHQG 608

  Fly  2435 ----DKEKPAQTDTESKETPAKEEIADDKSK-----QDEPEEKKIEKQSREGEEKSETDEKPTEM 2490
                |:||...|..:..::....|...:.|:     ||:.....::.:|...:..:..|.:
Zfish   609 NDMYDEEKVKYTVFKVLKSSTLAEFVQNLSQTMGFPQDQMRLWPMQARSNGTKRPAMLDYE---- 669

  Fly  2491 TTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPST--------SKAAQKLQLFRPLLNKELEDW 2547
                        |:|      |.|....|:::.|.|        ..||....|  |..:|:
Zfish   670 ------------ADC------NKSMIDLSDNENPWTIFLETVDPEMAASGATL--PKFDKD---- 710

  Fly  2548 IWQDNRQFLQDRNIFEHTY------FNFMWQICGHIPQSLISETDVTC--------MAAKLSVSF 2598
                     .|..:|...|      .|:    ||||      .|.::|        |..:.....
Zfish   711 ---------HDVMLFLKMYDPKTRSLNY----CGHI------YTPISCKIRDLLPVMCERAGFQQ 756

  Fly  2599 FIETFIHAKEKPTMVPWV------------ELLTKQFNASQE------------ACEWFLSHMSQ 2639
            .....::.:.||.:...:            ||:.......|:            |.::|     :
Zfish   757 GTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDTSELPTAKDYF-----R 816

  Fly  2640 EPYWPVQVLIQC-------PNQMV----RQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIG 2693
            :.|..|.|:. |       |..:|    |..:.::...|.|:|...  .:.|:....:..::..|
Zfish   817 DLYHRVDVIF-CDKTIHNDPGFVVTLSNRMNYFQVAKTVAQRLNTD--PMLLQFFKSQGYRDGPG 878

  Fly  2694 QASCVTRFIGSLISLLEHGARANLRHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHK 2758
            ..             |.|.....||.|.::|       :....:.:|..:   ||..:..:...:
Zfish   879 NP-------------LRHNYEGTLRDLLQFF-------KPRQPKKLYYQQ---LKMKITDFENRR 920

  Fly  2759 QTDSIDISSDNEDNSSEEALSVEKMRPASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGK 2823
            ...:|.::|    ...||.:::...:...:..::..|...||.|.....:|||
Zfish   921 SFKAIWLNS----MFREEEITLYPDKHGCVRDLLEECKKAVELSDKGSEKLRL------------ 969

  Fly  2824 GFPFLYQQIKDGINPHQTKHLIHALC-------RWDERLATQIIGMLFASVTKHTELCAPF---- 2877
             ...:..:|   |..||...|:..|.       |.:|....|:      .:.|..|:..|.
Zfish   970 -LEIVSYKI---IGVHQEDELLECLSPAASRTFRIEEIPLDQV------DLDKENEMLIPVAHFH 1024

  Fly  2878 ------FKLLTLLTETQGGPVGLPCFTQLILPRMWDAAEYCPQSVLDWLSLQATKNKIA------ 2930
                  |.:..||...||.|     |.: ::.|:        ||:||....:..|.|.|
Zfish  1025 KEVFGTFGIPFLLKIRQGEP-----FRE-VMKRI--------QSMLDIQEKEFEKFKFAIVMMGR 1075

  Fly  2931 HAWI 2934
            |.:|
Zfish  1076 HQYI 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	101/377 (27%)
		UCH	2014..2377	CDD:278850	98/369 (27%)
		DUF3517	2723..>2877	CDD:288853	26/160 (16%)
usp7	XP_009297739.2	Peptidase_C19	77..1128	CDD:321984	216/1044 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810