Protein Alignment puf and faf

DIOPT Version :9

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Alignment Length: 3637
• Identity: 652/3637 - (17%)
• Similarity: 1104/3637 - (30%)
• Gaps: 1421/3637 - (39%)

  Fly   105 REQQRDEASAQAEAKESSAPAEEPKKEEPSGSAGEEA------------------QGSGDGPAKK 151
            |.....:..:.|.:..||..:.......|:.|||..:                  .||.||...:
  Fly     6 RRHTTGQPGSTAPSSSSSTTSTTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGSLDGNQDQ 70

  Fly   152 PPV-------------------GPCTPPPPQ---TANPQHK--SHLQYTEEP-WILPEV--EKLL 189
            .|.                   ...|..||:   ::.|..|  |..|....| |::|.:  ::|.
  Fly    71 QPATDSQSSDDVAASLSANSVDSTITIVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELE 135

  Fly   190 VLVSKVFLLN--------FPLYIAHKHGMHSRLDDLQAEEA--------HHLALI-CD--LH--- 232
            ||::....|.        .|....:::|:.:....:..:||        ||..|: |.  ||
  Fly   136 VLLNAAIELTQAGVDHDCEPCVEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIA 200

  Fly   233 ---DNDLPIYLLRNVSLF------CNSGGFGAMSLCFEHPD------------------------ 264
               ..|.| |||..:::.      .|:...|....||..||
  Fly   201 IHMQRDNP-YLLDLLAIVFDPENKFNTFNAGRQPECFAAPDYIWGQLDSNKMYARPPPEPKNARG 264

  Fly   265 -------------------------------------------------------LPVSTAHSMT 274
                                                                   |.::..||:.
  Fly   265 WLVDLINRFGQLGGFDNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLL 329

  Fly   275 AAVSNVKLWLNYHCNTQLFVPLRSRILQYMCKLSDQSL-RSAATRAMADFVWSSMRDPLDVAVNF 338
            .........|......:.|:|..:.:|..:...:|:.| |........|::...::....:|...
  Fly   330 RPFGQCYELLMPATIAKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRL 394

  Fly   339 -DTEGLALAFKYFTSTTLTMRLAGMAQINAHINLFNEI-------------------CTTETVNE 383
             ..|.|....:.| ...:.:||..::..|..:|..|||                   |..|  :|
  Fly   395 TGQEELIRDLEMF-RLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPE--DE 456

  Fly   384 VE-LFGQRIANWLTENHIVQHLFGPNLH-VEIVKQAHVLLNFLAVENQISEEDIKLIWQATQLKH 446
            :: |...|:|.|:..:.::..:...:|| .:.|::...::.||..|..::.:|:..:|:|...||
  Fly   457 MDWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKH 521

  Fly   447 --CSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTEQSIYIASALTKQLWTRDTSRSQMNL 509
              ..|.:.|:|..|..:.||....||:...
  Fly   522 EAIVKNVHDLLAKLAWDFTPEQLDHLFEAF----------------------------------- 551

  Fly   510 MQDHLLGSNVTASSSDSGSIEGSNTEDDHVGADDSSIASGGGGGGVGNKSPIDGVTPCKQARHRR 574
                                                                             
  Fly   552 ----------------------------------------------------------------- 551

  Fly   575 HICDPTTEKGKQISPEDMAKVDLVNKRIVNIIDNTSSEEELQSRAALELQLHRSRKKTSNKRRRQ 639
                             .|.:...|||              |....|||           .||..
  Fly   552 -----------------QASMTTANKR--------------QRERLLEL-----------IRRLA 574

  Fly   640 KTNKQIILPHELVEI-WDGVEDVPSSDEADGEADGDGEGELLADSDECSDGATSQLVPDAVLKHL 703
            :.:|..::..::::: |                       .||.|.|         ||..||.
  Fly   575 EDDKNGVMAQKVLKLFW-----------------------TLAHSQE---------VPPEVLD-- 605

  Fly   704 QGEGPFIRAIETNINELLSGAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQLVSSRANCS 768
            |..|..::.::               ||......::|.:.      :..|.:||
  Fly   606 QALGAHVKILD---------------YSCSQERDAQKTIW------LDKCVDEL----------- 638

  Fly   769 DVPPAFAAAAAAMMVAQSAMALQKSGESNVAAAAAAVAAAA----AATGTAQQTLVAMNRQASVA 829
                                   |||:..|..|...:....    ..|..||:|..:.|||..:
  Fly   639 -----------------------KSGDGWVLPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVI- 679

  Fly   830 AAAAVVAAAKAKSDSDVDLMDVVSGGKQHHSPKASQGSSTS-----------GSTP--VQPSFKL 881
                      .:..:|..|:.:|:.....:..|..|..:.|           |..|  ||.:.:|
  Fly   680 ----------ERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQIAERL 734

  Fly   882 NDVCQPGNTLLWDLLQD-------DKIGQLGESLALEAEKALATLLCFSMDRQLRTKFIEGCLYN 939
            .        .|..||:|       |:..|:...||:.|        .|..||       |.|
  Fly   735 E--------FLKFLLKDGQLWLCADQAKQIWHCLAVNA--------VFPADR-------EEC--- 773

  Fly   940 VANNRSVIVSLRLLPKLFASFQQFRPSDTHSMTMWAERNHRMMQCFFNNIRHYARRHAEVLITQN 1004
                      .|...||........|.              :.:.||.|.......|   |:|::
  Fly   774 ----------FRWFGKLMGEEPDLDPG--------------INKDFFENNILQLDPH---LLTES 811

  Fly  1005 GEQQQQQLGGQLYSHKTQVSVRLQFLSSIFSTVGSP--------KSFRLTLEQL---DALWEWLA 1058
            |                     ::.....|..|.|.        :.:.|..|.|   |.||..:
  Fly   812 G---------------------IKCFERFFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVI- 854

  Fly  1059 HDPECADCYFSWLQAQAKGGDQHA-LGIEALQHLYLKKLPELRPE--EFSMVALGLFQQLCSFAR 1120
                            ..||::.| ..|:.|:.:.....|.|:..  ||..:.:|   :.||..|
  Fly   855 ----------------TTGGEEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIG---ECCSRLR 900

  Fly  1121 IAMAEYDNHSDQISASASAVGMYHLWKIALRAQ---------SNDVSL-AAIQYINMYYMGQQLR 1175
               ..|.|             :..|.|..|:.:         :||.|. :.:::|....|.:.|:
  Fly   901 ---THYGN-------------IVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILK 949

  Fly  1176 LEKEFVSQCMENLVQAATALESIDDENALMRVQRGLLLLNTHLDTFRRRYAFHLRRWAIEGKGIG 1240
            :.:|:|.:|..:.......|       .|.||.||   .||.|     ...|.....:|:...|.
  Fly   950 VLQEYVKECDRSFSGDRVHL-------PLSRVTRG---KNTIL-----YIRFQNPGRSIDDMEIV 999

  Fly  1241 SHSNLKNEGAGPPLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESLQTGLAAPVLGLLLS 1305
            :|||              :.....:::||:.......|::|.::                 ...:
  Fly  1000 THSN--------------ETMAAFKRNLLKRIKGTSTANIKVDL-----------------FYAN 1033

  Fly  1306 DGPLRIITQGQELTSDYDERSLGDAGFKDNQIVYVSLGGRG-ARRKESNLEHPSMLPPPP----- 1364
            |   .:|....|:...| :.::.|   |.|....::..|.| |...:|:.:..:..||.|
  Fly  1034 D---EMIGVSDEINPLY-QYTIRD---KMNLTAKLTPVGTGLASSPDSSSDSSTGSPPRPCPDMQ 1091

  Fly  1365 ----KECLPTVLLLQPKYFEKLFCLMQTLGDMQPQASTVNPQHHTKAQLLSRRVWD----ILAML 1421
                :..||.|::.|...:.:.|..:..||                :.|...|:.|    :|.:|
  Fly  1092 RVESESTLPGVIISQNYQYTEFFLKLYQLG----------------SDLEHGRLRDSAKVLLHLL 1140

  Fly  1422 PTNPHILDAFKSLVTDLSELEQLDAGGEEEQLATKRKQIKQKFRDLLDPNNLQKFMYSLHIVESL 1486
            |.:                                    :|..|.|       |.|..   |...
  Fly  1141 PCD------------------------------------RQTIRQL-------KIMCK---VPKA 1159

  Fly  1487 ALTSSRRGESNGNVAMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMSKEQLCELEAPLTPTP 1551
            |:|.:..|:                                      |::|::    |..|.||.
  Fly  1160 AVTVAVTGD--------------------------------------KIAKDE----EEKLYPTE 1182

  Fly  1552 STGLQDVETEASSSSGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPPSPTPPPPALSVVERG 1616
            ..|::|                              |:|...|......|:|......|||:.
  Fly  1183 QAGIED------------------------------EEEHCTPEQMFLHPTPAQVLYNLSVLH-- 1215

  Fly  1617 DNKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKELALNEWRHD-CLASLLRILWLLGFEELQSAD 1680
                       |.|....:...|..|        |..:.|.|. |...:|.:|....|  |.|||
  Fly  1216 -----------GLLIPALDPLGESAL--------LVQSAWMHSGCAHFVLELLTKNNF--LPSAD 1259

  Fly  1681 AHVLMSRPHPFMLQLMEVPQCLTRLSSI-----------LNDE--VHQQHQASSANPLVFPYQFQ 1732
            .|   ::...|        ||:.||:.:           :.||  :......|.:...:....|.
  Fly  1260 MH---TKRASF--------QCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILKQNFS 1313

  Fly  1733 HLRTGFWGRAQLIQFAMNILVS--FVHASAEARR------------------------LLWA--- 1768
            .:.:...|..:.|...:.::::  .:.||.|..|                        |.||
  Fly  1314 TMPSSSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQWSCPDISTIKAVVQLAWASSC 1378

  Fly  1769 -------------------PTGTDH--CR-------------------------W---LQKFILE 1784
                               |.|.|.  |:                         |   :...:|:
  Fly  1379 GNLQALGNSSGDFEDEVIVPDGQDFSMCKEALEVLTISFILNPSANEALTSDPNWPKFITSIVLK 1443

  Fly  1785 DPEPAVRREICAGLY---RICLGNAHSYRLLLAPLLHKLIALLPLAEQMSSGNQHTQFLLSEEGK 1846
            :|...||:.....|:   ..|.|:...:..::..|:..|..|:|
  Fly  1444 NPLRHVRQVASEQLFLASTYCAGDRRPFVYMVNLLVGALKTLVP--------------------- 1487

  Fly  1847 DPYGPACRDYFWLLARLVD---------TLSPEMVAEEHIDIEMLCESISQSILTREYYELRHGY 1902
             .|...|.::|.:|.|.:.         .:|..::.:|...::.:.|::..:..|:.:.||..|:
  Fly  1488 -QYESTCAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVHATGDTQVHEELLEGH 1551

  Fly  1903 QDDGLVGLLNLMSNLIKY---DTTFKYTPKALSFIEQLI-GFLFDMPSPADRQ------------ 1951
                    |.|...|:.:   |:..:..    ..|.:|| .|||    .|.|:
  Fly  1552 --------LCLAKELMFFLGADSKAQLN----ELIHELIDDFLF----TASREFLHLRRHGSLRQ 1600

  Fly  1952 ----KPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAEC 2012
                .|.|:|..:.|:|.|||:.||:.|..|...|...|:....:.......|||.|....|...
  Fly  1601 DTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTK 1665

  Fly  2013 GYVGLTNLGATCYMASCVQHLYMMPQARAAVLRV-----------------------------PP 2048
            |:.||.|.||||||.|.:|.|||:|..|..:||.                             |.
  Fly  1666 GFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPA 1730

  Fly  2049 NA-----------------ARK--HGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNT 2094
            :|                 .||  |...|..:|.:||:|..|..:.|.||.....:::..:|:|.
  Fly  1731 SALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNL 1795

  Fly  2095 GEQKDMAEFFIDLVSKLEDMTPDL--KHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVA 2157
            .||:|..|||:.|:..|::....|  ..|:.....||.|:..:..:|.|.....|.|......:.
  Fly  1796 REQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIR 1860

  Fly  2158 DMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKE 2222
            :..:|.|||::....:.|||.:.|.|.:|.|||...||.|.||||.:|.....|:.::...:...
  Fly  1861 NHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAI 1925

  Fly  2223 KVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECY 2287
            |.|.:|.||..|:|..|....|             .:.||.......|.....|.|
  Fly  1926 KFNDYFEFPRILDMEPYTVSGL-------------AKLEGEVVEVGDNCQTNVETT--------- 1968

  Fly  2288 EYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEV---KPFDPSQIAAECFGGEM 2349
            :|||.|:.||:|.|.||||:|:|  .:|...:...:|:.|:|.||   |..:..::.|||||||.
  Fly  1969 KYELTGIVVHSGQASGGHYFSYI--LSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEY 2031

  Fly  2350 TSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTP---SPTVEEKSEAEEP 2411
            ..:|||:..::......::..:||||||.|              ...||   .|:||:.|.||..
  Fly  2032 MGETYDNNLKRMQYRRQKRWWNAYMLFYTR--------------CDQTPVQYEPSVEQLSLAESR 2082

  Fly  2412 TKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSRE 2476
            ..:                                                 .|..|.||:..|
  Fly  2083 NMV-------------------------------------------------LPLPKPIERSVR- 2097

  Fly  2477 GEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLN 2541
                                           ||
  Fly  2098 -------------------------------HQ-------------------------------- 2099

  Fly  2542 KELEDWIWQDNRQFLQDRNIFEHTYFNFMWQICGHIPQSLIS---------ETDVTCMAAKLSVS 2597
                      |.:||..|:||...:|||:.::   :..:|:|         ..:::.:..:|:..
  Fly  2100 ----------NIRFLHSRSIFSVEFFNFIKKL---VSCNLLSARSNKITPAAEELSLLGVQLASQ 2151

  Fly  2598 FFIETFIHAKEK---PTMVPWVELLTKQFNASQEACEWFLSHMSQEPYWPVQV---LIQCPNQMV 2656
            |...|....|:.   |.| .|.:.|:....:|....:||.:|....|  |.::   ::..|:..|
  Fly  2152 FLFHTGFRTKKSLRGPVM-EWYDALSHHIRSSALVRKWFANHALLSP--PSRLGEYILMAPSPDV 2213

  Fly  2657 RQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQ--ASCVTRFIGSLISLLEHGARANLRH 2719
            |.:|.:||:.        ..|..:      :|:.|.|.  |:...:.:.|::.||:..|....:|
  Fly  2214 RTVFVKLVVF--------FCHFAI------NDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKH 2264

  Fly  2720 LSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQTDSIDISSDNEDNSSEEALSVEKMR 2784
            |..||.|...:..:|..|...|||:.|....:...|               |:....|:..:...
  Fly  2265 LPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVAL---------------DDGPGPAIKYQYPE 2314

  Fly  2785 PASLDKMIA---LCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDGINPHQTKHLIH 2846
            .:.|.::::   .|:.:.|:.:.::                       |..:...||.:..::.|
  Fly  2315 FSKLHQVVSHLIRCSDVSEKCQSSN-----------------------QNARPLSNPFKDPNVAH 2356

  Fly  2847 ALCRWDE--RLATQIIGMLFASVTKHTELCAPFFKLLTLLTETQGGPVGLPCFTQLILPRMWDAA 2909
                 :|  .|:|:.:.:|| :.|.:         :..::.:|..|..||    :|:....|:..
  Fly  2357 -----EELTPLSTECMDLLF-NRTGY---------IKKVIEDTNVGDEGL----KLLQYCSWENP 2402

  Fly  2910 EYCPQSVLDWLSLQATKNKIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVALVPSQPFRAN 2974
            .:....:.:.|                    |...|...||   :|:....||..|:....:: :
  Fly  2403 HFSRAVLTELL--------------------WQCGFAYCHD---MRHHTDLLLNILLIDDSWQ-H 2443

  Fly  2975 FRAHSQHKLLALNP---------HSYRDINSDAQAVLHQVITLLLRLLRPARVYADIGAHGTTKL 3030
            .|.|:     |||.         .:.:...:..|...:|:|..|.:|...:.:...: .|..:.:
  Fly  2444 HRIHN-----ALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQM-LHTNSNI 2502

  Fly  3031 TAYFNLLSYCMVSKTEKL--MASSYMRSLWELFHPRLSEPSVPAHHN----------KHALLTFW 3083
            |.::::....:..:.::.  :...|....|          |.||..|          ..:....|
  Fly  2503 TRHWSIAVEWLQGELDRQRGIGCQYNSYSW----------SPPAQSNDNTNGYMLERSQSAKNTW 2557

  Fly  3084 HHSLVDCPENAAQVA---NCPEITRNIAFNYILADHDDAEIVTYNRSMLPAYYGLLRLCCEQSRA 3145
            ..:...||:..::..   |.|.:..|:       |.:.:|.|.....:|           |.|..
  Fly  2558 SMAFELCPDEVSEKTDENNEPNLETNM-------DENKSEPVAQPGGVL-----------EGSTG 2604

  Fly  3146 LTRQLSQHQ--------NLQWAFK---NITPHPTQY----------------AAAVDELFKLMAL 3183
            .|.||.:::        ...|..:   |..|..::.                :|....|......
  Fly  2605 GTEQLPENKTPTTSSPSTAAWPARGDSNAIPRLSRQLFGAYTSTGSGSTSGGSAPTSALTTTAGS 2669

  Fly  3184 FATRHPDASEQEKLDVTQFRRAVIVSYTSSLD-----ARVSWSTLISALKILVD--NEEDRT 3238
            .|....::|.||....|     .|...|:|||     |:.....:|  :|.||:  :|||.|
  Fly  2670 GANSETESSAQETTGET-----TINGLTNSLDQMEITAKKKCRRVI--IKKLVESKDEEDAT 2724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	126/421 (30%)
		UCH	2014..2377	CDD:278850	122/415 (29%)
		DUF3517	2723..>2877	CDD:288853	25/158 (16%)
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	126/435 (29%)
		UCH	1668..2059	CDD:278850	122/414 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14202
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010